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Slit2 Gene Detail
Summary
  • Symbol
    Slit2
  • Name
    slit homolog 2 (Drosophila)
  • Synonyms
    Drad-1, E030015M03Rik, E130320P19Rik, Slil3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315205
    NCBI Gene: 20563
  • Gene Overview
    MyGene.info: SLIT2
Location & Maps
more
  • Sequence Map
    Chr5:47983138-48307733 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      324596 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 26.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLIT2, slit guidance ligand 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLIT2, slit guidance ligand 2
    Orthology source: HomoloGene
  • Synonyms
    SLIL3, Slit-2
  • Links
    NCBI Gene ID: 9353
    neXtProt AC: NX_O94813

  • Chr Location
    4p15.2; chr4:20251925-20620561 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    5 involving Slit2
  • Incidental Mutations
Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037422 VEGA Gene Model | MGI Sequence Detail 324596 C57BL/6J ±  kb
transcript OTTMUST00000096562 VEGA | MGI Sequence Detail 7785 Not Applicable  
polypeptide OTTMUSP00000053964 VEGA | MGI Sequence Detail 1542 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2202 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 107
    cDNA 101
    Primer pair 2
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGI:1333781, MGI:2442301, MGI:2443562
References
more
  • Summaries
    All 164
    Developmental Gene Expression 108
    Diseases 1
    Gene Ontology 19
    Phenotypes 69
  • Earliest
    J:46738 Hassoun H, et al., Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998 Mar 15;91(6):2146-51
  • Latest
    J:229471 Branchfield K, et al., Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory