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Hcn4 Gene Detail
Summary
  • Symbol
    Hcn4
  • Name
    hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298209
    NCBI Gene: 330953
  • Gene Overview
    MyGene.info: HCN4
Location & Maps
more
  • Sequence Map
    Chr9:58823512-58860955 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37444 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SSS2
  • Links
    NCBI Gene ID: 10021
    neXtProt AC: NX_Q9Y3Q4

  • Chr Location
    15q24.1; chr15:73319859-73369264 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human HCN4 associations

Human Disease Mouse Models
       Brugada Syndrome 8; BRGDA8   OMIM: 613123
Sick Sinus Syndrome 2, Autosomal Dominant; SSS2   OMIM: 163800
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 10 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience embryonic lethality between E9.5 and E11.5. Conditional deletion in cardiac tissue results in severe bradycardia and death. Mice over-expressing the gene exhibit impaired firing rate in ORN, small olfactory bulb and reduced glomeruli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 330953 NCBI Gene Model | MGI Sequence Detail 37444 C57BL/6J ±  kb
transcript NM_001081192 RefSeq | MGI Sequence Detail 3798 Not Specified  
polypeptide O70507 UniProt | EBI | MGI Sequence Detail 1186 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    145 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
  • InterPro Domains
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR005821 Ion transport domain
    IPR013621 Ion transport N-terminal
    IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
    IPR030173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 17
    cDNA 11
    Primer pair 3
    Other 3

    Microarray probesets 1
References
more
  • Summaries
    All 85
    Developmental Gene Expression 47
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
  • Latest
    J:226315 Ye W, et al., A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node. Development. 2015 Jul 15;142(14):2521-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory