Dock8
Gene Detail

Symbol Name ID

Dock8 dedicator of cytokinesis 8 MGI:1921396

Synonyms

1200017A24Rik, 5830472H07Rik, A130095G14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19

19.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:24999529-25202432 bp, + strand From NCBI annotation of GRCm38   202904 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:52414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dock8

Human homologs

Human Homolog		DOCK8, dedicator of cytokinesis 8
NCBI Gene ID		81704
neXtProt AC		NX_Q8NF50
Human Synonyms		MRD2, ZIR8
Human Chr (Location)		9p24.3; chr9:214865-465259 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DOCK8

Alleles and phenotypes

All alleles(7) : Targeted(1) Gene trapped(4) Chemically induced(2)
 

Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	small GTPase mediated signal transduction
Component	cellular_component
Function	guanyl-nucleotide exchange factor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (28)    Images (19)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	46

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) cDNA(60)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000052085 (Evidence)
Entrez Gene	76088 (Evidence)
UniGene	102485
DFCI	TC1581599, TC1589529, TC1591148, TC1599020, TC1609779, TC1632773
DoTS	DT.101720621, DT.110866540, DT.40147588, DT.55227164, DT.94282915, DT.94345301, DT.97359288
NIA Mouse Gene Index	U019319
PDB	3VHL
Consensus CDS Project	CCDS37943.1
International Mouse Knockout Project Status	Dock8

Sequences

Length	Strain/Species
genomic	76088	NCBI Gene Model | MGI Sequence Detail	202904	C57BL/6J
transcript	NM_028785	RefSeq | MGI Sequence Detail	7810	C57BL/6
polypeptide	Q8C147	UniProt | EBI | MGI Sequence Detail	2100	Not Applicable

All sequences(38) RefSeq(3) UniProt(2)

Polymorphisms

SNPs(1533 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026791	Dedicator of cytokinesis
InterPro	IPR026798	Dedicator of cytokinesis C
InterPro	IPR027007	Dedicator of cytokinesis C2 domain
InterPro	IPR021816	Dedicator of cytokinesis C/D, N-terminal
InterPro	IPR010703	Dedicator of cytokinesis C-terminal
Protein Ontology	PR:000006625	dedicator of cytokinesis protein 8

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(33)

Other accession IDs

MGI:1923338, MGI:2147551, MGI:2443467