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Dnase2a Gene Detail
Summary
  • Symbol
    Dnase2a
  • Name
    deoxyribonuclease II alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329019
    NCBI Gene: 13423
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84908624-84911461 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329019
protein coding gene Chr8:84908560-84922915 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033879
protein coding gene Chr8:85838343-85852657 (+)
A/J MGP_AJ_G0033862
protein coding gene Chr8:82455243-82469555 (+)
AKR/J MGP_AKRJ_G0033788
protein coding gene Chr8:84897953-84912267 (+)
BALB/cJ MGP_BALBcJ_G0033855
protein coding gene Chr8:82582084-82596398 (+)
C3H/HeJ MGP_C3HHeJ_G0033565
protein coding gene Chr8:85522054-85536366 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034375
protein coding gene Chr8:89117967-89135462 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031316
protein coding gene Chr8:76247950-76253845 (+)
CAST/EiJ MGP_CASTEiJ_G0032895
protein coding gene Chr8:84953129-84967405 (+)
CBA/J MGP_CBAJ_G0033541
protein coding gene Chr8:92155668-92169980 (+)
DBA/2J MGP_DBA2J_G0033694
protein coding gene Chr8:82094647-82108959 (+)
FVB/NJ MGP_FVBNJ_G0033642
protein coding gene Chr8:81039122-81057037 (+)
LP/J MGP_LPJ_G0033786
protein coding gene Chr8:85946432-85960744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033684
protein coding gene Chr8:94714941-94729892 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034392
protein coding gene Chr8:84888241-84902536 (+)
PWK/PhJ MGP_PWKPhJ_G0032599
protein coding gene Chr8:81340491-81354959 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032435
protein coding gene Chr8:83698276-83712524 (+)
WSB/EiJ MGP_WSBEiJ_G0033008
protein coding gene Chr8:85318841-85333155 (+)



Homology
more
  • Human Ortholog
    DNASE2, deoxyribonuclease 2, lysosomal
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DNASE2, deoxyribonuclease 2, lysosomal
    Orthology source: HomoloGene
  • Synonyms
    DNASE2A, DNL, DNL2
  • Links
    NCBI Gene ID: 1777
    neXtProt AC: NX_O00115
    UniProt: O00115

  • Chr Location
    19p13.13; chr19:12875211-12881521 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dnase2a mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13423 NCBI Gene Model | MGI Sequence Detail 2838 C57BL/6J ±  kb
    transcript NM_010062 RefSeq | MGI Sequence Detail 1643 Not Specified  
    polypeptide P56542 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 9
      Phenotypes 56
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory