Irf6
Gene Detail

Symbol Name ID

Irf6 interferon regulatory factor 6 MGI:1859211

Synonyms

E230028I05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

97.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:193153112-193172042 bp, + strand From VEGA annotation of GRCm38   18931 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4479  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf6

Human homologs

Human Homolog		IRF6, interferon regulatory factor 6
NCBI Gene ID		3664
neXtProt AC		NX_O14896
Human Synonyms		LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1
Human Chr (Location)		1q32.3-q41; chr1:209958968-209979520 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human IRF6

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(1) Chemically induced(1)
 

Mice with mutations of Irf6 display craniofacial, limb, and skin defects.

 
Human Diseases Modeled Using Mouse Irf6 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell cycle arrest, cell development, ...
Component	cytoplasm, nucleus
Function	DNA binding, regulatory region DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (211)    Tissues (98)    Images (30)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	196
RT-PCR	15

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) cDNA(59) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033402 (Evidence)
Ensembl Gene Model	ENSMUSG00000026638 (Evidence)
Entrez Gene	54139 (Evidence)
UniGene	273695
DFCI	TC1579045, TC1592003, TC1594338, TC1613999
DoTS	DT.101367348, DT.529132, DT.94359829
Consensus CDS Project	CCDS15632.1
International Mouse Knockout Project Status	Irf6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033402	VEGA Gene Model | MGI Sequence Detail	18931	C57BL/6J
transcript	OTTMUST00000083863	VEGA | MGI Sequence Detail	4131	Not Applicable
polypeptide	OTTMUSP00000045120	VEGA | MGI Sequence Detail	467	Not Applicable

All sequences(40) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(241 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019471	Interferon regulatory factor-3
InterPro	IPR019817	Interferon regulatory factor, conserved site
InterPro	IPR001346	Interferon regulatory factor DNA-binding domain
InterPro	IPR017855	SMAD domain-like
InterPro	IPR008984	SMAD/FHA domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000002048	interferon regulatory factor 6

References

(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:194043 Iwata J, et al., Smad4-Irf6 genetic interaction and TGFbeta-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar;140(6):1220-30
All references(62)

Other accession IDs

MGI:2138372, MGI:2443238