About   Help   FAQ
Slc7a5
Gene Detail
Symbol

Name
ID
Slc7a5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
MGI:1298205
Synonyms
D0H16S474E, LAT1, TA1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
70.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:121881150-121907694 bp, - strand
From VEGA annotation of GRCm38

  26545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a5

Human
homologs
Human Homolog SLC7A5, solute carrier family 7 (amino acid transporter light chain, L system), member 5
NCBI Gene ID 8140
neXtProt AC  NX_Q01650
Human Synonyms  4F2LC, CD98, D16S469E, E16, hLAT1, LAT1, MPE16
Human Chr (Location)  16q24.3; chr16:87830023-87869494 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation die prenatally.
 
Interactions
Slc7a5 interacts with 214 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (146)    Tissues (53)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 93
RT-PCR 38
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(82) cDNA(78) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043045 (Evidence)
Ensembl Gene ModelENSMUSG00000040010 (Evidence)
Entrez Gene20539 (Evidence)
UniGene27943
DFCITC1592393, TC1575710, TC1748393
DoTSDT.489652, DT.110849004, DT.101222912, DT.110849022
NIA Mouse Gene IndexU030347
Consensus CDS ProjectCCDS22730.1
International Mouse Knockout Project StatusSlc7a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043045 VEGA Gene Model | MGI Sequence Detail 26545 C57BL/6J ±  kb
transcript OTTMUST00000112980 VEGA | MGI Sequence Detail 3517 Not Applicable 
polypeptide OTTMUSP00000063271 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(589 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004760 L-type amino acid transporter
Protein Ontology PR:000015201 large neutral amino acids transporter small subunit 1
References
(Earliest) J:48072 Kimura N, et al., Entactin-2: a new member of basement membrane protein with high homology to entactin/ nidogen. Exp Cell Res. 1998 May 25;241(1):36-45
(Latest) J:201184 Ferrara AM, et al., Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013 Jul;154(7):2533-41
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory