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Dll4
Gene Detail
Symbol

Name
ID
Dll4
delta-like 4 (Drosophila)
MGI:1859388
Synonyms
Delta4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.97 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:119325784-119335962 bp, + strand
From VEGA annotation of GRCm38

  10179 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DLL4
Protein SuperFamily: delta-like protein
Gene Tree: Dll4

Human
homologs
DLL4, delta-like 4 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54567
neXtProt AC: NX_Q9NR61

Human Synonyms: hdelta2

Human Chr (Location): 15q14; chr15:40929333-40939060 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, absent vascular remodeling, small hearts, and embryonic growth retardation. Heterozygous null mice display background dependent partial or complete embryonic lethality, impaired vascular remodeling, and embryonic growth retardation.
 
Interactions
Dll4 interacts with 251 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process angiogenesis, blood vessel lumenization, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function calcium ion binding, Notch binding, ...
External Resources: FuncBase
Expression
Literature Summary: (103 records)
Data Summary: Results (132)    Tissues (103)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 41
In situ reporter (knock in) 65
Northern blot 12
RT-PCR 12
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DLL4 ; Xenbase dll4 ; ZFIN dll4    NEW 
Molecular
reagents
All nucleic(45) Genomic(1) cDNA(39) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015953 (Evidence)
Ensembl Gene Model ENSMUSG00000027314 (Evidence)
Entrez Gene 54485 (Evidence)
UniGene 143719
DFCI TC1584788, TC1655770, TC1596024
DoTS DT.87054645, DT.40136876
NIA Mouse Gene Index U002310
Consensus CDS Project CCDS16600.1
International Mouse Phenotyping Consortium Status Dll4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015953 VEGA Gene Model | MGI Sequence Detail 10179 C57BL/6J ±  kb
transcript OTTMUST00000037914 VEGA | MGI Sequence Detail 3747 Not Applicable 
polypeptide OTTMUSP00000017019 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001774 Delta/Serrate/lag-2 (DSL) protein
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR011651 Notch ligand, N-terminal
Protein Ontology PR:000006525 delta-like protein 4
References
(Earliest) J:62507 Shutter JR, et al., Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 2000 Jun 1;14(11):1313-8
(Latest) J:219191 Zarkada G, et al., VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):761-6
All references(175)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory