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Gene trapped Allele Detail
Symbol: Irf6Gt(OST398253)Lex
Name: interferon regulatory factor 6; gene trap OST398253, Lexicon Genetics
MGI ID: MGI:3522096
Synonyms: Irf6gt1, Irf6Gt(VICTR48)1Bcsl
Gene: Irf6  Location: Chr1:192835419-192854331 bp, + strand  Genetic Position: Chr1, 97.6 cM
Alliance: Irf6Gt(OST398253)Lex page
Mutant Cell Line:  OST398253
Germline Transmission:  Earliest citation of germline transmission: J:94918
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
Mutation detailsThe gene trap vector VICTR48 inserted into intron 1, 36 bp from the splice donor site. The vector contained flanking long terminal repeats, splice acceptor and donor sites, the ORF for neo, stop codons, polyA signal, the PGK promoter, marker fusion transcript and OmniBank sequence tag fusion transcript. Protein was not detected in mutants by Western blot. (J:46940)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 43 assay results
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf6 Mutation:  16 strains or lines available
This mutation is present in Lexicon Genomics' gene trap-mutated ES cell line OST398253. It was generated in an unspecified 129/Sv-derived ES cell line by random insertion of the VICTR48 gene trap vector.
Original:  J:94918 Schutte B, et al., Mice that lack Irf6 exhibit skin, limb and craniofacial abnormalities. MGI Direct Data Submission. 2005;
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory