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Dnase2a Gene Detail
Summary
  • Symbol
    Dnase2a
  • Name
    deoxyribonuclease II alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329019
    NCBI Gene: 13423
Location & Maps
more
  • Sequence Map
    Chr8:84908560-84922915 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14356 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.31 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNASE2, deoxyribonuclease 2, lysosomal
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DNASE2, deoxyribonuclease 2, lysosomal
    Orthology source: HomoloGene
  • Synonyms
    DNASE2A, DNL, DNL2
  • Links
    NCBI Gene ID: 1777
    neXtProt AC: NX_O00115

  • Chr Location
    19p13.2; chr19:12875211-12881521 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dnase2a mouse models

Human Disease Mouse Models
       Rheumatoid Arthritis; RA   OMIM: 180300 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Dnase2a
  • Incidental Mutations
Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022266 VEGA Gene Model | MGI Sequence Detail 14356 C57BL/6J ±  kb
transcript OTTMUST00000053020 VEGA | MGI Sequence Detail 1715 Not Applicable  
polypeptide OTTMUSP00000025187 VEGA | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 8
    Phenotypes 49
  • Earliest
    J:49551 Baker KP, et al., Molecular cloning and characterization of human and murine DNase II. Gene. 1998 Jul 30;215(2):281-9
  • Latest
    J:226998 Gao D, et al., Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory