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Mapk1 Gene Detail
Summary
  • Symbol
    Mapk1
  • Name
    mitogen-activated protein kinase 1
  • Synonyms
    9030612K14Rik, Erk2, MAPK2, p42mapk, Prkm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346858
    NCBI Gene: 26413
  • Gene Overview
    MyGene.info: MAPK1
Location & Maps
more
  • Sequence Map
    Chr16:16983382-17047453 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64072 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.53 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    MAPK1, mitogen-activated protein kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK1, mitogen-activated protein kinase 1
    Orthology source: HomoloGene
  • Synonyms
    ERK, ERK2, ERK-2, ERT1, MAPK2, p38, p40, p41, p41mapk, p42-MAPK, P42MAPK, PRKM1, PRKM2
  • Links
    NCBI Gene ID: 5594
    neXtProt AC: NX_P28482

  • Chr Location
    22q11.21; chr22:21759657-21867680 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Mapk1 mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Velocardiofacial Syndrome   OMIM: 192430 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 11 alleles in 13 genetic backgrounds
    40 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Gene trapped
    18
  • Targeted
    12
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020203 VEGA Gene Model | MGI Sequence Detail 64072 C57BL/6J ±  kb
transcript OTTMUST00000048169 VEGA | MGI Sequence Detail 1747 Not Applicable  
polypeptide OTTMUSP00000022010 VEGA | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000000103 mitogen-activated protein kinase 1
  • EC
  • InterPro Domains
    IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
    IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 36
    Genomic 5
    cDNA 27
    Primer pair 4

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-33596, MGD-MRK-9584, MGI:105919, MGI:1921796, MGI:2146330, MGI:2146551, MGI:2146700
References
more
  • Summaries
    All 602
    Developmental Gene Expression 336
    Diseases 2
    Gene Ontology 51
    Phenotypes 58
  • Earliest
    J:3247 L'Allemain G, et al., Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein. FEBS Lett. 1991 Nov 4;292(1-2):191-5
  • Latest
    J:229317 Zhu XJ, et al., Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis. Dev Dyn. 2016 Mar;245(3):414-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory