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Dnase2a
Gene Detail
 Symbol
Name
ID
Dnase2a
deoxyribonuclease II alpha
MGI:1329019
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:84908560-84922915 bp, + strand
From VEGA annotation of GRCm38

  14356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: deoxyribonuclease II
Gene Tree: Dnase2a

Human
homologs
Human Homolog DNASE2, deoxyribonuclease II, lysosomal
NCBI Gene ID 1777
neXtProt AC  NX_O00115
Human Synonyms  DNASE2A, DNL, DNL2
Human Chr (Location)  19p13.2; chr19:12875211-12881521 (-)  GRCh38
Alleles
and
phenotypes
All alleles(89) : Targeted(4) Gene trapped(85)
 
Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis.
 
Human Diseases Modeled Using Mouse Dnase2a (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic DNA fragmentation, apoptotic process, ...
Component intracellular, lysosome
Function deoxyribonuclease II activity, endodeoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (2)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 25
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022266 (Evidence)
Ensembl Gene ModelENSMUSG00000003812 (Evidence)
Entrez Gene13423 (Evidence)
DFCITC1581953, TC1626729, TC1721648
NIA Mouse Gene IndexU159636
EC3.1.22.1
Consensus CDS ProjectCCDS22484.1
International Mouse Knockout Project StatusDnase2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022266 VEGA Gene Model | MGI Sequence Detail 14356 C57BL/6J ±  kb
transcript OTTMUST00000053020 VEGA | MGI Sequence Detail 1715 Not Applicable 
polypeptide OTTMUSP00000025187 VEGA | MGI Sequence Detail 353 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004947 Deoxyribonuclease II
Protein Ontology PR:000006596 deoxyribonuclease-2-alpha
References (Earliest) J:49551 Baker KP, et al., Molecular cloning and characterization of human and murine DNase II. Gene. 1998 Jul 30;215(2):281-9
(Latest) J:199384 Ohkouchi S, et al., Biogenesis and proteolytic processing of lysosomal DNase II. PLoS One. 2013;8(3):e59148
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory