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Ppme1 Gene Detail
Summary
  • Symbol
    Ppme1
  • Name
    protein phosphatase methylesterase 1
  • Synonyms
    1110069N17Rik, 2700017M01Rik, PME-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919840
    NCBI Gene: 72590
Location & Maps
more
  • Sequence Map
    Chr7:100326737-100372307 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45571 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.35 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPME1, protein phosphatase methylesterase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPME1, protein phosphatase methylesterase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PME-1
  • Links
    NCBI Gene ID: 51400
    neXtProt AC: NX_Q9Y570

  • Chr Location
    11q13.4; chr11:74170891-74254703 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Ppme1
  • Incidental Mutations
Targeted disruption of this gene causes virtual loss of the demethylated form of phosphoprotein phosphatase 2A in the nervous system and peripheral tissues. Homozygous null mice fail to initiate normal breathing or suckling behavior and die within the first day of life.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059188 VEGA Gene Model | MGI Sequence Detail 45571 C57BL/6J ±  kb
transcript OTTMUST00000145255 VEGA | MGI Sequence Detail 2772 Not Applicable  
polypeptide OTTMUSP00000075703 VEGA | MGI Sequence Detail 386 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    259 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916144
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:171242 Bachovchin DA, et al., Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory