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Dll4tm1Frad
Targeted Allele Detail
Summary
Symbol: Dll4tm1Frad
Name: delta like canonical Notch ligand 4; targeted mutation 1, Freddy Radtke
MGI ID: MGI:3828266
Synonyms: DL4lox
Gene: Dll4  Location: Chr2:119156265-119166147 bp, + strand  Genetic Position: Chr2, 59.97 cM, cytoband E3
Alliance: Dll4tm1Frad page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143472
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into the 5' untranslated region and an frt-flanked neo cassette with a loxP site was inserted into intron 3. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 1 through 3 floxed. (J:143472)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 25 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dll4 Mutation:  26 strains or lines available
References
Original:  J:143472 Koch U, et al., Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med. 2008 Oct 27;205(11):2515-23
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory