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Tardbp Gene Detail
Summary
  • Symbol
    Tardbp
  • Name
    TAR DNA binding protein
  • Synonyms
    1190002A23Rik, Tdp43, TDP-43
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387629
    NCBI Gene: 230908
  • Gene Overview
    MyGene.info: TARDBP
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148612382-148626996 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387629
protein coding gene Chr4:148612382-148627019 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029129
protein coding gene Chr4:152352514-152373828 (-)
A/J MGP_AJ_G0029094
protein coding gene Chr4:146048046-146062550 (-)
AKR/J MGP_AKRJ_G0029042
protein coding gene Chr4:150022141-150041361 (-)
BALB/cJ MGP_BALBcJ_G0029110
protein coding gene Chr4:146549432-146563949 (-)
C3H/HeJ MGP_C3HHeJ_G0028831
protein coding gene Chr4:150583314-150599850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029559
protein coding gene Chr4:157878724-157897439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026805
protein coding gene Chr4:138465683-138480129 (-)
CAST/EiJ MGP_CASTEiJ_G0028244
protein coding gene Chr4:147790672-147807479 (-)
CBA/J MGP_CBAJ_G0028793
protein coding gene Chr4:162477094-162492120 (-)
DBA/2J MGP_DBA2J_G0028942
protein coding gene Chr4:146156387-146171271 (-)
FVB/NJ MGP_FVBNJ_G0028906
protein coding gene Chr4:145244728-145259902 (-)
LP/J MGP_LPJ_G0029032
protein coding gene Chr4:152307052-152324766 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028933
protein coding gene Chr4:165774465-165791626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029591
protein coding gene Chr4:150518185-150532934 (-)
PWK/PhJ MGP_PWKPhJ_G0027964
protein coding gene Chr4:142142947-142159235 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027798
protein coding gene Chr4:144762725-144777355 (-)
WSB/EiJ MGP_WSBEiJ_G0028324
protein coding gene Chr4:150677405-150692626 (-)



Homology
more
  • Human Ortholog
    TARDBP, TAR DNA binding protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TARDBP, TAR DNA binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALS10, TDP-43
  • Links
    NCBI Gene ID: 23435
    neXtProt AC: NX_Q13148
    UniProt: Q13148

  • Chr Location
    1p36.22; chr1:11012622-11030528 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Tardbp mouse models; 1 with human TARDBP associations

Human Disease Mouse Models
      
IDs
View 19 models
      
IDs
View 5 models
IDs
View 7 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    20 with disease annotations
  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 12 alleles in 12 genetic backgrounds
    117 phenotypes from multigenic genotypes
    1 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous deficient mice display embryonic lethality before somite formation with impaired inner cell mass proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230908 NCBI Gene Model | MGI Sequence Detail 14615 C57BL/6J ±  kb
    transcript NM_145556 RefSeq | MGI Sequence Detail 7454 C57BL/6  
    polypeptide Q921F2 UniProt | EBI | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 43
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1916123, MGI:2140695
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 11
      Diseases 16
      Gene Ontology 9
      Phenotypes 88
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:265666 Fratta P, et al., Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J. 2018 Jun 1;37(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory