About   Help   FAQ
Grem1
Gene Detail
Symbol

Name
ID
Grem1
gremlin 1
MGI:1344337
Synonyms
Cktsf1b1, Drm, Grem, gremlin
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:113746164-113758646 bp, - strand
From VEGA annotation of GRCm38

  12483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GREM1
Protein SuperFamily: gremlin precursor
Gene Tree: Grem1

Human
homologs
GREM1, gremlin 1, DAN family BMP antagonist
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26585
neXtProt AC: NX_O60565

Human Synonyms: C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2

Human Chr (Location): 15q13.3; chr15:32717974-32734669 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Radiation induced(1) Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with bilateral agenesis of the kidneys and ureters, oligodactyly, limb skeletal malformations, cyanosis, dyspnea, and abnormal lung morphology.
 
Interactions
Grem1 interacts with 328 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (122 records)
Data Summary: Results (179)    Tissues (50)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 170
RT-PCR 9
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GREM1 ; Xenbase grem1 ; ZFIN grem1a    NEW 
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(13) Primer pair(3) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014814 (Evidence)
Ensembl Gene Model ENSMUSG00000074934 (Evidence)
Entrez Gene 23892 (Evidence)
UniGene 166318
DFCI TC1585089, TC1612816
DoTS DT.40179659, DT.40180357, DT.97393470
Consensus CDS Project CCDS16560.1
International Mouse Phenotyping Consortium Status Grem1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014814 VEGA Gene Model | MGI Sequence Detail 12483 C57BL/6J ±  kb
transcript OTTMUST00000035164 VEGA | MGI Sequence Detail 4148 Not Applicable 
polypeptide OTTMUSP00000015694 VEGA | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR004133 DAN
InterPro IPR017159 Gremlin precursor
Protein Ontology PR:000008227 gremlin-1
References
(Earliest) J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
(Latest) J:222290 Jiang M, et al., BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest. 2015 Apr;125(4):1557-68
All references(189)
Other
accession IDs
MGI:1344362

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory