|
Symbol Name ID |
Irf6
interferon regulatory factor 6 MGI:1859211 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Sparse scalp hair |
Micrognathia |
Fibrous syngnathia |
Hypoplasia of the maxilla |
Mask-like facies |
Lower lip pit |
Thin upper lip vermilion |
Cleft upper lip |
Non-midline cleft of the upper lip |
Lip pit |
Oral synechia |
Bifid uvula |
Cleft palate |
Abnormal salivary gland morphology |
Anodontia |
Hypodontia |
Dental malocclusion |
Choanal atresia |
Underdeveloped nasal alae |
Short nose |
Absent eyebrow |
Absent eyelashes |
Blepharophimosis |
Upslanted palpebral fissure |
Ankyloblepharon |
Ablepharon |
Lower eyelid coloboma |
Ectropion |
Cicatricial lagophthalmos |
Tessier cleft |
| Disease(s) Associated with IRF6 | ||||||||||||||||||||||||||||||
| orofacial cleft 6 | ||||||||||||||||||||||||||||||
| popliteal pterygium syndrome | ||||||||||||||||||||||||||||||
| Van der Woude syndrome |
| Mouse Phenotypes | craniofacial phenotype |
abnormal craniofacial bone morphology |
abnormal cranium morphology |
absent presphenoid bone |
abnormal jaw morphology |
abnormal tooth morphology |
taurodontia |
abnormal incisor morphology |
abnormal incisor color |
abnormal molar morphology |
abnormal molar crown morphology |
abnormal molar cusp morphology |
abnormal molar root morphology |
decreased molar number |
abnormal tooth development |
abnormal enamel development |
abnormal ameloblast morphology |
abnormal enamel mineralization |
abnormal enamel morphology |
abnormal enamel rod pattern |
reduced enamel thickness |
supernumerary teeth |
abnormal Hertwig epithelial root sheath morphology |
abnormal mandibular angle morphology |
small mandible |
abnormal palatine bone horizontal plate morphology |
abnormal craniofacial development |
abnormal palate development |
failure of palatal shelf elevation |
palatal shelf fusion with tongue or mandible |
abnormal mouth morphology |
abnormal oral cavity morphology |
cleft secondary palate |
cleft palate |
glossopalatal ankylosis |
round snout |
short snout |
absent outer ear |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Irf6clft1/Irf6clft1 | |||||||||||||||||||||||||||||||||||||||
| Irf6Gt(OST398253)Lex/Irf6Gt(OST398253)Lex | |||||||||||||||||||||||||||||||||||||||
| Irf6tm1Mjd/Irf6tm1Mjd | |||||||||||||||||||||||||||||||||||||||
| Irf6tm1Pts/Irf6tm1Pts | * | ||||||||||||||||||||||||||||||||||||||
| Irf6Gt(OST398253)Lex/Irf6+ | |||||||||||||||||||||||||||||||||||||||
| Irf6tm1Mjd/Irf6+ | |||||||||||||||||||||||||||||||||||||||
| Irf6tm1Mjd/Irf6tm1Pts | * | ||||||||||||||||||||||||||||||||||||||
| Irf6tm1Bcsl/Irf6tm1Bcsl Pitx2tm4(cre)Jfm/Pitx2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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