Symbol
Name
ID

Grem1
gremlin 1, DAN family BMP antagonist
MGI:1344337

Phenotype annotations related to limbs/digits/tail

Darker colors indicate more annotations

Mouse Phenotypes

abnormal apical ectodermal ridge morphology

abnormal limb bud morphology

abnormal forelimb bud morphology

abnormal limb mesenchyme morphology

abnormal limb morphology

abnormal digit morphology

abnormal hallux morphology

polyphalangy

brachydactyly

oligodactyly

forelimb oligodactyly

polydactyly

postaxial polydactyly

preaxial polydactyly

syndactyly

triphalangia

abnormal forelimb morphology

fused radius and ulna

absent forelimb

abnormal hindlimb morphology

bowed femur

abnormal fibula morphology

absent fibula

short fibula

abnormal tibia morphology

bowed tibia

absent hindlimb

abnormal limb long bone morphology

fused metacarpal bones

abnormal limb development

Availability

Mouse Genotype

Grem1^ld/Grem1^ld

Grem1^tm1Azun/Grem1^tm1Azun

Grem1^tm1Rmh/Grem1^tm1Rmh

Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor^{tm1(Grem1)Svok}
Tg(Hoxb6-cre/ERT)1Smac/0 (conditional)

Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(Grem1)Svok} (conditional)

Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺
Tg(Prrx1-cre)1Cjt/0 (conditional)

Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺
Shh^{tm1(EGFP/cre)Cjt}/0 (conditional)

Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺
Tg(Hoxb6-cre/ERT)1Smac/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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