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Dock8
Gene Detail
Symbol

Name
ID
Dock8
dedicator of cytokinesis 8
MGI:1921396
Synonyms
1200017A24Rik, 5830472H07Rik, A130095G14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
19.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:24999529-25202432 bp, + strand
From Ensembl annotation of GRCm38

  202904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dock8

Human
homologs
Human Homolog DOCK8, dedicator of cytokinesis 8
NCBI Gene ID 81704
neXtProt AC  NX_Q8NF50
Human Synonyms  HEL-205, MRD2, ZIR8
Human Chr (Location)  9p24.3; chr9:214865-465259 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human DOCK8
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(4) Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.
 
Interactions
Dock8 interacts with 241 markers (Mir17, Mir19a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process dendritic cell migration, immunological synapse formation, ...
Component cell leading edge, membrane
Function guanyl-nucleotide exchange factor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (28)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) cDNA(59)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000052085 (Evidence)
Entrez Gene76088 (Evidence)
UniGene102485
DFCITC1589529, TC1581599, TC1632773, TC1609779, TC1599020, TC1591148
DoTSDT.101720621, DT.110866540, DT.97359288, DT.94345301, DT.94282915, DT.55227164, DT.40147588
NIA Mouse Gene IndexU019319
PDB3VHL
Consensus CDS ProjectCCDS37943.1
International Mouse Knockout Project StatusDock8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052085 Ensembl Gene Model | MGI Sequence Detail 202904 C57BL/6J ±  kb
transcript ENSMUST00000025831 Ensembl | MGI Sequence Detail 7810 Not Applicable 
polypeptide ENSMUSP00000025831 Ensembl | MGI Sequence Detail 2100 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(2447 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR026791 Dedicator of cytokinesis
InterPro IPR021816 Dedicator of cytokinesis C/D, N-terminal
InterPro IPR010703 Dedicator of cytokinesis C-terminal
InterPro IPR027007 DHR-1 domain
InterPro IPR027357 DHR-2 domain
Protein Ontology PR:000006625 dedicator of cytokinesis protein 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202494 Crawford G, et al., DOCK8 is critical for the survival and function of NKT cells. Blood. 2013 Sep 19;122(12):2052-61
All references(36)
Other
accession IDs
MGI:1923338, MGI:2147551, MGI:2443467

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory