About   Help   FAQ
Mmp13
Gene Detail
Symbol

Name
ID
Mmp13
matrix metallopeptidase 13
MGI:1340026
Synonyms
Clg, collagenase-1, Collagenase-3, interstitial collagenase, Mmp1, MMP-13
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7272514-7283333 bp, + strand
From NCBI annotation of GRCm38

  10820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMP13
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp13

Human
homologs
MMP13, matrix metallopeptidase 13
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4322
neXtProt AC: NX_P45452

Human Synonyms: CLG3, MANDP1, MMP-13

Human Chr (Location): 11q22.3; chr11:102942992-102955734 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MMP13

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased width of hypertrophic chondrocyte zone and increased trabecular bone.
 
Phenotype Images(2)
Interactions
Mmp13 interacts with 203 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process bone mineralization, bone morphogenesis, ...
Component extracellular matrix, extracellular region, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (116 records)
Data Summary: Results (111)    Tissues (58)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 77
Northern blot 5
Western blot 5
RT-PCR 14
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mmp13 ; ZFIN mmp13a    NEW 
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(25) Primer pair(7) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000050578 (Evidence)
Entrez Gene 17386 (Evidence)
UniGene 5022
DFCI TC1577492
DoTS DT.40176878
NIA Mouse Gene Index U052600
EC 3.4.24.7, 3.4.24.-
PDB 1CXV
Consensus CDS Project CCDS22803.1
International Mouse Phenotyping Consortium Status Mmp13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17386 NCBI Gene Model | MGI Sequence Detail 10820 C57BL/6J ±  kb
transcript NM_008607 RefSeq | MGI Sequence Detail 2675 C57BL/6 
polypeptide P33435 UniProt | EBI | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028711 Collagenase 3
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, stromelysin-type
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010473 collagenase 3
Graphical View of Protein Domain Structure
References
(Earliest) J:2506 Henriet P, et al., Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases. FEBS Lett. 1992 Sep 28;310(2):175-8
(Latest) J:221866 Yoshida M, et al., The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun. 2015;6:6653
All references(188)
Other
accession IDs
MGD-MRK-12276, MGD-MRK-2012, MGI:97006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory