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Gene Detail
slit homolog 2 (Drosophila)
Synonyms Drad-1, E030015M03Rik, E130320P19Rik, Slil3
Feature Type protein coding gene
Genetic Map
Chromosome 5
26.05 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
Chr5:47983155-48306282 bp, + strand
From VEGA annotation of GRCm38

  323128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:3516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: slit protein
Gene Tree: Slit2

Human Homolog SLIT2, slit homolog 2 (Drosophila)
NCBI Gene ID 9353
neXtProt AC  NX_O94813
Human Synonyms  SLIL3, Slit-2
Human Chr (Location)  4p15.2; chr4:20252943-20620561 (+)  GRCh38
alleles, and
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Slit2 (1)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.
Alleles Annotated to Human Diseases(1)   
Slit2 interacts with 232 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
All GO classifications: (82 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component cell surface, cytoplasm, ...
Function calcium ion binding, chemorepellent activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (90 records)
Data Summary: Results (474)    Tissues (375)    Images (111)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 18
RNA in situ 445
Northern blot 9
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(106) cDNA(100) Primer pair(2) Other(4)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000037422 (Evidence)
Ensembl Gene ModelENSMUSG00000031558 (Evidence)
Entrez Gene20563 (Evidence)
DFCITC1577558, TC1583592, TC1593405, TC1593429, TC1595474, TC1604783, TC1613391, TC1616897, TC1619741, TC1632865, TC1711573
DoTSDT.101129636, DT.101296003, DT.103575521, DT.484030, DT.91305278, DT.91319210, DT.91331527, DT.91410444, DT.91587238, DT.94165478
NIA Mouse Gene IndexU005564
Consensus CDS ProjectCCDS19280.1, CCDS71586.1, CCDS71588.1
International Mouse Knockout Project StatusSlit2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037422 VEGA Gene Model | MGI Sequence Detail 323128 C57BL/6J ±  kb
transcript OTTMUST00000096562 VEGA | MGI Sequence Detail 5139 Not Applicable 
polypeptide OTTMUSP00000053964 VEGA | MGI Sequence Detail 1542 Not Applicable 

For the selected sequences
All sequences(134) RefSeq(15) UniProt(13)
Polymorphisms SNPs within 2kb(2208 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2210)
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015235 slit homolog 2 protein
References (Earliest) J:46738 Hassoun H, et al., Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998 Mar 15;91(6):2146-51
(Latest) J:210623 Yeh ML, et al., Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
All references(142)
accession IDs
MGI:1333781, MGI:2442301, MGI:2443562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory