About   Help   FAQ
Hcn4 Gene Detail
Summary
  • Symbol
    Hcn4
  • Name
    hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298209
    NCBI Gene: 330953
  • Gene Overview
    MyGene.info: HCN4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:58823512-58860955 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37444 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.80 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SSS2
  • Links
    NCBI Gene ID: 10021
    neXtProt AC: NX_Q9Y3Q4
    UniProt: Q9Y3Q4

  • Chr Location
    15q24.1; chr15:73319859-73369264 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human HCN4 associations

Human Disease Mouse Models
      
IDs
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 9 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience embryonic lethality between E9.5 and E11.5. Conditional deletion in cardiac tissue results in severe bradycardia and death. Mice over-expressing the gene exhibit impaired firing rate in ORN, small olfactory bulb and reduced glomeruli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 330953 NCBI Gene Model | MGI Sequence Detail 37444 C57BL/6J ±  kb
    transcript NM_001081192 RefSeq | MGI Sequence Detail 6675 C57BL/6  
    polypeptide O70507 UniProt | EBI | MGI Sequence Detail 1186 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      145 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR005821 Ion transport domain
      IPR013621 Ion transport N-terminal
      IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
      IPR030173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 3
      Other 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 59
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
    • Latest
      J:262277 Baggio LL, et al., The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice. Mol Metab. 2017 Nov;6(11):1339-1349

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory