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Ppargc1a
Gene Detail
Symbol

Name
ID
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
MGI:1342774
Synonyms
A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
27.02 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:51454249-51567725 bp, - strand
From VEGA annotation of GRCm38

  113477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Ppargc1a

Human
homologs
Human Homolog PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
NCBI Gene ID 10891
neXtProt AC  NX_Q9UBK2
Human Synonyms  LEM6, PGC1, PGC1A, PGC-1(alpha), PGC-1v, PPARGC1
Human Chr (Location)  4p15.1; chr4:23792021-24091635 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from APF )
 
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
 
Phenotype Images(3)
Interactions
Ppargc1a interacts with 501 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process cellular response to oxidative stress, circadian regulation of gene expression, ...
Component cytosol, nucleus
Function chromatin binding, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (286)    Tissues (102)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 256
Northern blot 15
RT-PCR 15
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(44) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000022759 (Evidence)
Ensembl Gene ModelENSMUSG00000029167 (Evidence)
Entrez Gene19017 (Evidence)
UniGene259072
DoTSDT.94372371, DT.110633996, DT.55142570, DT.487055
NIA Mouse Gene IndexU295674, U026194
PDB3F7D
Consensus CDS ProjectCCDS19282.1
International Mouse Knockout Project StatusPpargc1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022759 VEGA Gene Model | MGI Sequence Detail 113477 C57BL/6J ±  kb
transcript OTTMUST00000054635 VEGA | MGI Sequence Detail 6464 Not Applicable 
polypeptide OTTMUSP00000026095 VEGA | MGI Sequence Detail 797 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(15) UniProt(11)
Polymorphisms
SNPs within 2kb(771 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000013059 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
References
(Earliest) J:46531 Puigserver P, et al., A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20;92(6):829-39
(Latest) J:214735 Hasumi Y, et al., Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation. Hum Mol Genet. 2014 Nov 1;23(21):5706-19
All references(215)
Other
accession IDs
MGI:1203734, MGI:2443650, MGI:3779388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory