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Tusc3
Gene Detail
Symbol

Name
ID
Tusc3
tumor suppressor candidate 3
MGI:1933134
Synonyms
MGC:6989
Feature Type
protein coding gene
Genetic Map
Chromosome 8
23.89 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:39005867-39165112 bp, + strand
From Ensembl annotation of GRCm38

  159246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6937  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TUSC3
Gene Tree: Tusc3

Human
homologs
TUSC3, tumor suppressor candidate 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7991
neXtProt AC: NX_Q13454

Human Synonyms: D8S1992, M33, MRT22, MRT7, N33, OST3A

Human Chr (Location): 8p22; chr8:15540087-15766649 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TUSC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Endonuclease-mediated(1) Gene trapped(14) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tusc3 interacts with 186 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (169)    Tissues (109)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
RT-PCR 4
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tusc3 ; ZFIN tusc3    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039530 (Evidence)
Entrez Gene 80286 (Evidence)
DFCI TC1576110, TC1592383, TC1644615
DoTS DT.101389990, DT.494603, DT.97396486
NIA Mouse Gene Index U009271
International Mouse Phenotyping Consortium Status Tusc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039530 Ensembl Gene Model | MGI Sequence Detail 159246 C57BL/6J ±  kb
transcript ENSMUST00000167992 Ensembl | MGI Sequence Detail 1511 Not Applicable 
polypeptide ENSMUSP00000126080 Ensembl | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1815 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1845)
Protein-related
information
ResourceIDDescription
InterPro IPR006844 Magnesium transporter protein 1
InterPro IPR021149 Oligosaccharyl transferase complex, subunit OST3/OST6
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016840 tumor suppressor candidate 3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGI:2142704

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory