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Mapk1
Gene Detail
 Symbol
Name
ID
Mapk1
mitogen-activated protein kinase 1
MGI:1346858
Synonyms 9030612K14Rik, Erk2, MAPK2, p42mapk, Prkm1
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr16:16983382-17047453 bp, + strand
From VEGA annotation of GRCm38

  64072 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk1

Human
homologs
Human Homolog MAPK1, mitogen-activated protein kinase 1
NCBI Gene ID 5594
neXtProt AC  NX_P28482
Human Synonyms  ERK, ERK2, ERK-2, ERT1, MAPK2, p38, p40, p41, p41mapk, p42-MAPK, P42MAPK, PRKM1, PRKM2
Human Chr (Location)  22q11.21; chr22:21759657-21867680 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(18) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues.
 
Human Diseases Modeled Using Mouse Mapk1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Mapk1 interacts with 419 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (99 annotations)
Process apoptotic process, B cell receptor signaling pathway, ...
Component axon, caveola, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (270 records)
Data Summary: Results (415)    Tissues (242)    Images (79)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 61
RNA in situ 132
Western blot 126
RT-PCR 96
cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(5) cDNA(27) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000020203 (Evidence)
Ensembl Gene ModelENSMUSG00000063358 (Evidence)
Entrez Gene26413 (Evidence)
DFCITC1573574, TC1578432, TC1583982, TC1605197
DoTSDT.101150642, DT.101388611, DT.535488, DT.94313588
NIA Mouse Gene IndexU016859
EC2.7.11.24
Consensus CDS ProjectCCDS27992.1
International Mouse Knockout Project StatusMapk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020203 VEGA Gene Model | MGI Sequence Detail 64072 C57BL/6J ±  kb
transcript OTTMUST00000047990 VEGA | MGI Sequence Detail 5099 Not Applicable 
polypeptide OTTMUSP00000021888 VEGA | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(6) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000103 mitogen-activated protein kinase 1
References (Earliest) J:3247 L'Allemain G, et al., Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein. FEBS Lett. 1991 Nov 4;292(1-2):191-5
(Latest) J:211623 Ben-Addi A, et al., IkappaB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2394-403
All references(522)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33596, MGD-MRK-9584, MGI:105919, MGI:1921796, MGI:2146330, MGI:2146551, MGI:2146700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory