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Ppme1 Gene Detail
Summary
  • Symbol
    Ppme1
  • Name
    protein phosphatase methylesterase 1
  • Synonyms
    1110069N17Rik, 2700017M01Rik, PME-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919840
    NCBI Gene: 72590
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99975944-100021103 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.35 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    904 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919840
 protein coding gene Chr7:99975944-100021514 (-)
129S1/SvImJ ENSMUSG00200047060
 protein coding gene Chr7:86804711-86850078 (-)
A/J ENSMUSG00195053653
 protein coding gene Chr7:91310150-91355524 (-)
AKR/J ENSMUSG00220049867
 protein coding gene Chr7:84726797-84772166 (-)
BALB/cJ ENSMUSG00180028207
 protein coding gene Chr7:87983150-88028518 (-)
C3H/HeJ ENSMUSG00175023213
 protein coding gene Chr7:88633199-88677907 (-)
C57BL/6NJ ENSMUSG00215013908
 protein coding gene Chr7:87822115-87867688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030044
 protein coding gene Chr7:103010361-103056156 (-)
CAST/EiJ ENSTCUG00005052978
 protein coding gene Chr7:91227680-91273187 (-)
CBA/J ENSMUSG00210024459
 protein coding gene Chr7:88486880-88531586 (-)
DBA/2J ENSMUSG00185056628
 protein coding gene Chr7:92808318-92853019 (-)
FVB/NJ ENSMUSG00205017143
 protein coding gene Chr7:88481278-88526650 (-)
JF1/MsJ ENSUMUG00000047059
 protein coding gene Chr7:97713282-97757970 (-)
LP/J ENSMUSG00230038392
 protein coding gene Chr7:98946463-98991829 (-)
NOD/ShiLtJ ENSMUSG00190019970
 protein coding gene Chr7:88762490-88808053 (-)
NZO/HlLtJ ENSMUSG00225050335
 protein coding gene Chr7:97124447-97169813 (-)
PWK/PhJ ENSLUMG00010040390
 protein coding gene Chr7:86951835-86997388 (-)
SPRET/EiJ ENSMSPG00010009470
 protein coding gene Chr7:88190668-88247419 (-)
WSB/EiJ ENSIUOG00005009852
 protein coding gene Chr7:89111271-89156658 (-)



Homology
more
  • Human Ortholog
    PPME1, protein phosphatase methylesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPME1, protein phosphatase methylesterase 1
  • Synonyms
    ABDH19, PME-1
  • Links
    NCBI Gene ID: 51400
    UniProt: Q9Y570

  • Chr Location
    11q13.4; chr11:74171083-74254703 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene causes virtual loss of the demethylated form of phosphoprotein phosphatase 2A in the nervous system and peripheral tissues. Homozygous null mice fail to initiate normal breathing or suckling behavior and die within the first day of life.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    22
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72590 NCBI Gene Model | MGI Sequence Detail 45160 C57BL/6J ±  kb
    transcript NM_028292 RefSeq | MGI Sequence Detail 2361 C57BL/6  
    polypeptide Q8BVQ5 UniProt | EBI | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916144
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory