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Tardbp Gene Detail
Summary
  • Symbol
    Tardbp
  • Name
    TAR DNA binding protein
  • Synonyms
    1190002A23Rik, Tdp43, TDP-43
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387629
    NCBI Gene: 230908
  • Gene Overview
    MyGene.info: TARDBP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:148612382-148627019 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14638 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.77 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TARDBP, TAR DNA binding protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TARDBP, TAR DNA binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS10, TDP-43
  • Links
    NCBI Gene ID: 23435
    neXtProt AC: NX_Q13148
    UniProt: Q13148

  • Chr Location
    1p36.22; chr1:11012622-11030528 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Tardbp mouse models; 1 with human TARDBP associations

Human Disease Mouse Models
      
IDs
View 19 models
      
IDs
View 5 models
IDs
View 7 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    20 with disease annotations
  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 12 alleles in 12 genetic backgrounds
    117 phenotypes from multigenic genotypes
    1 images
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous deficient mice display embryonic lethality before somite formation with impaired inner cell mass proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010947 VEGA Gene Model | MGI Sequence Detail 14638 C57BL/6J ±  kb
    transcript OTTMUST00000025673 VEGA | MGI Sequence Detail 7477 Not Applicable  
    polypeptide OTTMUSP00000011770 VEGA | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      149 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 43
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1916123, MGI:2140695
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 10
      Diseases 16
      Gene Ontology 7
      Phenotypes 84
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:264748 van Hummel A, et al., Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice. Am J Pathol. 2018 Jun;188(6):1447-1456

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory