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Rps7 Gene Detail
Summary
  • Symbol
    Rps7
  • Name
    ribosomal protein S7
  • Synonyms
    Mtu, S7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333818
    NCBI Gene: 20115
  • Gene Overview
    MyGene.info: RPS7
Location & Maps
more
  • Sequence Map
    Chr12:28630847-28635953 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5107 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 10.99 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RPS7, ribosomal protein S7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RPS7, ribosomal protein S7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBA8, S7
  • Links
    NCBI Gene ID: 6201
    neXtProt AC: NX_P62081

  • Chr Location
    2p25; chr2:3575263-3580919 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RPS7 associations

Human Disease Mouse Models
       Diamond-Blackfan Anemia 8; DBA8   OMIM: 612563
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    2
  • Gene trapped
    13
  • Targeted
    2
  • Incidental Mutations
Mice heterozygous for this ENU-induced mutation exhibit a white ventral patch and an extremely kinked or looped tail. Homozygotes exhibit an open hindbrain and defective neural crest production at E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20115 NCBI Gene Model | MGI Sequence Detail 5107 C57BL/6J ±  kb
transcript NM_011300 RefSeq | MGI Sequence Detail 961 C57BL/6  
polypeptide P62082 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    135 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000554 Ribosomal protein S7e
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
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MGI:3043038
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:51004 Annilo T, et al., Isolation and characterization of the mouse ribosomal protein S7 gene. Biochem Mol Biol Int. 1998 Oct;46(2):287-95
  • Latest
    J:195156 Watkins-Chow DE, et al., Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet. 2013 Jan;9(1):e1003094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory