Slit2
Gene Detail

Symbol Name ID

Slit2 slit homolog 2 (Drosophila) MGI:1315205

Synonyms

Drad-1, E030015M03Rik, E130320P19Rik, Slil3

Feature Type

protein coding gene

Genetic Map

Chromosome 5

26.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:47983155-48306282 bp, + strand From VEGA annotation of GRCm38   323128 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: slit protein
Gene Tree: Slit2

Human homologs

Human Homolog		SLIT2, slit homolog 2 (Drosophila)
NCBI Gene ID		9353
neXtProt AC		NX_O94813
Human Synonyms		SLIL3, Slit-2
Human Chr (Location)		4p15.2; chr4:20255235-20620788 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.

 

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	axon extension involved in axon guidance, axon guidance, ...
Component	cell surface, cytoplasm, ...
Function	calcium ion binding, chemorepellent activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (86 records)
Data Summary: Results (368)    Tissues (300)    Images (83)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	18
RNA in situ	339
Northern blot	9
RT-PCR	2

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(106) cDNA(101) Primer pair(2) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037422 (Evidence)
Ensembl Gene Model	ENSMUSG00000031558 (Evidence)
Entrez Gene	20563 (Evidence)
UniGene	289739
DFCI	TC1577558, TC1583592, TC1593405, TC1593429, TC1595474, TC1604783, TC1613391, TC1616897, TC1619741, TC1632865, TC1711573
DoTS	DT.101129636, DT.101296003, DT.103575521, DT.484030, DT.91305278, DT.91319210, DT.91331527, DT.91410444, DT.91587238, DT.94165478
NIA Mouse Gene Index	U005564
Consensus CDS Project	CCDS19280.1
International Mouse Knockout Project Status	Slit2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037422	VEGA Gene Model | MGI Sequence Detail	323128	C57BL/6J
transcript	OTTMUST00000096562	VEGA | MGI Sequence Detail	5139	Not Applicable
polypeptide	OTTMUSP00000053964	VEGA | MGI Sequence Detail	1542	Not Applicable

All sequences(121) RefSeq(2) UniProt(13)

Polymorphisms

SNPs(1981 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR003645	Follistatin-like, N-terminal
InterPro	IPR001791	Laminin G domain
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000015235	slit 2 protein

References

(Earliest) J:46738 Hassoun H, et al., Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998 Mar 15;91(6):2146-51
(Latest) J:193400 Domyan ET, et al., Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14;24(1):52-63
All references(133)

Other accession IDs

MGI:1333781, MGI:2442301, MGI:2443562