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Ppargc1a Gene Detail
Summary
  • Symbol
    Ppargc1a
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  • Synonyms
    A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342774
    NCBI Gene: 19017
  • Gene Overview
    MyGene.info: PPARGC1A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:51454250-51567726 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.02 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342774
protein coding gene Chr5:51454249-52116058 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029542
protein coding gene Chr5:50385447-50504929 (-)
A/J MGP_AJ_G0029510
protein coding gene Chr5:48612772-48729002 (-)
AKR/J MGP_AKRJ_G0029458
protein coding gene Chr5:50269993-50386804 (-)
BALB/cJ MGP_BALBcJ_G0029519
protein coding gene Chr5:49083021-49197664 (-)
C3H/HeJ MGP_C3HHeJ_G0029242
protein coding gene Chr5:50444384-50561568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029973
protein coding gene Chr5:52521630-52642764 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027213
protein coding gene Chr5:45413480-45520773 (-)
CAST/EiJ MGP_CASTEiJ_G0028650
protein coding gene Chr5:49414923-49538655 (-)
CBA/J MGP_CBAJ_G0029211
protein coding gene Chr5:54118438-54244511 (-)
DBA/2J MGP_DBA2J_G0029357
protein coding gene Chr5:48684330-48797559 (-)
FVB/NJ MGP_FVBNJ_G0029317
protein coding gene Chr5:48005860-48133211 (-)
LP/J MGP_LPJ_G0029442
protein coding gene Chr5:50852410-50969785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029345
protein coding gene Chr5:55223655-55367804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030006
protein coding gene Chr5:49771235-49890895 (-)
PWK/PhJ MGP_PWKPhJ_G0028374
protein coding gene Chr5:47734159-47850912 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028208
protein coding gene Chr5:49181255-49298961 (-)
WSB/EiJ MGP_WSBEiJ_G0028731
protein coding gene Chr5:49810410-49929958 (-)



Homology
more
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LEM6, PGC1, PGC1A, PGC-1alpha, PGC-1(alpha), PGC-1v, PPARGC1
  • Links
    NCBI Gene ID: 10891
    neXtProt AC: NX_Q9UBK2
    UniProt: Q9UBK2

  • Chr Location
    4p15.2; chr4:23792021-24472975 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Ppargc1a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    121 phenotypes from 10 alleles in 16 genetic backgrounds
    31 phenotypes from multigenic genotypes
    3 images
    182 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029167 Ensembl Gene Model | MGI Sequence Detail 113477 C57BL/6J ±  kb
    transcript ENSMUST00000132734 Ensembl | MGI Sequence Detail 6464 Not Applicable  
    polypeptide ENSMUSP00000117040 Ensembl | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013059 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    • PDB
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034625 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
      IPR034605 PGC-1
      IPR034833 PGC-1alpha, RNA recognition motif
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 46
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1203734, MGI:2443650, MGI:3779388
    References
    more
    • Summaries
      All 428
      Developmental Gene Expression 50
      Diseases 1
      Gene Ontology 34
      Phenotypes 182
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:265063 Karlsson L, et al., Constitutive PGC-1alpha Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke. Neuroscience. 2018 Aug 1;384:314-328

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory