About   Help   FAQ
Targeted Allele Detail
Symbol: Hivep2tm1Sis
Name: human immunodeficiency virus type I enhancer binding protein 2; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:2182914
Synonyms: Shn-2-
Gene: Hivep2  Location: Chr10:13841819-14027118 bp, + strand  Genetic Position: Chr10, 5.14 cM, cytoband A2
Alliance: Hivep2tm1Sis page
Germline Transmission:  Earliest citation of germline transmission: J:72249
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 0.9 kb region of the gene encoding amino acids 1-1713 and containing the N-terminal zinc finger cluster was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of T cells from homozygous mutant animals using monoclonal antibodies directed against amino acids 2287-2500 did not detect protein expression. (J:72249)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hivep2 Mutation:  108 strains or lines available
Original:  J:72249 Takagi T, et al., Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol. 2001 Nov;2(11):1048-53
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory