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Tusc3 Gene Detail
Summary
  • Symbol
    Tusc3
  • Name
    tumor suppressor candidate 3
  • Synonyms
    MGC:6989
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933134
    NCBI Gene: 80286
  • Gene Overview
    MyGene.info: TUSC3
Location & Maps
more
  • Sequence Map
    Chr8:39005867-39165112 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      159246 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TUSC3, tumor suppressor candidate 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TUSC3, tumor suppressor candidate 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D8S1992, M33, MRT22, MRT7, N33, OST3A
  • Links
    NCBI Gene ID: 7991
    neXtProt AC: NX_Q13454

  • Chr Location
    8p22; chr8:15540087-15766649 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6937
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TUSC3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TUSC3 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 7; MRT7   OMIM: 611093
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    16
  • Endonuclease-mediated
    1
  • Gene trapped
    14
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039530 Ensembl Gene Model | MGI Sequence Detail 159246 C57BL/6J ±  kb
transcript ENSMUST00000167992 Ensembl | MGI Sequence Detail 1511 Not Applicable  
polypeptide ENSMUSP00000126080 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1765 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016840 tumor suppressor candidate 3
  • InterPro Domains
    IPR021149 Oligosaccharyl transferase complex, subunit OST3/OST6
    IPR013766 Thioredoxin domain
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142704
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory