Dnase2a
Gene Detail

Symbol Name ID

Dnase2a deoxyribonuclease II alpha MGI:1329019

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:84908560-84922915 bp, + strand From VEGA annotation of GRCm38   14356 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: deoxyribonuclease II
Gene Tree: Dnase2a

Human homologs

Human Homolog		DNASE2, deoxyribonuclease II, lysosomal
NCBI Gene ID		1777
neXtProt AC		NX_O00115
Human Synonyms		DNASE2A, DNL, DNL2
Human Chr (Location)		19p13.2; chr19:12986025-12992335 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(89) : Targeted(4) Gene trapped(85)
 

Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis.

 
Human Diseases Modeled Using Mouse Dnase2a (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	apoptotic process, DNA catabolic process, ...
Component	lysosome
Function	deoxyribonuclease II activity, endodeoxyribonuclease activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (2)    Images (21)
Theiler Stages: 23

Assay Type	Results
RNA in situ	25

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022266 (Evidence)
Ensembl Gene Model	ENSMUSG00000003812 (Evidence)
Entrez Gene	13423 (Evidence)
DFCI	TC1581953, TC1626729, TC1721648
NIA Mouse Gene Index	U159636
EC	3.1.22.1
Consensus CDS Project	CCDS22484.1
International Mouse Knockout Project Status	Dnase2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022266	VEGA Gene Model | MGI Sequence Detail	14356	C57BL/6J
transcript	OTTMUST00000053020	VEGA | MGI Sequence Detail	1715	Not Applicable
polypeptide	OTTMUSP00000025187	VEGA | MGI Sequence Detail	353	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004947	Deoxyribonuclease II
Protein Ontology	PR:000006596	deoxyribonuclease-2-alpha

References

(Earliest) J:49551 Baker KP, et al., Molecular cloning and characterization of human and murine DNase II. Gene. 1998 Jul 30;215(2):281-9
(Latest) J:192255 Ahn J, et al., STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19386-91
All references(45)