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Hivep2
Gene Detail
 Symbol
Name
ID
Hivep2
human immunodeficiency virus type I enhancer binding protein 2
MGI:1338076
Synonyms MIBP1, Schnurri-2, Shn-2
Feature Type protein coding gene
Genetic Map
Chromosome 10
5.14 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:13966075-14151374 bp, + strand
From VEGA annotation of GRCm38

  185300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4900  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hivep2

Human
homologs
Human Homolog HIVEP2, human immunodeficiency virus type I enhancer binding protein 2
NCBI Gene ID 3097
neXtProt AC  NX_P31629
Human Synonyms  HIV-EP2, MBP-2, MIBP1, SHN2, ZAS2, ZNF40B
Human Chr (Location)  6q23-q24; chr6:142751467-142946358 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display abnormal thymus anatomy, severely defective positive selection of CD4+ and CD8+ cells, and enhanced T-helper 2 cell differentiation.
 
Interactions
Hivep2 interacts with 415 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process regulation of transcription, DNA-templated, signal transduction, ...
Component nucleus, transcription factor complex
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (122)    Tissues (77)    Images (26)
Theiler Stages: 15, 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 122
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000046529 (Evidence)
Ensembl Gene ModelENSMUSG00000015501 (Evidence)
Entrez Gene15273 (Evidence)
DFCITC1582525, TC1605550, TC1606049
DoTSDT.110615241, DT.110615263, DT.486962, DT.91312292, DT.91379897, DT.91561657, DT.94217243
Consensus CDS ProjectCCDS23704.1
International Mouse Knockout Project StatusHivep2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046529 VEGA Gene Model | MGI Sequence Detail 185300 C57BL/6J ±  kb
transcript OTTMUST00000121048 VEGA | MGI Sequence Detail 9268 Not Applicable 
polypeptide OTTMUSP00000066834 VEGA | MGI Sequence Detail 2430 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(18) UniProt(2)
Polymorphisms SNPs within 2kb(1953 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008605 transcription factor HIVEP2
References (Earliest) J:54634 Dorflinger U, et al., Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Mol Cell Biol. 1999 May;19(5):3736-47
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory