amyotrophic lateral sclerosis type 10 Disease Ontology Browser

Disease Ontology Browser

amyotrophic lateral sclerosis type 10 (DOID:0060201)
Alliance: disease page
Synonyms: ALS10; amyotrophic lateral sclerosis 10; amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; TARDBP-related frontotemporal lobar degeneration with TDP43 inclusions
Alt IDs: OMIM:612069
Definition: An amyotrophic lateral sclerosis that has_material_basis_in mutation in the TARDBP gene on chromosome 1.

Term Browser
Genes (2)
Models (24)

Disease References using Mouse Models (28)

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Gene: Tardbp

Allelic Composition	Genetic Background	Reference	Phenotypes
Tardbpem1Rhbr/Tardbpem1Rhbr	C57BL/6J-Tardbp^em1Rhbr	J:261673	View
Tardbptm1.1Neas/Tardbptm1.1Neas	B6(C3)-Tardbp^tm1.1Neas	J:283769	View
Tardbptm2.1Neas/Tardbptm2.1Neas	B6(C3)-Tardbp^tm2.1Neas	J:283769	View
Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu/0	involves: C57BL/6 * C57BL/6J * FVB/NJ * SJL	J:207750	View
Tardbptm3.1Ckjs/Tardbp+	involves: C57BL/6J	J:285792	View
Tardbptm1.1Sobue/Tardbptm1.1Sobue Tg(SLC18A3-cre)Misa/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NTac	J:324570	View
Mnx1tm4(cre)Tmj/Mnx1+ Tardbptm1.1Ckjs/Tardbptm1.2Cjks	involves: 129S1/Sv * C57BL/6J	J:190254	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu/0	involves: C57BL/6 * C57BL/6J * FVB/NJ * SJL	J:207750	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Prnp-TARDBP)3cPtrc

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc	C57BL/6-Tg(Prnp-TARDBP)3cPtrc	J:163231	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Prnp-TARDBP)4Jlel

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-TARDBP)4Jlel/0	involves: C57BL/6 * CD-1 * SJL	J:165985	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Prnp-TARDBP*A315T)23Jlel

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-TARDBP*A315T)23Jlel/0	involves: C57BL/6 * CD-1 * SJL	J:165985	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Prnp-TARDBP*A315T)95Balo

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-TARDBP*A315T)95Balo/0	involves: C57BL/6 * CBA	J:153197	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Prnp-TARDBP*Q331K)103Dwc

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-TARDBP*Q331K)103Dwc/0	B6.Cg-Tg(Prnp-TARDBP*Q331K)103Dwc/J	J:242322	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(TARDBP)#Jpj

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(TARDBP)#Jpj/0	involves: C3H * C57BL/6	J:195184	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(TARDBP*A315T)#Jpj

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(TARDBP*A315T)#Jpj/0	involves: C3H * C57BL/6	J:195184	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(TARDBP*G348C)#Jpj

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(TARDBP*G348C)#Jpj/0	involves: C3H * C57BL/6	J:195184	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(tetO-TARDBP)12Vle

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-TARDBP)12Vle/0	involves: C3H/HeJ * C57BL/6J	J:170756	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(tetO-TARDBP*)4Vle

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-TARDBP*)4Vle/0	involves: C3H/HeJ * C57BL/6J	J:170756	View
Tg(NEFH-tTA)8Vle/0 Tg(tetO-TARDBP*)4Vle/0	involves: C3H/HeJ * C57BL/6J	J:225639	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(tetO-TARDBP*A315T)13Lmit

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(tetO-TARDBP*A315T)13Lmit/0 Tg(Thy1-tTA)6Lmit/0	involves: C57BL/6	J:245760, J:242322	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Thy1-TARDBP)4Singh

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh	involves: C57BL/6J * SJL/J	J:157550	View
Tg(Thy1-TARDBP)4Singh/0	involves: C57BL/6J * SJL/J	J:157550	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Thy1-TARDBP)6Singh

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh	involves: C57BL/6 * C57BL/6J * SJL	J:157550	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10
Associated Mouse Transgene: Tg(Thy1-TARDBP*)BOddo

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Thy1-TARDBP)BOddo/Tg(Thy1-TARDBP)BOddo	C57BL/6-Tg(Thy1-TARDBP*)BOddo	J:223932	View

Mouse Models

Human Disease Modeled: amyotrophic lateral sclerosis type 10

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Prnp-TARDBP)96Dwc/0 Tg(Prnp-TARDBP*Q331K)31Dwc/0	involves: C3H * C57BL/6	J:239141	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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