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Trex1 Gene Detail
Summary
  • Symbol
    Trex1
  • Name
    three prime repair exonuclease 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328317
    NCBI Gene: 22040
  • Gene Overview
    MyGene.info: TREX1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:109057932-109059723 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328317
protein coding gene Chr9:109057932-109059734 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035323
protein coding gene Chr9:111014749-111016550 (-)
A/J MGP_AJ_G0035302
protein coding gene Chr9:106931037-106932838 (-)
AKR/J MGP_AKRJ_G0035234
protein coding gene Chr9:109624554-109626355 (-)
BALB/cJ MGP_BALBcJ_G0035296
protein coding gene Chr9:106631142-106632943 (-)
C3H/HeJ MGP_C3HHeJ_G0035006
protein coding gene Chr9:110014225-110016026 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035816
protein coding gene Chr9:114041291-114043092 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032714
protein coding gene Chr9:104337546-104339327 (-)
CAST/EiJ MGP_CASTEiJ_G0034317
protein coding gene Chr9:109987833-109989639 (-)
CBA/J MGP_CBAJ_G0034974
protein coding gene Chr9:118054192-118055993 (-)
DBA/2J MGP_DBA2J_G0035135
protein coding gene Chr9:106386264-106388065 (-)
FVB/NJ MGP_FVBNJ_G0035083
protein coding gene Chr9:105206235-105208036 (-)
LP/J MGP_LPJ_G0035211
protein coding gene Chr9:111200406-111202207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035122
protein coding gene Chr9:119608222-119610023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035837
protein coding gene Chr9:109893988-109895789 (-)
PWK/PhJ MGP_PWKPhJ_G0034024
protein coding gene Chr9:106722769-106724654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033859
protein coding gene Chr9:109959093-109960902 (-)
WSB/EiJ MGP_WSBEiJ_G0034438
protein coding gene Chr9:109791339-109793140 (-)



Homology
more
  • Human Ortholog
    TREX1, three prime repair exonuclease 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TREX1, three prime repair exonuclease 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGS1, CRV, DRN3, HERNS
  • Links
    NCBI Gene ID: 11277
    neXtProt AC: NX_Q9NSU2
    UniProt: Q9NSU2

  • Chr Location
    3p21.31; chr3:48465520-48467645 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Trex1 mouse models; 3 with human TREX1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 2 alleles in 5 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice display premature death, cardiomyopathy, myocarditis, atrial thrombosis, and altered spleen morphology. Homozygotes for the D18N allele develop lupus-like disease with systemic inflammation, lymphoid hyperplasia, vasculitis, production of autoantibodies to dsDNA, and renal disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22040 NCBI Gene Model | MGI Sequence Detail 1792 C57BL/6J ±  kb
transcript NM_011637 RefSeq | MGI Sequence Detail 1074 C57BL/6  
polypeptide Q91XB0 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143232
References
more
  • Summaries
    All 70
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 28
    Phenotypes 29
  • Earliest
    J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
  • Latest
    J:261862 Ahn J, et al., Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells. Cancer Cell. 2018 May 14;33(5):862-873.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory