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Hcn4
Gene Detail
Symbol

Name
ID
Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
MGI:1298209
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.80 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:58823512-58860955 bp, + strand
From NCBI annotation of GRCm38

  37444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HCN4
Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn4

Human
homologs
HCN4, hyperpolarization activated cyclic nucleotide gated potassium channel 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10021
neXtProt AC: NX_Q9Y3Q4

Human Synonyms: SSS2

Human Chr (Location): 15q24.1; chr15:73319859-73369264 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HCN4

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene experience embryonic lethality between E9.5 and E11.5. Conditional deletion in cardiac tissue results in severe bradycardia and death. Mice over-expressing the gene exhibit impaired firing rate in ORN, small olfactory bulb and reduced glomeruli.
 
Interactions
Hcn4 interacts with 30 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process cation transmembrane transport, cation transport, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function cAMP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (127)    Tissues (44)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 101
Western blot 2
RT-PCR 9
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498501 ; ZFIN hcn4    NEW 
Molecular
reagents
All nucleic(16) cDNA(11) Primer pair(3) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000032338 (Evidence)
Entrez Gene 330953 (Evidence)
UniGene 151967
DFCI TC1614078
DoTS DT.55274624
NIA Mouse Gene Index U010574
Consensus CDS Project CCDS52815.1
International Mouse Phenotyping Consortium Status Hcn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 330953 NCBI Gene Model | MGI Sequence Detail 37444 C57BL/6J ±  kb
transcript NM_001081192 RefSeq | MGI Sequence Detail 3798 Not Specified 
polypeptide O70507 UniProt | EBI | MGI Sequence Detail 1186 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR013621 Ion transport N-terminal
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR030173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Graphical View of Protein Domain Structure
References
(Earliest) J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
(Latest) J:219365 Simmons O, et al., Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality. Dev Dyn. 2015 Mar;244(3):457-67
All references(83)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory