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Tardbp
Gene Detail
Symbol

Name
ID
Tardbp
TAR DNA binding protein
MGI:2387629
Synonyms
1190002A23Rik, Tdp43, TDP-43
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148612382-148627019 bp, - strand
From VEGA annotation of GRCm38

  14638 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7221  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TARDBP
Gene Tree: Tardbp

Human
homologs
TARDBP, TAR DNA binding protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23435
neXtProt AC: NX_Q13148

Human Synonyms: ALS10, TDP-43

Human Chr (Location): 1p36.22; chr1:11012622-11025492 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TARDBP

Mutations,
alleles, and
phenotypes
All mutations/alleles(169) : Chemically induced (ENU)(1) Gene trapped(139) Targeted(11) Transgenic(18)
Genomic Mutations involving Tardbp (1)
Incidental mutations (data from APF , CvDC )
 
Homozygous deficient mice display embryonic lethality before somite formation with impaired inner cell mass proliferation.
 
Human Diseases Modeled in Mice Using Tardbp (2)    Mutations Annotated to Human Diseases (15)   
Interactions
Tardbp interacts with 497 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process 3'-UTR-mediated mRNA stabilization, mRNA processing, ...
Component nucleoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (276)    Tissues (112)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 58
In situ reporter (knock in) 51
Northern blot 4
Western blot 123
RT-PCR 26
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TARDBP ; Xenbase tardbp ; ZFIN tardbp    NEW 
Molecular
reagents
All nucleic(45) cDNA(41) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000010947 (Evidence)
Ensembl Gene Model ENSMUSG00000041459 (Evidence)
Entrez Gene 230908 (Evidence)
NIA Mouse Gene Index U025792, U069876, U358201
PDB 3D2W
Consensus CDS Project CCDS38967.1, CCDS38968.1, CCDS38969.1, CCDS38970.1, CCDS38971.1
International Mouse Phenotyping Consortium Status Tardbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010947 VEGA Gene Model | MGI Sequence Detail 14638 C57BL/6J ±  kb
transcript OTTMUST00000025673 VEGA | MGI Sequence Detail 7477 Not Applicable 
polypeptide OTTMUSP00000011770 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(213) RefSeq(22) UniProt(25)
Polymorphisms
SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000016057 TAR DNA-binding protein 43
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:215201 Dib S, et al., Gene targeting of mouse Tardbp negatively affects Masp2 expression. PLoS One. 2014;9(4):e95373
All references(84)
Disease annotation references (2)
Other
accession IDs
MGI:1916123, MGI:2140695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory