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Grem1
Gene Detail
Symbol

Name
ID
Grem1
gremlin 1
MGI:1344337
Synonyms
Cktsf1b1, Drm, Grem, gremlin
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:113746164-113758646 bp, - strand
From VEGA annotation of GRCm38

  12483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: gremlin precursor
Gene Tree: Grem1

Human
homologs
Human Homolog GREM1, gremlin 1, DAN family BMP antagonist
NCBI Gene ID 26585
neXtProt AC  NX_O60565
Human Synonyms  CKTSF1B1, CRAC1, DAND2, DRM, GREMLIN, HMPS, IHG-2
Human Chr (Location)  15q13.3; chr15:32717974-32734669 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Radiation induced(1) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with bilateral agenesis of the kidneys and ureters, oligodactyly, limb skeletal malformations, cyanosis, dyspnea, and abnormal lung morphology.
 
Interactions
Grem1 interacts with 329 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (110 records)
Data Summary: Results (179)    Tissues (50)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 170
RT-PCR 9
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(13) Primer pair(3) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014814 (Evidence)
Ensembl Gene ModelENSMUSG00000074934 (Evidence)
Entrez Gene23892 (Evidence)
UniGene166318
DFCITC1612816, TC1585089
DoTSDT.40180357, DT.97393470, DT.40179659
Consensus CDS ProjectCCDS16560.1
International Mouse Knockout Project StatusGrem1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014814 VEGA Gene Model | MGI Sequence Detail 12483 C57BL/6J ±  kb
transcript OTTMUST00000035164 VEGA | MGI Sequence Detail 4148 Not Applicable 
polypeptide OTTMUSP00000015694 VEGA | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR004133 DAN
InterPro IPR017159 Gremlin precursor
Protein Ontology PR:000008227 gremlin-1
References
(Earliest) J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
(Latest) J:208423 Stafford DA, et al., Follistatin interacts with Noggin in the development of the axial skeleton. Mech Dev. 2014 Feb;131:78-85
All references(177)
Other
accession IDs
MGI:1344362

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory