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Dock8 Gene Detail
Summary
  • Symbol
    Dock8
  • Name
    dedicator of cytokinesis 8
  • Synonyms
    1200017A24Rik, 5830472H07Rik, A130095G14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921396
    NCBI Gene: 76088
  • Gene Overview
    MyGene.info: DOCK8
Location & Maps
more
  • Sequence Map
    Chr19:24999529-25202432 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      202904 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 19.91 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DOCK8, dedicator of cytokinesis 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DOCK8, dedicator of cytokinesis 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-205, MRD2, ZIR8
  • Links
    NCBI Gene ID: 81704
    neXtProt AC: NX_Q8NF50

  • Chr Location
    9p24.3; chr9:214865-465259 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 52414
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DOCK8
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human DOCK8 associations

Human Disease Mouse Models
       Hyper-Ige Recurrent Infection Syndrome, Autosomal Recessive   OMIM: 243700
Mental Retardation, Autosomal Dominant 2; MRD2   OMIM: 614113
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 5 alleles in 6 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    4
  • Endonuclease-mediated
    1
  • Gene trapped
    4
  • Spontaneous
    2
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052085 Ensembl Gene Model | MGI Sequence Detail 202904 C57BL/6J ±  kb
transcript ENSMUST00000025831 Ensembl | MGI Sequence Detail 7810 Not Applicable  
polypeptide ENSMUSP00000025831 Ensembl | MGI Sequence Detail 2100 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2407 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 4
Other
Accession IDs
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MGI:1923338, MGI:2147551, MGI:2443467
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:220239 Krishnaswamy JK, et al., Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory