Trex1
Gene Detail

Symbol Name ID

Trex1 three prime repair exonuclease 1 MGI:1328317

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:109057933-109060338 bp, - strand From VEGA annotation of GRCm38   2406 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trex1 ± 2 cM)

Gene Tree: Trex1

Human ortholog

TREX1 three prime repair exonuclease 1 NCBI Gene ID 11277
Human Synonyms: AGS1, CRV, DRN3, HERNS
Human Chr3:48507229-48509044 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human TREX1 (4)

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous null mice display a decreased life span, cardiomyopathy, myocarditis, atrial thrombosis, and abnormal spleen morphology.

 
Human Diseases Modeled Using Mouse Trex1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cellular response to interferon-beta, DNA repair, ...
Component	intracellular, nucleus
Function	3'-5' exonuclease activity, adenyl deoxyribonucleotide binding, ...

External Resources: FuncBase

Expression

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020568 (Evidence)
Ensembl Gene Model	ENSMUSG00000049734 (Evidence)
Entrez Gene	22040 (Evidence)
EC	3.1.11.2
PDB	2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F
Consensus CDS Project	CCDS23544.1
International Mouse Knockout Project Status	Trex1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020568	VEGA Gene Model | MGI Sequence Detail	2406	C57BL/6J
transcript	OTTMUST00000048744	VEGA | MGI Sequence Detail	1054	Not Applicable
polypeptide	OTTMUSP00000022433	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(37) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006055	Exonuclease
InterPro	IPR012337	Ribonuclease H-like domain
Protein Ontology	PR:000016632	three prime repair exonuclease 1

References

(Earliest) J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
(Latest) J:191073 Hasan M, et al., Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol. 2013 Jan;14(1):61-71
All references(45)

Other accession IDs

MGI:2143232