Ppargc1a
Gene Detail

Symbol Name ID

Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha MGI:1342774

Synonyms

A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

27.02 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:51454249-51567725 bp, - strand From VEGA annotation of GRCm38   113477 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ppargc1a

Human homologs

Human Homolog		PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
NCBI Gene ID		10891
neXtProt AC		NX_Q9UBK2
Human Synonyms		LEM6, PGC1, PGC1A, PGC-1(alpha), PGC-1v, PPARGC1
Human Chr (Location)		4p15.1; chr4:23793644-23891700 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	cellular response to oxidative stress, mitochondrion organization, ...
Component	cytosol, nucleus
Function	chromatin binding, chromatin DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (286)    Tissues (100)    Images (35)
Theiler Stages: 15, 17, 19, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	256
Northern blot	15
RT-PCR	15

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) cDNA(44) Primer pair(3) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000022759 (Evidence)
Ensembl Gene Model	ENSMUSG00000029167 (Evidence)
Entrez Gene	19017 (Evidence)
UniGene	259072
DoTS	DT.110633996, DT.487055, DT.55142570, DT.94372371
NIA Mouse Gene Index	U026194, U295674
PDB	3F7D
Consensus CDS Project	CCDS19282.1
International Mouse Knockout Project Status	Ppargc1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022759	VEGA Gene Model | MGI Sequence Detail	113477	C57BL/6J
transcript	OTTMUST00000054635	VEGA | MGI Sequence Detail	6464	Not Applicable
polypeptide	OTTMUSP00000026095	VEGA | MGI Sequence Detail	797	Not Applicable

All sequences(47) RefSeq(3) UniProt(7)

Polymorphisms

SNPs(525 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000013059	peroxisome proliferator-activated receptor gamma coactivator 1-alpha

References

(Earliest) J:46531 Puigserver P, et al., A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20;92(6):829-39
(Latest) J:194191 Shoag J, et al., PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10;49(1):145-57
All references(171)

Other accession IDs

MGI:1203734, MGI:2443650, MGI:3779388