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Slit2 Gene Detail
Summary
  • Symbol
    Slit2
  • Name
    slit guidance ligand 2
  • Synonyms
    b2b1200.1Clo, Drad-1, E030015M03Rik, E130320P19Rik, Slil3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315205
    NCBI Gene: 20563
  • Gene Overview
    MyGene.info: SLIT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:47983138-48307733 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      324596 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 26.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLIT2, slit guidance ligand 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLIT2, slit guidance ligand 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLIL3, Slit-2
  • Links
    NCBI Gene ID: 9353
    neXtProt AC: NX_O94813
    UniProt: O94813

  • Chr Location
    4p15.31; chr4:20251905-20620561 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Slit2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    23 images
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037422 VEGA Gene Model | MGI Sequence Detail 324596 C57BL/6J ±  kb
    transcript OTTMUST00000096562 VEGA | MGI Sequence Detail 7785 Not Applicable  
    polypeptide OTTMUSP00000053964 VEGA | MGI Sequence Detail 1542 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2202 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR006207 Cystine knot, C-terminal
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR003645 Follistatin-like, N-terminal
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 101
      Primer pair 4
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1333781, MGI:2442301, MGI:2443562, MGI:5437089
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 122
      Diseases 2
      Gene Ontology 21
      Phenotypes 72
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:253971 Dominici C, et al., Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins. Development. 2018 Jan 17;145(2):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory