Rr284 Other Genome Feature Detail

Summary

• Symbol
  Rr284
• Name
  regulatory region 284
• Synonyms
  CRM3, EC1, GCR, HMCO2

• Feature Type
  enhancer
• IDs
  MGI:7346245
• Regulates expression of
  Fmn1, Grem1 (2 regulated genes)

Location &
Maps

• Sequence Map
  Chr2:113504419-113505618 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:312378: chr2:113,674,074-113,675,273 (GRCm38) chr2:113504419-113505618 (GRCm39)

• Genetic Map
  Chromosome 2, Syntenic

Strain
Comparison

• SNPs within 2kb
  101 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  2
• Genomic Mutations
  1 involving Rr284
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 4

  Phenotypes 2
• Earliest
  J:91385 Zuniga A, et al., Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 2004 Jul 1;18(13):1553-64
• Latest
  J:361878 Palacio V, et al., Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities. Nat Commun. 2025 Jan 31;16(1):1226

Rr284 regulates expression of:

Feature	Feature Type	Location	Reference
Fmn1, formin 1	protein coding gene	Chr2:113158081-113547112 (+)	J:312378
Grem1, gremlin 1, DAN family BMP antagonist	protein coding gene	Chr2:113579020-113588993 (-)	J:312378