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Tusc3 Gene Detail
Summary
  • Symbol
    Tusc3
  • Name
    tumor suppressor candidate 3
  • Synonyms
    MGC:6989
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933134
    NCBI Gene: 80286
  • Gene Overview
    MyGene.info: TUSC3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:39005845-39165114 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM, cytoband B1.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933134
protein coding gene Chr8:39005468-39165640 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033548
protein coding gene Chr8:37801551-37945560 (+)
A/J MGP_AJ_G0033528
protein coding gene Chr8:36359441-36500718 (+)
AKR/J MGP_AKRJ_G0033452
protein coding gene Chr8:37455714-37599584 (+)
BALB/cJ MGP_BALBcJ_G0033524
protein coding gene Chr8:36446572-36594787 (+)
C3H/HeJ MGP_C3HHeJ_G0033236
protein coding gene Chr8:37837424-37977104 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034040
protein coding gene Chr8:39223592-39366511 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030989
protein coding gene Chr8:33063796-33203693 (+)
CAST/EiJ MGP_CASTEiJ_G0032564
protein coding gene Chr8:37322135-37463292 (+)
CBA/J MGP_CBAJ_G0033214
protein coding gene Chr8:40817741-40968019 (+)
DBA/2J MGP_DBA2J_G0033367
protein coding gene Chr8:36232004-36369811 (+)
FVB/NJ MGP_FVBNJ_G0033312
protein coding gene Chr8:35817912-35955076 (+)
LP/J MGP_LPJ_G0033457
protein coding gene Chr8:37832331-37977975 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033354
protein coding gene Chr8:40574404-40727832 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034059
protein coding gene Chr8:37587066-37732414 (+)
PWK/PhJ MGP_PWKPhJ_G0032273
protein coding gene Chr8:35774003-35916170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032105
protein coding gene Chr8:36797569-36951946 (+)
WSB/EiJ MGP_WSBEiJ_G0032679
protein coding gene Chr8:37824084-37963965 (+)



Homology
more
  • Human Ortholog
    TUSC3, tumor suppressor candidate 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TUSC3, tumor suppressor candidate 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D8S1992, M33, MagT2, MRT22, MRT7, N33, OST3A
  • Links
    NCBI Gene ID: 7991
    neXtProt AC: NX_Q13454
    UniProt: Q13454

  • Chr Location
    8p22; chr8:15540087-15766649 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6937
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TUSC3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TUSC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039530 Ensembl Gene Model | MGI Sequence Detail 159270 C57BL/6J ±  kb
transcript ENSMUST00000167992 Ensembl | MGI Sequence Detail 1511 Not Applicable  
polypeptide ENSMUSP00000126080 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142704
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory