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Slit2
Gene Detail
Symbol

Name
ID
Slit2
slit homolog 2 (Drosophila)
MGI:1315205
Synonyms
Drad-1, E030015M03Rik, E130320P19Rik, Slil3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
26.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:47983155-48306282 bp, + strand
From VEGA annotation of GRCm38

  323128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: slit protein
Gene Tree: Slit2

Human
homologs
Human Homolog SLIT2, slit homolog 2 (Drosophila)
NCBI Gene ID 9353
neXtProt AC  NX_O94813
Human Synonyms  SLIL3, Slit-2
Human Chr (Location)  4p15.2; chr4:20252943-20620561 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Slit2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Slit2 interacts with 232 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component cell surface, cytoplasm, ...
Function calcium ion binding, chemorepellent activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (92 records)
Data Summary: Results (474)    Tissues (375)    Images (111)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 445
Northern blot 9
RT-PCR 2
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) cDNA(100) Primer pair(2) Other(4)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037422 VEGA Gene Model | MGI Sequence Detail 323128 C57BL/6J ±  kb
transcript OTTMUST00000096562 VEGA | MGI Sequence Detail 5139 Not Applicable 
polypeptide OTTMUSP00000053964 VEGA | MGI Sequence Detail 1542 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(15) UniProt(25)
Polymorphisms
SNPs within 2kb(2208 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2210)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015235 slit homolog 2 protein
References
(Earliest) J:46738 Hassoun H, et al., Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998 Mar 15;91(6):2146-51
(Latest) J:210623 Yeh ML, et al., Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
All references(144)
Other
accession IDs
MGI:1333781, MGI:2442301, MGI:2443562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory