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Txnip Gene Detail
Summary
  • Symbol
    Txnip
  • Name
    thioredoxin interacting protein
  • Synonyms
    Hyplip1, mVDUP1, THIF, VDUP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889549
    NCBI Gene: 56338
  • Gene Overview
    MyGene.info: TXNIP
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96557957-96561857 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.93 cM, cytoband F2.2
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889549
protein coding gene Chr3:96557957-96561883 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027619
protein coding gene Chr3:97435450-97439375 (+)
A/J MGP_AJ_G0027581
protein coding gene Chr3:94320306-94324243 (+)
AKR/J MGP_AKRJ_G0027548
protein coding gene Chr3:96540920-96544846 (+)
BALB/cJ MGP_BALBcJ_G0027591
protein coding gene Chr3:94132133-94136055 (+)
C3H/HeJ MGP_C3HHeJ_G0027323
protein coding gene Chr3:96843508-96847445 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028037
protein coding gene Chr3:100989296-100993222 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025378
protein coding gene Chr3:90602316-90606073 (+)
CAST/EiJ MGP_CASTEiJ_G0026778
protein coding gene Chr3:96101238-96105164 (+)
CBA/J MGP_CBAJ_G0027298
protein coding gene Chr3:104683140-104687077 (+)
DBA/2J MGP_DBA2J_G0027441
protein coding gene Chr3:93653243-93657169 (+)
FVB/NJ MGP_FVBNJ_G0027410
protein coding gene Chr3:91663586-91667523 (+)
LP/J MGP_LPJ_G0027546
protein coding gene Chr3:98721872-98725797 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027436
protein coding gene Chr3:110758004-110761930 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028091
protein coding gene Chr3:96159062-96162984 (+)
PWK/PhJ MGP_PWKPhJ_G0026503
protein coding gene Chr3:93486021-93489946 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026325
protein coding gene Chr3:94460482-94464392 (+)
WSB/EiJ MGP_WSBEiJ_G0026856
protein coding gene Chr3:96609521-96613448 (+)



Homology
more
  • Human Ortholog
    TXNIP, thioredoxin interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TXNIP, thioredoxin interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARRDC6, EST01027, HHCPA78, THIF, VDUP1
  • Links
    NCBI Gene ID: 10628
    neXtProt AC: NX_Q9H3M7
    UniProt: Q9H3M7

  • Chr Location
    1q21.1; chr1:145992426-145996631 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Txnip mouse models

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 9 alleles in 12 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired natural killer cell development and activity, hyperplasia of lymphoid tissue in the ileum, and increased T cell proliferation. Lipid metabolism and blood clotting were also affected by another null mutation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56338 NCBI Gene Model | MGI Sequence Detail 3901 C57BL/6J ±  kb
    transcript NM_001009935 RefSeq | MGI Sequence Detail 2801 C57BL/6  
    polypeptide Q8BG60 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 22
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1203368, MGI:1921079, MGI:2139605
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 6
      Diseases 3
      Gene Ontology 7
      Phenotypes 54
    • Earliest
      J:47109 Castellani LW, et al., Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998 Apr;18(4):374-7
    • Latest
      J:262387 Panse M, et al., Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms. PLoS One. 2018;13(5):e0198016

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory