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Txnip Gene Detail
Summary
  • Symbol
    Txnip
  • Name
    thioredoxin interacting protein
  • Synonyms
    Hyplip1, mVDUP1, THIF, VDUP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889549
    NCBI Gene: 56338
  • Gene Overview
    MyGene.info: TXNIP
Location & Maps
more
  • Sequence Map
    Chr3:96557957-96561883 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3927 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.93 cM, cytoband F2.2
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    TXNIP, thioredoxin interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TXNIP, thioredoxin interacting protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EST01027, HHCPA78, THIF, VDUP1
  • Links
    NCBI Gene ID: 10628
    neXtProt AC: NX_Q9H3M7

  • Chr Location
    1q21.1; chr1:145992435-145996631 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Txnip mouse models

Human Disease Mouse Models
       Hepatocellular Carcinoma   OMIM: 114550 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 9 alleles in 12 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Txnip
  • Incidental Mutations
Homozygous null mice display impaired natural killer cell development and activity, hyperplasia of lymphoid tissue in the ileum, and increased T cell proliferation. Lipid metabolism and blood clotting were also affected by another null mutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021271 VEGA Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
transcript OTTMUST00000050413 VEGA | MGI Sequence Detail 2827 Not Applicable  
polypeptide OTTMUSP00000023522 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016867 thioredoxin-interacting protein
  • InterPro Domains
    IPR011022 Arrestin C-terminal-like domain
    IPR011021 Arrestin-like, N-terminal
    IPR014756 Immunoglobulin E-set
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGI:1203368, MGI:1921079, MGI:2139605
References
more
  • Summaries
    All 85
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 44
  • Earliest
    J:47109 Castellani LW, et al., Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998 Apr;18(4):374-7
  • Latest
    J:230266 Gasiorek JJ, et al., Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors. Exp Hematol. 2015 May;43(5):393-403.e2

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory