Txnip
Gene Detail

Symbol Name ID

Txnip thioredoxin interacting protein MGI:1889549

Synonyms

Hyplip1, mVDUP1, THIF, VDUP1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

41.93 cM, cytoband F2.2
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr3:96557957-96561883 bp, + strand From VEGA annotation of GRCm38   3927 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38186  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Txnip

Human homologs

Human Homolog		TXNIP, thioredoxin interacting protein
NCBI Gene ID		10628
neXtProt AC		NX_Q9H3M7
Human Synonyms		EST01027, HHCPA78, THIF, VDUP1
Human Chr (Location)		1q21.1; chr1:145438462-145442635 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(8) Gene trapped(4) Spontaneous(1)
 

Homozygous null mice display impaired natural killer cell development and activity, hyperplasia of lymphoid tissue in the ileum, and increased T cell proliferation. Lipid metabolism and blood clotting were also affected by another null mutation.

 
Human Diseases Modeled Using Mouse Txnip (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell cycle, cellular response to tumor cell, ...
Component	cytoplasm, mitochondrial intermembrane space, ...
Function	enzyme inhibitor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (178)    Tissues (100)    Images (45)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	178

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(3) cDNA(20)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021271 (Evidence)
Ensembl Gene Model	ENSMUSG00000038393 (Evidence)
Entrez Gene	56338 (Evidence)
DFCI	TC1573665, TC1588728
NIA Mouse Gene Index	U003599
Consensus CDS Project	CCDS17640.1, CCDS38555.1
International Mouse Knockout Project Status	Txnip

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021271	VEGA Gene Model | MGI Sequence Detail	3927	C57BL/6J
transcript	OTTMUST00000050413	VEGA | MGI Sequence Detail	2827	Not Applicable
polypeptide	OTTMUSP00000023522	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(57) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011022	Arrestin C-terminal-like domain
InterPro	IPR011021	Arrestin-like, N-terminal
InterPro	IPR014756	Immunoglobulin E-set
Protein Ontology	PR:000016867	thioredoxin-interacting protein

References

(Earliest) J:47109 Castellani LW, et al., Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998 Apr;18(4):374-7
(Latest) J:192695 Wang XQ, et al., Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Circ Res. 2012 Feb 17;110(4):560-8
All references(72)

Other accession IDs

MGI:1203368, MGI:1921079, MGI:2139605