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Ppargc1a Gene Detail
Summary
  • Symbol
    Ppargc1a
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  • Synonyms
    A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342774
    NCBI Gene: 19017
Location & Maps
more
  • Sequence Map
    Chr5:51454250-51567726 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113477 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
    Orthology source: HomoloGene
  • Synonyms
    LEM6, PGC1, PGC1A, PGC-1(alpha), PGC-1v, PPARGC1
  • Links
    NCBI Gene ID: 10891
    neXtProt AC: NX_Q9UBK2

  • Chr Location
    4p15.1; chr4:23792021-24472771 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 8 alleles in 13 genetic backgrounds
    31 phenotypes from multigenic genotypes
    3 images
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    9
  • Transgenic
    3
  • Genomic Mutations
    4 involving Ppargc1a
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022759 VEGA Gene Model | MGI Sequence Detail 113477 C57BL/6J ±  kb
transcript OTTMUST00000054635 VEGA | MGI Sequence Detail 6464 Not Applicable  
polypeptide OTTMUSP00000026095 VEGA | MGI Sequence Detail 797 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    771 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013059 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  • PDB
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 48
    cDNA 44
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1203734, MGI:2443650, MGI:3779388
References
more
  • Summaries
    All 241
    Developmental Gene Expression 37
    Gene Ontology 29
    Phenotypes 149
  • Earliest
    J:46531 Puigserver P, et al., A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20;92(6):829-39
  • Latest
    J:227848 Bartley AF, et al., Interneuron Transcriptional Dysregulation Causes Frequency-Dependent Alterations in the Balance of Inhibition and Excitation in Hippocampus. J Neurosci. 2015 Nov 18;35(46):15276-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory