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Irf6
Gene Detail
Symbol

Name
ID
Irf6
interferon regulatory factor 6
MGI:1859211
Synonyms
E230028I05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
97.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:193153112-193172042 bp, + strand
From VEGA annotation of GRCm38

  18931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4479  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf6

Human
homologs
Human Homolog IRF6, interferon regulatory factor 6
NCBI Gene ID 3664
neXtProt AC  NX_O14896
Human Synonyms  LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1
Human Chr (Location)  1q32.3-q41; chr1:209785623-209806175 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human IRF6
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with mutations of Irf6 display craniofacial, limb, and skin defects.
 
Human Diseases Modeled Using Mouse Irf6 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(4)
Interactions
Irf6 interacts with 277 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle arrest, cell development, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function DNA binding, regulatory region DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (206)    Tissues (95)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
RT-PCR 8
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) cDNA(59) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033402 (Evidence)
Ensembl Gene ModelENSMUSG00000026638 (Evidence)
Entrez Gene54139 (Evidence)
UniGene273695
DFCITC1592003, TC1594338, TC1579045, TC1613999
DoTSDT.101367348, DT.529132, DT.94359829
Consensus CDS ProjectCCDS15632.1
International Mouse Knockout Project StatusIrf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033402 VEGA Gene Model | MGI Sequence Detail 18931 C57BL/6J ±  kb
transcript OTTMUST00000083863 VEGA | MGI Sequence Detail 4131 Not Applicable 
polypeptide OTTMUSP00000045120 VEGA | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(7) UniProt(7)
Polymorphisms
SNPs within 2kb(286 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002048 interferon regulatory factor 6
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:209623 Kurosaka H, et al., Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest. 2014 Apr 1;124(4):1660-71
All references(65)
Disease annotation references (3)
Other
accession IDs
MGI:2138372, MGI:2443238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory