Tg(Prnp-TARDBP)3cPtrc
Transgene Detail

Summary

• Symbol: Tg(Prnp-TARDBP)3cPtrc
• Name: transgene insertion 3c, Leonard Petrucelli
• MGI ID: MGI:5002476
• Synonyms: TDP-43^PrP, Tg(Prnp-TARDBP)3cLtrc
• Transgene: Tg(Prnp-TARDBP)3cPtrc Location: unknown
• Alliance: Tg(Prnp-TARDBP)3cPtrc page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-TARDBP)3cPtrc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The TDP-43PrP transgene was designed with the human TAR DNA binding protein (TARDBP or TDP-43) gene driven by a mouse prion protein (Prnp) promoter. Line 3c was generated. (J:163231)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:163231 Xu YF, et al., Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J Neurosci. 2010 Aug 11;30(32):10851-9
• All: 6 reference(s)