About   Help   FAQ
Dnase2a
Gene Detail
Symbol

Name
ID
Dnase2a
deoxyribonuclease II alpha
MGI:1329019
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:84908560-84922915 bp, + strand
From VEGA annotation of GRCm38

  14356 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DNASE2
Protein SuperFamily: deoxyribonuclease II
Gene Tree: Dnase2a

Human
homologs
DNASE2, deoxyribonuclease II, lysosomal
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1777
neXtProt AC: NX_O00115

Human Synonyms: DNASE2A, DNL, DNL2

Human Chr (Location): 19p13.2; chr19:12875211-12881521 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis.
 
Human Diseases Modeled in Mice Using Dnase2a (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Dnase2a interacts with 87 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic DNA fragmentation, apoptotic process, ...
Component extracellular exosome, lysosome
Function deoxyribonuclease II activity, endodeoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (2)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022266 (Evidence)
Ensembl Gene Model ENSMUSG00000003812 (Evidence)
Entrez Gene 13423 (Evidence)
DFCI TC1721648, TC1626729, TC1581953
NIA Mouse Gene Index U159636
EC 3.1.22.1
Consensus CDS Project CCDS22484.1
International Mouse Phenotyping Consortium Status Dnase2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022266 VEGA Gene Model | MGI Sequence Detail 14356 C57BL/6J ±  kb
transcript OTTMUST00000053020 VEGA | MGI Sequence Detail 1715 Not Applicable 
polypeptide OTTMUSP00000025187 VEGA | MGI Sequence Detail 353 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004947 Deoxyribonuclease II
Protein Ontology PR:000006596 deoxyribonuclease-2-alpha
References
(Earliest) J:49551 Baker KP, et al., Molecular cloning and characterization of human and murine DNase II. Gene. 1998 Jul 30;215(2):281-9
(Latest) J:218543 Lan YY, et al., Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Rep. 2014 Oct 9;9(1):180-92
All references(46)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory