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Phenotypes Associated with This Genotype
Genotype
MGI:7545577
Allelic
Composition
Dll4tm1Frad/Dll4+
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm1Frad mutation (0 available); any Dll4 mutation (26 available)
Isl1tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 9 of 28 embryos show outflow tract alignment defects
• however, septation of the outflow tract is preserved
• in embryos with a severe ventricular septal defect
• in embryos with a shallower ventricular septal defect
• some embryos show a prominent ventricular septal defect while in others this is more shallow
• pulmonary valve arises more cranially and exits the right ventricle


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory