About   Help   FAQ
Irf6
Gene Detail
Symbol

Name
ID
Irf6
interferon regulatory factor 6
MGI:1859211
Synonyms
E230028I05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
97.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:193153111-193172040 bp, + strand
From VEGA annotation of GRCm38

  18930 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4479  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRF6
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf6

Human
homologs
IRF6, interferon regulatory factor 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3664
neXtProt AC: NX_O14896

Human Synonyms: LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1

Human Chr (Location): 1q32.3-q41; chr1:209785623-209806175 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human IRF6

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice with mutations of Irf6 display craniofacial, limb, and skin defects.
 
Human Diseases Modeled in Mice Using Irf6 (2)    Mutations Annotated to Human Diseases (3)    Phenotype Images(4)
Interactions
Irf6 interacts with 276 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle arrest, cell development, ...
Component cytoplasm, extracellular exosome, ...
Function DNA binding, regulatory region DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (206)    Tissues (95)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
RT-PCR 8
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA IRF6 ; Xenbase irf6, irf6.2 ; ZFIN irf6    NEW 
Molecular
reagents
All nucleic(60) cDNA(59) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033402 (Evidence)
Ensembl Gene Model ENSMUSG00000026638 (Evidence)
Entrez Gene 54139 (Evidence)
UniGene 273695
DFCI TC1594338, TC1613999, TC1592003, TC1579045
DoTS DT.101367348, DT.94359829, DT.529132
Consensus CDS Project CCDS15632.1
International Mouse Phenotyping Consortium Status Irf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033402 VEGA Gene Model | MGI Sequence Detail 18930 C57BL/6J ±  kb
transcript OTTMUST00000083863 VEGA | MGI Sequence Detail 4113 Not Applicable 
polypeptide OTTMUSP00000045120 VEGA | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(286 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002048 interferon regulatory factor 6
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:218835 Lane J, et al., Tak1, Smad4 and Trim33 redundantly mediate TGF-beta3 signaling during palate development. Dev Biol. 2015 Feb 15;398(2):231-41
All references(68)
Disease annotation references (3)
Other
accession IDs
MGI:2138372, MGI:2443238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory