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Trex1
Gene Detail
Symbol

Name
ID
Trex1
three prime repair exonuclease 1
MGI:1328317
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:109057932-109059723 bp, - strand
From NCBI annotation of GRCm38

  1792 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TREX1
Gene Tree: Trex1

Human
homologs
TREX1, three prime repair exonuclease 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11277
neXtProt AC: NX_Q9NSU2

Human Synonyms: AGS1, CRV, DRN3, HERNS

Human Chr (Location): 3p21.31; chr3:48465520-48467645 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human TREX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Homozygous null mice display a decreased life span, cardiomyopathy, myocarditis, atrial thrombosis, and abnormal spleen morphology.
 
Human Diseases Modeled in Mice Using Trex1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trex1 interacts with 13 markers (Mir18b, Mir31, Mir125a, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000049734 (Evidence)
Entrez Gene 22040 (Evidence)
EC 3.1.11.2
PDB 2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F, 4YNQ
Consensus CDS Project CCDS23544.1
International Mouse Phenotyping Consortium Status Trex1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22040 NCBI Gene Model | MGI Sequence Detail 1792 C57BL/6J ±  kb
transcript NM_011637 RefSeq | MGI Sequence Detail 1074 C57BL/6 
polypeptide Q91XB0 UniProt | EBI | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000016632 three prime repair exonuclease 1
Graphical View of Protein Domain Structure
References
(Earliest) J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
(Latest) J:209981 Zang Y, et al., Conservation of pathogenic TCR homology across class II restrictions in anti-ribonucleoprotein autoimmunity: extended efficacy of T cell vaccine therapy. J Immunol. 2014 May 1;192(9):4093-102
All references(50)
Disease annotation references (2)
Other
accession IDs
MGI:2143232

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory