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Hcn4
Gene Detail
 Symbol
Name
ID
Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
MGI:1298209
Feature Type protein coding gene
Genetic Map
Chromosome 9
31.80 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:58823512-58860955 bp, + strand
From NCBI annotation of GRCm38

  37444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn4

Human
homologs
Human Homolog HCN4, hyperpolarization activated cyclic nucleotide-gated potassium channel 4
NCBI Gene ID 10021
neXtProt AC  NX_Q9Y3Q4
Human Synonyms  SSS2
Human Chr (Location)  15q24.1; chr15:73319859-73369264 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human HCN4
Alleles
and
phenotypes
All alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene experience embryonic lethality between E9.5 and E11.5. Conditional deletion in cardiac tissue results in severe bradycardia and death. Mice over-expressing the gene exhibit impaired firing rate in ORN, small olfactory bulb and reduced glomeruli.
 
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cation transport, cellular response to cAMP, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function cAMP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (19)    Tissues (7)    Images (6)
Theiler Stages: 20, 25, 28
Assay TypeResults
Immunohistochemistry 13
Western blot 2
RT-PCR 4
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000032338 (Evidence)
Entrez Gene330953 (Evidence)
UniGene151967
DFCITC1614078
DoTSDT.55274624
NIA Mouse Gene IndexU010574
Consensus CDS ProjectCCDS52815.1
International Mouse Knockout Project StatusHcn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 330953 NCBI Gene Model | MGI Sequence Detail 37444 C57BL/6J ±  kb
transcript NM_001081192 RefSeq | MGI Sequence Detail 3798 Not Specified 
polypeptide O70507 UniProt | EBI | MGI Sequence Detail 1186 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR013621 Ion transport N-terminal
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Graphical View of Protein Domain Structure
References (Earliest) J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
(Latest) J:207953 Nakashima N, et al., Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice. J Physiol. 2013 Apr 1;591(Pt 7):1749-69
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory