Pdk2 MGI Mouse Gene Detail - MGI:1343087 - pyruvate dehydrogenase kinase, isoenzyme 2

Symbol

Pdk2
Name

pyruvate dehydrogenase kinase, isoenzyme 2

Feature Type

protein coding gene
IDs

MGI:1343087
NCBI Gene: 18604
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:94917084-94932180 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

2 experiments

SNPs within 2kb

128 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1343087	protein coding gene	Chr11:94917084-94932197 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018975	protein coding gene	Chr11:97212127-97227223 (-)
A/J	MGP_AJ_G0018943	protein coding gene	Chr11:93285957-93301012 (-)
AKR/J	MGP_AKRJ_G0018913	protein coding gene	Chr11:96174331-96189395 (-)
BALB/cJ	MGP_BALBcJ_G0018916	protein coding gene	Chr11:93757375-93772492 (-)
C3H/HeJ	MGP_C3HHeJ_G0018730	protein coding gene	Chr11:96299257-96314327 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019368	protein coding gene	Chr11:100274327-100289423 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016999	protein coding gene	Chr11:90772267-90787448 (-)
CAST/EiJ	MGP_CASTEiJ_G0018284	protein coding gene	Chr11:97089342-97104425 (-)
CBA/J	MGP_CBAJ_G0018701	protein coding gene	Chr11:104368595-104383568 (-)
DBA/2J	MGP_DBA2J_G0018809	protein coding gene	Chr11:92860518-92875613 (-)
FVB/NJ	MGP_FVBNJ_G0018798	protein coding gene	Chr11:92322595-92337718 (-)
LP/J	MGP_LPJ_G0018879	protein coding gene	Chr11:97773461-97789844 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018825	protein coding gene	Chr11:104423260-104438377 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019408	protein coding gene	Chr11:96432630-96447761 (-)
PWK/PhJ	MGP_PWKPhJ_G0018055	protein coding gene	Chr11:93773703-93788878 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017844	protein coding gene	Chr11:96117596-96131408 (-)
WSB/EiJ	MGP_WSBEiJ_G0018333	protein coding gene	Chr11:96349870-96364987 (-)

Human Ortholog

PDK2, pyruvate dehydrogenase kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDK2, pyruvate dehydrogenase kinase 2
Synonyms

PDHK2, PDKII
Links

HGNC:8810

NCBI Gene ID: 5164

neXtProt AC: NX_Q15119

UniProt: Q15119
Chr Location

17q21.33; chr17:50094737-50111369 (+) GRCh38.p7

Alliance of Genome Resources

Pdk2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PDK2
Gene Tree

Pdk2

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Pdk2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased muscle contractile force.

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All GO Annotations

42
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

674
Tissues

1
cDNA Data

122
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pdk2b

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Pdk2 interacts with 150 markers (Mir17, Mir20b, Mir25, ...) View All

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All Sequences

48
RefSeq

4
UniProt

1
CCDS

CCDS25270.1

Ensembl

ENSMUSG00000038967 (Evidence)
NCBI Gene

18604

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000038967	Ensembl Gene Model \| MGI Sequence Detail	15097	C57BL/6J	± kb

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UniProt

1 Sequence
Protein Ontology

PR:000012505 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

(term hierarchy)
EC

2.7.11.2
InterPro Domains

IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily

IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

IPR005467 Histidine kinase domain

IPR003594 Histidine kinase/HSP90-like ATPase

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR039028 PDK/BCKDK protein kinase

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All nucleic 125

Genomic 1

cDNA 122

Primer pair 2

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 19
Earliest

J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
Latest

J:303714 Heinemann-Yerushalmi L, et al., BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development. Dev Cell. 2021 Mar 23;

TSS for Pdk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110250	Chr11:94932217-94932233 (-)	-45 bp
Tssr110249	Chr11:94932161-94932200 (-)	-1 bp
Tssr110248	Chr11:94932134-94932156 (-)	35 bp
Tssr110247	Chr11:94932102-94932123 (-)	67 bp
Tssr110246	Chr11:94932092-94932097 (-)	85 bp
Tssr110245	Chr11:94931405-94931436 (-)	759 bp
Tssr110244	Chr11:94931374-94931391 (-)	797 bp
Tssr110243	Chr11:94931332-94931369 (-)	829 bp
Tssr110242	Chr11:94923814-94923819 (-)	8,363 bp
Tssr110241	Chr11:94919568-94919596 (-)	12,598 bp
Tssr110240	Chr11:94917525-94917540 (-)	14,647 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/17/2022 MGI 6.19