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Ppargc1a Gene Detail
Summary
  • Symbol
    Ppargc1a
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  • Synonyms
    A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342774
    NCBI Gene: 19017
  • Gene Overview
    MyGene.info: PPARGC1A
Location & Maps
more
  • Sequence Map
    Chr5:51454250-51567726 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113477 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.02 cM, cytoband C1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
    Orthology source: HomoloGene
  • Synonyms
    LEM6, PGC1, PGC1A, PGC-1alpha, PGC-1(alpha), PGC-1v, PPARGC1
  • Links
    NCBI Gene ID: 10891
    neXtProt AC: NX_Q9UBK2

  • Chr Location
    4p15.1; chr4:23792021-24472771 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 8 alleles in 13 genetic backgrounds
    31 phenotypes from multigenic genotypes
    3 images
    154 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    9
  • Transgenic
    3
  • Genomic Mutations
    4 involving Ppargc1a
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022759 VEGA Gene Model | MGI Sequence Detail 113477 C57BL/6J ±  kb
transcript OTTMUST00000054635 VEGA | MGI Sequence Detail 6464 Not Applicable  
polypeptide OTTMUSP00000026095 VEGA | MGI Sequence Detail 797 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4121 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013059 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  • PDB
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 50
    cDNA 44
    Primer pair 5
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1203734, MGI:2443650, MGI:3779388
References
more
  • Summaries
    All 248
    Developmental Gene Expression 39
    Gene Ontology 29
    Phenotypes 154
  • Earliest
    J:46531 Puigserver P, et al., A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20;92(6):829-39
  • Latest
    J:232408 Van De Pette M, et al., Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. PLoS Genet. 2016 Mar;12(3):e1005916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory