|
Symbol Name ID |
Tardbp
TAR DNA binding protein MGI:2387629 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Depression |
Emotional lability |
Atypical behavior |
Apathy |
Reduced social reciprocity |
Disinhibition |
Impulsivity |
Agitation |
Restless legs |
Motor stereotypy |
Fatigue |
Pain |
| Disease(s) Associated with TARDBP | ||||||||||||
| amyotrophic lateral sclerosis | ||||||||||||
| amyotrophic lateral sclerosis type 10 | ||||||||||||
| Parkinson's disease |
| Mouse Phenotypes | behavior/neurological phenotype |
abnormal cognition |
abnormal learning/memory/conditioning |
impaired contextual conditioning behavior |
abnormal object recognition memory |
impaired short-term object recognition memory |
abnormal spatial learning |
impaired spatial learning |
cognitive inflexibility |
abnormal eating behavior |
abnormal food intake |
polyphagia |
increased anxiety-related response |
abnormal motor capabilities/coordination/movement |
abnormal startle reflex |
limb grasping |
tremors |
impaired coordination |
impaired limb coordination |
decreased grip strength |
head bobbing |
abnormal locomotor behavior |
abnormal gait |
short stride length |
decreased vertical activity |
increased vertical activity |
decreased locomotor activity |
hyperactivity |
paralysis |
hindlimb paralysis |
spasticity |
decreased stereotypic behavior |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
| Tardbpem1Koya/Tardbpem1Koya | * | ||||||||||||||||||||||||||||||||
| Tardbpem1Rhbr/Tardbpem1Rhbr | * | ||||||||||||||||||||||||||||||||
| TardbpRgsc2223/TardbpRgsc2223 | |||||||||||||||||||||||||||||||||
| Tardbptm2.1Ckjs/Tardbptm2.1Ckjs | * | ||||||||||||||||||||||||||||||||
| Tg(Camk2a-Tardbp)#Ckjs/Tg(Camk2a-Tardbp)#Ckjs | |||||||||||||||||||||||||||||||||
| Tardbpem1Rhbr/Tardbp+ | |||||||||||||||||||||||||||||||||
| TardbpGt(RRB030)Byg/Tardbp+ | |||||||||||||||||||||||||||||||||
| Tardbpm1H/Tardbp+ | |||||||||||||||||||||||||||||||||
| Tardbptm1.1Hiok/Tardbp+ | |||||||||||||||||||||||||||||||||
| Tardbptm1b(EUCOMM)Wtsi/Tardbp+ | |||||||||||||||||||||||||||||||||
| Tardbptm3.1Ckjs/Tardbp+ | |||||||||||||||||||||||||||||||||
| Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu/0 | |||||||||||||||||||||||||||||||||
| Tg(CAG-EGFP,-dsRed2/RNAi:Tardbp)6Zxu/0 | * | ||||||||||||||||||||||||||||||||
| Tg(Camk2a-Tardbp)#Ckjs/0 | |||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ Tardbptm1.1Pcw/Tardbptm1.1Pcw (conditional) |
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| Tardbptm1.1Sobue/Tardbptm1.1Sobue Tg(SLC18A3-cre)Misa/0 (conditional) |
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| Mnx1tm4(cre)Tmj/Mnx1+ Tardbptm1.1Ckjs/Tardbptm1.2Cjks (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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