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Pdk2 Gene Detail
Summary
  • Symbol
    Pdk2
  • Name
    pyruvate dehydrogenase kinase, isoenzyme 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343087
    NCBI Gene: 18604
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94917084-94932180 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    811 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343087
 protein coding gene Chr11:94917084-94932197 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018975
 protein coding gene Chr11:97212127-97227223 (-)
A/J MGP_AJ_G0018943
 protein coding gene Chr11:93285957-93301012 (-)
AKR/J MGP_AKRJ_G0018913
 protein coding gene Chr11:96174331-96189395 (-)
BALB/cJ MGP_BALBcJ_G0018916
 protein coding gene Chr11:93757375-93772492 (-)
C3H/HeJ MGP_C3HHeJ_G0018730
 protein coding gene Chr11:96299257-96314327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019368
 protein coding gene Chr11:100274327-100289423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016999
 protein coding gene Chr11:90772267-90787448 (-)
CAST/EiJ MGP_CASTEiJ_G0018284
 protein coding gene Chr11:97089342-97104425 (-)
CBA/J MGP_CBAJ_G0018701
 protein coding gene Chr11:104368595-104383568 (-)
DBA/2J MGP_DBA2J_G0018809
 protein coding gene Chr11:92860518-92875613 (-)
FVB/NJ MGP_FVBNJ_G0018798
 protein coding gene Chr11:92322595-92337718 (-)
LP/J MGP_LPJ_G0018879
 protein coding gene Chr11:97773461-97789844 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018825
 protein coding gene Chr11:104423260-104438377 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019408
 protein coding gene Chr11:96432630-96447761 (-)
PWK/PhJ MGP_PWKPhJ_G0018055
 protein coding gene Chr11:93773703-93788878 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017844
 protein coding gene Chr11:96117596-96131408 (-)
WSB/EiJ MGP_WSBEiJ_G0018333
 protein coding gene Chr11:96349870-96364987 (-)



Homology
more
  • Human Ortholog
    PDK2, pyruvate dehydrogenase kinase 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDK2, pyruvate dehydrogenase kinase 2
  • Synonyms
    PDHK2, PDKII
  • Links
    NCBI Gene ID: 5164
    UniProt: Q15119

  • Chr Location
    17q21.33; chr17:50094737-50112152 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased muscle contractile force.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    8
  • cDNA Data
    122
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038967 Ensembl Gene Model | MGI Sequence Detail 15097 C57BL/6J ±  kb
    transcript ENSMUST00000038431 Ensembl | MGI Sequence Detail 2246 Not Applicable  
    polypeptide ENSMUSP00000041447 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000012505 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
      (term hierarchy)
    • EC
      2.7.11.2
    • InterPro Domains
      IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
      IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
      IPR005467 Histidine kinase domain
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR039028 PDK/BCKDK protein kinase
    • GlyGen
      Q9JK42 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 1
      cDNA 122
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 7
      Gene Ontology 16
      Phenotypes 25
    • Earliest
      J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
    • Latest
      J:366814 Kasprzyk-Pawelec A, et al., Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53. Cell Death Differ. 2025 May;32(5):818-836
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory