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Txnip
Gene Detail
 Symbol
Name
ID
Txnip
thioredoxin interacting protein
MGI:1889549
Synonyms Hyplip1, mVDUP1, THIF, VDUP1
Feature Type protein coding gene
Genetic Map
Chromosome 3
41.93 cM, cytoband F2.2
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr3:96557957-96561883 bp, + strand
From VEGA annotation of GRCm38

  3927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38186  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Txnip

Human
homologs
Human Homolog TXNIP, thioredoxin interacting protein
NCBI Gene ID 10628
neXtProt AC  NX_Q9H3M7
Human Synonyms  EST01027, HHCPA78, THIF, VDUP1
Human Chr (Location)  1q21.1; chr1:145992435-145996631 (-)  GRCh38
Alleles
and
phenotypes
All alleles(13) : Gene trapped(4) Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display impaired natural killer cell development and activity, hyperplasia of lymphoid tissue in the ileum, and increased T cell proliferation. Lipid metabolism and blood clotting were also affected by another null mutation.
 
Human Diseases Modeled Using Mouse Txnip (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell cycle, cellular response to tumor cell, ...
Component cell, cytoplasm, ...
Function enzyme inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (178)    Tissues (100)    Images (45)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 178
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(3) cDNA(20)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021271 (Evidence)
Ensembl Gene ModelENSMUSG00000038393 (Evidence)
Entrez Gene56338 (Evidence)
DFCITC1573665, TC1588728
NIA Mouse Gene IndexU003599
Consensus CDS ProjectCCDS17640.1, CCDS38555.1
International Mouse Knockout Project StatusTxnip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021271 VEGA Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
transcript OTTMUST00000050413 VEGA | MGI Sequence Detail 2827 Not Applicable 
polypeptide OTTMUSP00000023522 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000016867 thioredoxin-interacting protein
References (Earliest) J:47109 Castellani LW, et al., Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998 Apr;18(4):374-7
(Latest) J:202036 Xu G, et al., Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nat Med. 2013 Sep;19(9):1141-6
All references(77)
Other
accession IDs
MGI:1203368, MGI:1921079, MGI:2139605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory