Tardbp
Gene Detail

Symbol Name ID

Tardbp TAR DNA binding protein MGI:2387629

Synonyms

1190002A23Rik, Tdp43, TDP-43

Feature Type

protein coding gene

Genetic Map

Chromosome 4

78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:148612382-148627019 bp, - strand From VEGA annotation of GRCm38   14638 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Tardbp ± 2 cM)

Gene Tree: Tardbp

Human ortholog

TARDBP TAR DNA binding protein NCBI Gene ID 23435
Human Synonyms: ALS10, TDP-43
Human Chr1:11072679-11085549 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human TARDBP (1)

Alleles and phenotypes

All alleles(146) : Targeted(7) Gene trapped(139)
 

Homozygous deficient mice display embryonic lethality before somite formation with impaired inner cell mass proliferation.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	3'-UTR-mediated mRNA stabilization, mRNA processing, ...
Component	nucleus
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (276)    Tissues (107)    Images (54)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	58
In situ reporter (knock in)	51
Northern blot	4
Western blot	123
RT-PCR	26

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(36) Primer pair(4)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000010947 (Evidence)
Ensembl Gene Model	ENSMUSG00000041459 (Evidence)
Entrez Gene	230908 (Evidence)
NIA Mouse Gene Index	U025792, U069876, U358201
PDB	3D2W
Consensus CDS Project	CCDS38967.1, CCDS38968.1, CCDS38969.1, CCDS38970.1, CCDS38971.1
International Mouse Knockout Project Status	Tardbp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010947	VEGA Gene Model | MGI Sequence Detail	14638	C57BL/6J
transcript	OTTMUST00000025673	VEGA | MGI Sequence Detail	7477	Not Applicable
polypeptide	OTTMUSP00000011770	VEGA | MGI Sequence Detail	414	Not Applicable

All sequences(108) RefSeq(11) UniProt(11)

Polymorphisms

SNPs(152 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000016057	TAR DNA-binding protein 43

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:192743 Scofield MD, et al., Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience. 2012 Dec 27;227:44-54
All references(73)

Other accession IDs

MGI:1916123, MGI:2140695