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Gdf11 Gene Detail
Summary
  • Symbol
    Gdf11
  • Name
    growth differentiation factor 11
  • Synonyms
    Bmp11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338027
    NCBI Gene: 14561
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
  • Regulated by
    Rr476 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr10:128718164-128727587 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.18 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338027
 protein coding gene Chr10:128716393-128727587 (-)
129S1/SvImJ ENSMUSG00200012490
 protein coding gene Chr10:125076297-125085707 (-)
A/J ENSMUSG00195014210
 protein coding gene Chr10:125539596-125549022 (-)
AKR/J ENSMUSG00220005313
 protein coding gene Chr10:125144510-125153931 (-)
BALB/cJ ENSMUSG00180009318
 protein coding gene Chr10:125530573-125539997 (-)
C3H/HeJ ENSMUSG00175005583
 protein coding gene Chr10:125529730-125539150 (-)
C57BL/6NJ ENSMUSG00215011309
 protein coding gene Chr10:125136690-125146115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015959
 protein coding gene Chr10:121248717-121258076 (-)
CAST/EiJ ENSTCUG00005040521
 protein coding gene Chr10:124521362-124530844 (-)
CBA/J ENSMUSG00210007779
 protein coding gene Chr10:125353949-125363373 (-)
DBA/2J ENSMUSG00185025056
 protein coding gene Chr10:125503740-125513161 (-)
FVB/NJ ENSMUSG00205015471
 protein coding gene Chr10:124745173-124754594 (-)
JF1/MsJ ENSUMUG00000038090
 protein coding gene Chr10:126811490-126820908 (-)
LP/J ENSMUSG00230032130
 protein coding gene Chr10:127429300-127438719 (-)
NOD/ShiLtJ ENSMUSG00190014914
 protein coding gene Chr10:125567369-125576794 (-)
NZO/HlLtJ ENSMUSG00225036704
 protein coding gene Chr10:131628308-131637733 (-)
PWK/PhJ ENSLUMG00010009792
 protein coding gene Chr10:125269730-125279148 (-)
SPRET/EiJ ENSMSPG00010030494
 protein coding gene Chr10:127226887-127236307 (-)
WSB/EiJ ENSIUOG00005008623
 protein coding gene Chr10:125150877-125160363 (-)



Homology
more
  • Human Ortholog
    GDF11, growth differentiation factor 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF11, growth differentiation factor 11
  • Synonyms
    BMP-11, BMP11, VHO
  • Links
    NCBI Gene ID: 10220
    UniProt: O95390

  • Chr Location
    12q13.2; chr12:55743122-55757264 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GDF11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 6 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    3 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die neonatally showing altered patterning of the axial skeleton including abnormal trunk-to-tail transition and ectopic ventral mass with impaired renal, palate, stomach, spleen and pancreatic development. A second null allele alters retinal and olfactory epithelium neurogenesis. A third null allele causes extra thoracic vertebrae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    134
  • cDNA Data
    8
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025352 Ensembl Gene Model | MGI Sequence Detail 9424 C57BL/6J ±  kb
    transcript ENSMUST00000026408 Ensembl | MGI Sequence Detail 4062 Not Applicable  
    polypeptide ENSMUSP00000026408 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007919 growth/differentiation factor 11
      (term hierarchy)
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR015616 Growth/differentiation factor 8, C-terminal domain
      IPR001111 TGF-beta, propeptide
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-like
    • GlyGen
      Q9Z1W4 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 8
      Primer pair 8
      Other 5
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 45
      Gene Ontology 16
      Phenotypes 45
    • Earliest
      J:53507 Nakashima M, et al., Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis. Mech Dev. 1999 Feb;80(2):185-9
    • Latest
      J:374790 Chen CY, et al., The distinct roles of TGF-beta signaling in retinal development. iScience. 2025 Nov 21;28(11):113737
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory