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Npff Gene Detail
Summary
  • Symbol
    Npff
  • Name
    neuropeptide FF-amide peptide precursor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891708
    NCBI Gene: 54615
  • Gene Overview
    MyGene.info: NPFF
Location & Maps
more
  • Sequence Map
    Chr15:102523839-102524942 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1104 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.65 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NPFF, neuropeptide FF-amide peptide precursor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    NPFF, neuropeptide FF-amide peptide precursor
    Orthology source: HomoloGene
  • Synonyms
    FMRFAL
  • Links
    NCBI Gene ID: 8620
    neXtProt AC: NX_O15130

  • Chr Location
    12q13.13; chr12:53506690-53507638 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Npff
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044909 VEGA Gene Model | MGI Sequence Detail 1104 C57BL/6J ±  kb
transcript OTTMUST00000118033 VEGA | MGI Sequence Detail 540 Not Applicable  
polypeptide OTTMUSP00000065923 VEGA | MGI Sequence Detail 114 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    10 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011361 FMRFamide-related neuropeptide FF
  • InterPro Domains
    IPR008065 Pro-FMRFamide-related neuropeptide FF
Molecular
Reagents
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  • All nucleic 9
    cDNA 6
    Primer pair 1
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 22
  • Earliest
    J:64690 Vilim FS, et al., Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli. Mol Pharmacol. 1999 May;55(5):804-11
  • Latest
    J:143324 Herrera-Herrera ML, et al., RFamide neuropeptides inhibit murine and human adipose differentiation. Biochem Biophys Res Commun. 2008 Dec 5;377(1):29-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory