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Phenotypes Associated with This Genotype
Genotype
MGI:4429501
Allelic
Composition
Tg(Myh6-rtTA)8585Jam/0
Tg(tetO-Ppargc1a)1Dpk/0
Genetic
Background
involves: FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-rtTA)8585Jam mutation (1 available)
Tg(tetO-Ppargc1a)1Dpk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• following doxycycline treatment, adult mice exhibit eccentric hypertrophy unlike in wild-type mice

cardiovascular system
• following doxycycline treatment of neonates, myofibril mitochondria density is increased 3.5-fold compared with wild-type myofibrils due to increased biogenesis
• doxycycline-treated adult mice exhibit an increased in mitochondrial biogenesis in myofibrils compared with wild-type mice but not to the extent observed in doxycycline treated neonates
• however, removal of doxycycline restores normal mitochondria
• following doxycycline treatment, adult mice exhibit eccentric hypertrophy unlike in wild-type mice
• 2 week after doxycycline treatment, adult mice exhibit increased end-diastolic and end-systolic left ventricle diameter and a mild increase in left ventricular wall thickness compared with wild-type mice
• following doxycycline treatment of adult mice
• following doxycycline treatment of adult mice
• however, removal of doxycycline restores cardiac muscle contractility
• following doxycycline treatment, adult mice exhibit decreased fractional shortening compared with wild-type mice
• following doxycycline treatment of adult mice
• following removal of doxycycline
• following induction of expression with doxycycline, adult mice exhibit reversible cardiomyopathy unlike wild-type mice
• however, no increase in cardiac cell apoptosis is observed

cellular
• following doxycycline treatment, adult mice exhibit an increase in mitochondrial number along with mitochondrial ultrastructural abnormalities unlike in wild-type mice
• following doxycycline treatment of neonates, myofibril mitochondria density is increased 3.5-fold compared with wild-type myofibrils due to increased biogenesis
• doxycycline-treated adult mice exhibit an increased in mitochondrial biogenesis in myofibrils compared with wild-type mice but not to the extent observed in doxycycline treated neonates
• however, removal of doxycycline restores normal mitochondria

muscle
• following doxycycline treatment of neonates, myofibril mitochondria density is increased 3.5-fold compared with wild-type myofibrils due to increased biogenesis
• doxycycline-treated adult mice exhibit an increased in mitochondrial biogenesis in myofibrils compared with wild-type mice but not to the extent observed in doxycycline treated neonates
• however, removal of doxycycline restores normal mitochondria
• following doxycycline treatment, adult mice exhibit decreased fractional shortening compared with wild-type mice
• however, removal of doxycycline restores cardiac muscle contractility
• following induction of expression with doxycycline, adult mice exhibit reversible cardiomyopathy unlike wild-type mice
• however, no increase in cardiac cell apoptosis is observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:96614
congestive heart failure DOID:6000 J:96614


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/14/2023
MGI 6.22
The Jackson Laboratory