Phenotypes Associated with This Genotype

Genotype
MGI:5925413

• Allelic Composition: Trex1^tm1Tld/Trex1^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to autoimmune disorder ( J:243357 )

• mice irradiated with UVB develop erythematosquamous cutaneous lupus erythematosus-like skin lesions within days of irradiation

• skin lesions of UVB-irradiated mice have an interface dermatitis including basal hydropic degeneration of the epidermis and colloid bodies, extensive infiltration of CD45+ immune cells, and expression of cutaneous lupus erythematosus-typical chemokines (CXCL10 and MxA)

dermatitis ( J:243357 )

• UVB-irradiated mice exhibit interface dermatitis

integument

dermatitis ( J:243357 )

• UVB-irradiated mice exhibit interface dermatitis

skin lesions ( J:243357 )

• mice irradiated with UVB develop erythematosquamous cutaneous lupus erythematosus-like skin lesions within days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cutaneous lupus erythematosus		DOID:0050169		J:243357