Mapk1
Gene Detail

Symbol Name ID

Mapk1 mitogen-activated protein kinase 1 MGI:1346858

Synonyms

9030612K14Rik, Erk2, MAPK2, p42mapk, Prkm1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr16:16983382-17047453 bp, + strand From VEGA annotation of GRCm38   64072 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk1

Human homologs

Human Homolog		MAPK1, mitogen-activated protein kinase 1
NCBI Gene ID		5594
neXtProt AC		NX_P28482
Human Synonyms		ERK, ERK2, ERT1, MAPK2, p38, p40, p41, p41mapk, P42MAPK, PRKM1, PRKM2
Human Chr (Location)		22q11.21; chr22:22113946-22221970 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(30) : Targeted(12) Gene trapped(18)
 

Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues.

 
Human Diseases Modeled Using Mouse Mapk1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (91 annotations)

Process	apoptotic process, B cell receptor signaling pathway, ...
Component	axon part, caveola, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (240 records)
Data Summary: Results (389)    Tissues (236)    Images (71)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	59
RNA in situ	132
Western blot	99
RT-PCR	99

cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(5) cDNA(27) Primer pair(4)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000020203 (Evidence)
Ensembl Gene Model	ENSMUSG00000063358 (Evidence)
Entrez Gene	26413 (Evidence)
DFCI	TC1573574, TC1578432, TC1583982, TC1605197
DoTS	DT.101150642, DT.101388611, DT.535488, DT.94313588
NIA Mouse Gene Index	U016859
EC	2.7.11.24
Consensus CDS Project	CCDS27992.1
International Mouse Knockout Project Status	Mapk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020203	VEGA Gene Model | MGI Sequence Detail	64072	C57BL/6J
transcript	OTTMUST00000047990	VEGA | MGI Sequence Detail	5099	Not Applicable
polypeptide	OTTMUSP00000021888	VEGA | MGI Sequence Detail	358	Not Applicable

All sequences(79) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(133 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008349	Mitogen-activated protein (MAP) kinase, ERK1/2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000000103	mitogen-activated protein kinase 1

References

(Earliest) J:3247 L'Allemain G, et al., Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein. FEBS Lett. 1991 Nov 4;292(1-2):191-5
(Latest) J:193958 Huh SH, et al., Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013 Feb 15;27(4):450-8
All references(474)

Other accession IDs

MGD-MRK-33596, MGD-MRK-9584, MGI:105919, MGI:1921796, MGI:2146330, MGI:2146551, MGI:2146700