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Mmp13 Gene Detail
Summary
  • Symbol
    Mmp13
  • Name
    matrix metallopeptidase 13
  • Synonyms
    Clg, collagenase-1, Collagenase-3, interstitial collagenase, Mmp1, MMP-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340026
    NCBI Gene: 17386
  • Gene Overview
    MyGene.info: MMP13
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7272514-7283331 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1-A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340026
protein coding gene Chr9:7272514-7283333 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034319
protein coding gene Chr9:4129448-4140267 (+)
A/J MGP_AJ_G0034296
protein coding gene Chr9:4215918-4226737 (+)
AKR/J MGP_AKRJ_G0034226
protein coding gene Chr9:4089716-4100539 (+)
BALB/cJ MGP_BALBcJ_G0034290
protein coding gene Chr9:3975291-3986110 (+)
C3H/HeJ MGP_C3HHeJ_G0034002
protein coding gene Chr9:4306918-4317737 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034812
protein coding gene Chr9:4286008-4296827 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031750
protein coding gene Chr9:3538535-3549643 (+)
CAST/EiJ MGP_CASTEiJ_G0033329
protein coding gene Chr9:4307283-4318174 (+)
CBA/J MGP_CBAJ_G0033974
protein coding gene Chr9:4390594-4401413 (+)
DBA/2J MGP_DBA2J_G0034131
protein coding gene Chr9:4102637-4113456 (+)
FVB/NJ MGP_FVBNJ_G0034076
protein coding gene Chr9:3899320-3910139 (+)
LP/J MGP_LPJ_G0034218
protein coding gene Chr9:4183734-4194557 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034120
protein coding gene Chr9:5108640-5119459 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034831
protein coding gene Chr9:4086587-4097406 (+)
PWK/PhJ MGP_PWKPhJ_G0033033
protein coding gene Chr9:4261827-4272858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032870
protein coding gene Chr9:4359809-4370728 (+)
WSB/EiJ MGP_WSBEiJ_G0033445
protein coding gene Chr9:4095517-4106340 (+)



Homology
more
  • Human Ortholog
    MMP13, matrix metallopeptidase 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MMP13, matrix metallopeptidase 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLG3, MANDP1, MDST, MMP-13
  • Links
    NCBI Gene ID: 4322
    neXtProt AC: NX_P45452
    UniProt: P45452

  • Chr Location
    11q22.2; chr11:102942992-102955734 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MMP13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased width of hypertrophic chondrocyte zone and increased trabecular bone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050578 Ensembl Gene Model | MGI Sequence Detail 10818 C57BL/6J ±  kb
    transcript ENSMUST00000015394 Ensembl | MGI Sequence Detail 2673 Not Applicable  
    polypeptide ENSMUSP00000015394 Ensembl | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 26
      Primer pair 7
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12276, MGD-MRK-2012, MGI:97006
    References
    more
    • Summaries
      All 269
      Developmental Gene Expression 152
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:2506 Henriet P, et al., Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases. FEBS Lett. 1992 Sep 28;310(2):175-8
    • Latest
      J:264609 Li J, et al., Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory