Hcn4
Gene Detail

Symbol Name ID

Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 MGI:1298209

Feature Type

protein coding gene

Genetic Map

Chromosome 9

31.80 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:58823512-58860955 bp, + strand From NCBI annotation of GRCm38   37444 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken

Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn4

Human homologs

Human Homolog		HCN4, hyperpolarization activated cyclic nucleotide-gated potassium channel 4
NCBI Gene ID		10021
neXtProt AC		NX_Q9Y3Q4
Human Synonyms		SSS2
Human Chr (Location)		15q24.1; chr15:73612200-73661605 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HCN4

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Mice homozygous for disruptions in this gene experience embryonic lethality. Death occurs between E9.5 and E11.5. Conditional deletion in cardiac tissue results in severe bradycardia and death.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cation transport, in utero embryonic development, ...
Component	integral to membrane, membrane, ...
Function	cAMP binding, intracellular cAMP activated cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (6)    Tissues (3)   
Theiler Stages: 25, 28

Assay Type	Results
Western blot	2
RT-PCR	4

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000032338 (Evidence)
Entrez Gene	330953 (Evidence)
UniGene	151967
DFCI	TC1614078
DoTS	DT.55274624
NIA Mouse Gene Index	U010574
Consensus CDS Project	CCDS52815.1
International Mouse Knockout Project Status	Hcn4

Sequences

Length	Strain/Species
genomic	330953	NCBI Gene Model | MGI Sequence Detail	37444	C57BL/6J
transcript	NM_001081192	RefSeq | MGI Sequence Detail	3798	Not Specified
polypeptide	O70507	UniProt | EBI | MGI Sequence Detail	1186	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR013621	Ion transport N-terminal
InterPro	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000708	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Graphical View of Protein Domain Structure

References

(Earliest) J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
(Latest) J:192191 Vedantham V, et al., Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Dev Biol. 2013 Jan 1;373(1):149-62
All references(68)