About   Help   FAQ
Tardbp
Gene Detail
 Symbol
Name
ID
Tardbp
TAR DNA binding protein
MGI:2387629
Synonyms 1190002A23Rik, Tdp43, TDP-43
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148612382-148627019 bp, - strand
From VEGA annotation of GRCm38

  14638 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7221  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tardbp

Human
homologs
Human Homolog TARDBP, TAR DNA binding protein
NCBI Gene ID 23435
neXtProt AC  NX_Q13148
Human Synonyms  ALS10, TDP-43
Human Chr (Location)  1p36.22; chr1:11012622-11025492 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TARDBP
Mutations,
alleles, and
phenotypes
All mutations/alleles(148) : Chemically induced (ENU)(1) Gene trapped(139) Targeted(8)
Incidental mutations (data from APF )
 
Homozygous deficient mice display embryonic lethality before somite formation with impaired inner cell mass proliferation.
 
Human Diseases Modeled Using Mouse Tardbp (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Tardbp interacts with 497 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process 3'-UTR-mediated mRNA stabilization, mRNA processing, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (276)    Tissues (112)    Images (55)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 58
In situ reporter (knock in) 51
Northern blot 4
Western blot 123
RT-PCR 26
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(36) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000010947 (Evidence)
Ensembl Gene ModelENSMUSG00000041459 (Evidence)
Entrez Gene230908 (Evidence)
NIA Mouse Gene IndexU025792, U069876, U358201
PDB3D2W
Consensus CDS ProjectCCDS38967.1, CCDS38968.1, CCDS38969.1, CCDS38970.1, CCDS38971.1
International Mouse Knockout Project StatusTardbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010947 VEGA Gene Model | MGI Sequence Detail 14638 C57BL/6J ±  kb
transcript OTTMUST00000025673 VEGA | MGI Sequence Detail 7477 Not Applicable 
polypeptide OTTMUSP00000011770 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(154) RefSeq(19) UniProt(11)
Polymorphisms SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000016057 TAR DNA-binding protein 43
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:211620 Ricketts T, et al., A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. PLoS One. 2014;9(1):e85962
All references(82)
Disease annotation references (1)
Other
accession IDs
MGI:1916123, MGI:2140695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory