Mmp13
Gene Detail

Symbol Name ID

Mmp13 matrix metallopeptidase 13 MGI:1340026

Synonyms

Clg, collagenase-1, Collagenase-3, interstitial collagenase, Mmp1, MMP-13

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:7272514-7283333 bp, + strand From NCBI annotation of GRCm38   10820 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp13

Human homologs

Human Homolog		MMP13, matrix metallopeptidase 13 (collagenase 3)
NCBI Gene ID		4322
neXtProt AC		NX_P45452
Human Synonyms		CLG3, MANDP1
Human Chr (Location)		11q22.3; chr11:102813721-102826463 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MMP13

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice display increased width of hypertrophic chondrocyte zone and increased trabecular bone.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	bone mineralization, cartilage development, ...
Component	extracellular matrix, extracellular region, ...
Function	calcium-dependent protein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (92 records)
Data Summary: Results (84)    Tissues (51)    Images (20)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	58
Northern blot	5
Western blot	3
RT-PCR	10

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(1) cDNA(24) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000050578 (Evidence)
Entrez Gene	17386 (Evidence)
UniGene	5022
DFCI	TC1577492
DoTS	DT.40176878
NIA Mouse Gene Index	U052600
EC	3.4.24.-, 3.4.24.7
PDB	1CXV
Consensus CDS Project	CCDS22803.1
International Mouse Knockout Project Status	Mmp13

Sequences

Length	Strain/Species
genomic	17386	NCBI Gene Model | MGI Sequence Detail	10820	C57BL/6J
transcript	NM_008607	RefSeq | MGI Sequence Detail	2675	C57BL/6
polypeptide	P33435	UniProt | EBI | MGI Sequence Detail	472	Not Applicable

All sequences(28) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR016293	Peptidase M10A, metazoans
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010473	collagenase 3

Graphical View of Protein Domain Structure

References

(Earliest) J:2506 Henriet P, et al., Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases. FEBS Lett. 1992 Sep 28;310(2):175-8
(Latest) J:193842 Lu C, et al., Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 2013 Apr;53(2):566-74
All references(159)

Other accession IDs

MGD-MRK-12276, MGD-MRK-2012, MGI:97006