Symbol
Name
ID

Trex1
three prime repair exonuclease 1
MGI:1328317

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Increased circulating antibody level

Elevated circulating creatinine concentration

Increased circulating ferritin concentration

Increased CSF interferon alpha

Elevated circulating hepatic transaminase concentration

Elevated gamma-glutamyltransferase level

Elevated circulating alkaline phosphatase concentration

Elevated erythrocyte sedimentation rate

Diabetes mellitus

Edema

Macular edema

Fever

Unexplained fevers

Hepatic steatosis

Hematuria

Pyuria

Proteinuria

Calcification of the aorta

Cerebellar calcifications

Cerebral calcification

Basal ganglia calcification

Intracerebral periventricular calcifications

Disease(s) Associated with TREX1

Aicardi-Goutieres syndrome

Chilblain lupus

retinal vasculopathy with cerebral leukodystrophy

systemic lupus erythematosus

Mouse Phenotypes		increased circulating tumor necrosis factor level	abnormal atrial thrombosis
Availability	Mouse Genotype	increased circulating tumor necrosis factor level	abnormal atrial thrombosis
	Trex1^em3Gpt/Trex1^em3Gpt
	Trex1^tm1.1Fwpe/Trex1^tm1.1Fwpe
	Trex1^tm1Tld/Trex1^tm1Tld

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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