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Grem1 Gene Detail
Summary
  • Symbol
    Grem1
  • Name
    gremlin 1, DAN family BMP antagonist
  • Synonyms
    Cktsf1b1, Drm, Grem, gremlin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344337
    NCBI Gene: 23892
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:113746164-113758646 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12483 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GREM1, gremlin 1, DAN family BMP antagonist
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GREM1, gremlin 1, DAN family BMP antagonist
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2
  • Links
    NCBI Gene ID: 26585
    neXtProt AC: NX_O60565
    UniProt: O60565

  • Chr Location
    15q13.3; chr15:32717940-32734669 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 6 alleles in 9 genetic backgrounds
    38 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with bilateral agenesis of the kidneys and ureters, oligodactyly, limb skeletal malformations, cyanosis, dyspnea, and abnormal lung morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014814 VEGA Gene Model | MGI Sequence Detail 12483 C57BL/6J ±  kb
    transcript OTTMUST00000035164 VEGA | MGI Sequence Detail 4148 Not Applicable  
    polypeptide OTTMUSP00000015694 VEGA | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      49 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 33
      Genomic 3
      cDNA 14
      Primer pair 5
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1344362
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 138
      Gene Ontology 13
      Phenotypes 54
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257510 Zhu XJ, et al., Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly. FEBS Lett. 2018 Feb;592(3):356-368

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory