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Ppargc1a Gene Detail
Summary
  • Symbol
    Ppargc1a
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  • Synonyms
    A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342774
    NCBI Gene: 19017
  • Gene Overview
    MyGene.info: PPARGC1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:51454250-51567726 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113477 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.02 cM, cytoband C1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LEM6, PGC1, PGC1A, PGC-1alpha, PGC-1(alpha), PGC-1v, PPARGC1
  • Links
    NCBI Gene ID: 10891
    neXtProt AC: NX_Q9UBK2
    UniProt: Q9UBK2

  • Chr Location
    4p15.2; chr4:23792021-24472975 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Ppargc1a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    121 phenotypes from 10 alleles in 16 genetic backgrounds
    31 phenotypes from multigenic genotypes
    3 images
    179 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022759 VEGA Gene Model | MGI Sequence Detail 113477 C57BL/6J ±  kb
    transcript OTTMUST00000054635 VEGA | MGI Sequence Detail 6464 Not Applicable  
    polypeptide OTTMUSP00000026095 VEGA | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4121 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013059 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    • PDB
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034625 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
      IPR034605 PGC-1
      IPR034833 PGC-1alpha, RNA recognition motif
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 46
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1203734, MGI:2443650, MGI:3779388
    References
    more
    • Summaries
      All 424
      Developmental Gene Expression 50
      Diseases 1
      Gene Ontology 33
      Phenotypes 179
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:264271 Zhang M, et al., Pgc-1alpha repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice. Dis Model Mech. 2018 Aug 16;11(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory