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Mapk1
Gene Detail
Symbol

Name
ID
Mapk1
mitogen-activated protein kinase 1
MGI:1346858
Synonyms
9030612K14Rik, Erk2, MAPK2, p42mapk, Prkm1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr16:16983382-17047453 bp, + strand
From VEGA annotation of GRCm38

  64072 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPK1
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk1

Human
homologs
MAPK1, mitogen-activated protein kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5594
neXtProt AC: NX_P28482

Human Synonyms: ERK, ERK2, ERK-2, ERT1, MAPK2, p38, p40, p41, p41mapk, p42-MAPK, P42MAPK, PRKM1, PRKM2

Human Chr (Location): 22q11.21; chr22:21759657-21867680 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(18) Targeted(12) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues.
 
Human Diseases Modeled in Mice Using Mapk1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Mapk1 interacts with 420 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (105 annotations)
Process apoptotic process, B cell receptor signaling pathway, ...
Component axon, caveola, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (301 records)
Data Summary: Results (443)    Tissues (249)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 69
RNA in situ 132
Western blot 146
RT-PCR 96
cDNA source data(26)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mapk1 ; ZFIN mapk1    NEW 
Molecular
reagents
All nucleic(36) Genomic(5) cDNA(27) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000020203 (Evidence)
Ensembl Gene Model ENSMUSG00000063358 (Evidence)
Entrez Gene 26413 (Evidence)
DFCI TC1605197, TC1583982, TC1578432, TC1573574
DoTS DT.535488, DT.101388611, DT.101150642, DT.94313588
NIA Mouse Gene Index U016859
EC 2.7.11.24
Consensus CDS Project CCDS27992.1
International Mouse Phenotyping Consortium Status Mapk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020203 VEGA Gene Model | MGI Sequence Detail 64072 C57BL/6J ±  kb
transcript OTTMUST00000048169 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000022010 VEGA | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000103 mitogen-activated protein kinase 1
References
(Earliest) J:3247 L'Allemain G, et al., Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein. FEBS Lett. 1991 Nov 4;292(1-2):191-5
(Latest) J:221658 Vithayathil J, et al., Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation. J Neurosci. 2015 Apr 29;35(17):6836-48
All references(558)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33596, MGD-MRK-9584, MGI:105919, MGI:1921796, MGI:2146330, MGI:2146551, MGI:2146700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory