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Phenotypes Associated with This Genotype
Genotype
MGI:6189180
Allelic
Composition
Hivep2tm1Sis/Hivep2tm1Sis
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep2tm1Sis mutation (2 available); any Hivep2 mutation (108 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show increased locomotor activity in the home cage without clear infradian oscillation

nervous system
• mice exhibit decreased expression levels of synaptic proteins in the dentate gyrus
• the granule cell layer of the dentate gyrus shows a decrease in cell body size, a decrease in nuclear volume in granule cells and an increase in neuronal density
• granule cell dendritic spine diameter and spine neck diameter are lower
• however, spine volume and postsynaptic density area are normal
• granule cell dendritic spine length is increased mainly due to an increase in spine neck length
• mice exhibit thin dendrites with long and thin spines in granule cells in the middle molecular layer of the dorsal dentate gyrus indicating immature dendritic spine morphology
• dendrite diameter of granule cells is decreased
• filamentous mitochondria are seen in the dendritic shaft and the number of constricted mitochondria is decreased while number of elongated mitochondria is normal suggesting that the balance between mitochondrial fusion and fission is compromised
• however, no differences in mitochondria volume, length or number per 1 um of dendritic shaft are seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:271912
schizophrenia DOID:5419 OMIM:181500
J:271912


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory