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Mmp13
Gene Detail
 Symbol
Name
ID
Mmp13
matrix metallopeptidase 13
MGI:1340026
Synonyms Clg, collagenase-1, Collagenase-3, interstitial collagenase, Mmp1, MMP-13
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7272514-7283333 bp, + strand
From NCBI annotation of GRCm38

  10820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp13

Human
homologs
Human Homolog MMP13, matrix metallopeptidase 13 (collagenase 3)
NCBI Gene ID 4322
neXtProt AC  NX_P45452
Human Synonyms  CLG3, MANDP1, MMP-13
Human Chr (Location)  11q22.3; chr11:102942992-102955734 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MMP13
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased width of hypertrophic chondrocyte zone and increased trabecular bone.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process bone mineralization, bone morphogenesis, ...
Component extracellular matrix, extracellular region, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (100 records)
Data Summary: Results (91)    Tissues (53)    Images (27)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 65
Northern blot 5
Western blot 3
RT-PCR 10
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(24) Primer pair(5) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000050578 (Evidence)
Entrez Gene17386 (Evidence)
UniGene5022
DFCITC1577492
DoTSDT.40176878
NIA Mouse Gene IndexU052600
EC3.4.24.-, 3.4.24.7
PDB1CXV
Consensus CDS ProjectCCDS22803.1
International Mouse Knockout Project StatusMmp13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17386 NCBI Gene Model | MGI Sequence Detail 10820 C57BL/6J ±  kb
transcript NM_008607 RefSeq | MGI Sequence Detail 2675 C57BL/6 
polypeptide P33435 UniProt | EBI | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010473 collagenase 3
Graphical View of Protein Domain Structure
References (Earliest) J:2506 Henriet P, et al., Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases. FEBS Lett. 1992 Sep 28;310(2):175-8
(Latest) J:207562 Nkyimbeng T, et al., Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis. PLoS One. 2013;8(9):e73279
All references(169)
Other
accession IDs
MGD-MRK-12276, MGD-MRK-2012, MGI:97006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory