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Pdk2 Gene Detail
Summary
  • Symbol
    Pdk2
  • Name
    pyruvate dehydrogenase kinase, isoenzyme 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343087
    NCBI Gene: 18604
  • Gene Overview
    MyGene.info: PDK2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:95026258-95041354 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15097 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDK2, pyruvate dehydrogenase kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDK2, pyruvate dehydrogenase kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PDHK2, PDKII
  • Links
    NCBI Gene ID: 5164
    neXtProt AC: NX_Q15119
    UniProt: Q15119

  • Chr Location
    17q21.33; chr17:50094737-50111369 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased muscle contractile force.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    121
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001622 VEGA Gene Model | MGI Sequence Detail 15097 C57BL/6J ±  kb
transcript OTTMUST00000003175 VEGA | MGI Sequence Detail 2246 Not Applicable  
polypeptide OTTMUSP00000001538 VEGA | MGI Sequence Detail 407 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    151 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012505 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    (term hierarchy)
  • EC
    2.7.11.2
  • InterPro Domains
    IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
    IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    IPR005467 Histidine kinase domain
    IPR003594 Histidine kinase/HSP90-like ATPase
    IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Molecular
Reagents
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  • All nucleic 124
    Genomic 1
    cDNA 121
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
  • Latest
    J:247017 Go Y, et al., Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis. Diabetes. 2016 Oct;65(10):2876-87
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2018
MGI 6.12 		The Jackson Laboratory