Phenotypes Associated with This Genotype

Genotype
MGI:5660194

• Allelic Composition: Mapk1^tm1Gela/Mapk1^tm1Gela; H2az2^{Tg(Wnt1-cre)11Rth}/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:144862 )

• although present in late gestation, no viable neonates are detected

craniofacial

mandible hypoplasia ( J:144862 )

short maxilla ( J:144862 )

cleft palate ( J:144862 )

cardiovascular system

persistent truncus arteriosus ( J:144862 )

• in 1 of 5 mice at E16.5

double outlet right ventricle ( J:144862 )

• in 1 of 4 mice at E17.5

ventricular septal defect ( J:144862 )

• in 2 of 5 mice at E16.5

endocrine/exocrine glands

abnormal thymus morphology ( J:144862 )

• in 1 of 5 mice at E16.5

abnormal thyroid gland morphology ( J:144862 )

• in 1 of 5 mice at E16.5

growth/size/body

cleft palate ( J:144862 )

digestive/alimentary system

cleft palate ( J:144862 )

immune system

abnormal thymus morphology ( J:144862 )

• in 1 of 5 mice at E16.5

hematopoietic system

abnormal thymus morphology ( J:144862 )

• in 1 of 5 mice at E16.5

skeleton

mandible hypoplasia ( J:144862 )

short maxilla ( J:144862 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
velocardiofacial syndrome		DOID:12583	OMIM:192430	J:144862