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Slc7a5
Gene Detail
Symbol

Name
ID
Slc7a5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
MGI:1298205
Synonyms
D0H16S474E, LAT1, TA1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
70.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:121881150-121907694 bp, - strand
From VEGA annotation of GRCm38

  26545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC7A5
Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a5

Human
homologs
SLC7A5, solute carrier family 7 (amino acid transporter light chain, L system), member 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8140
neXtProt AC: NX_Q01650

Human Synonyms: 4F2LC, CD98, D16S469E, E16, hLAT1, LAT1, MPE16

Human Chr (Location): 16q24.3; chr16:87830023-87869497 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation die prenatally.
 
Interactions
Slc7a5 interacts with 214 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process amino acid transmembrane transport, amino acid transport, ...
Component cytoplasm, extracellular exosome, ...
Function amino acid transmembrane transporter activity, antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (181)    Tissues (65)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 93
Western blot 15
RT-PCR 58
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc7a5    NEW 
Molecular
reagents
All nucleic(83) cDNA(78) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000043045 (Evidence)
Ensembl Gene Model ENSMUSG00000040010 (Evidence)
Entrez Gene 20539 (Evidence)
UniGene 27943
DFCI TC1575710, TC1592393, TC1748393
DoTS DT.101222912, DT.110849004, DT.110849022, DT.489652
NIA Mouse Gene Index U030347
Consensus CDS Project CCDS22730.1
International Mouse Phenotyping Consortium Status Slc7a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043045 VEGA Gene Model | MGI Sequence Detail 26545 C57BL/6J ±  kb
transcript OTTMUST00000112980 VEGA | MGI Sequence Detail 3517 Not Applicable 
polypeptide OTTMUSP00000063271 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(589 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004760 L-type amino acid transporter
Protein Ontology PR:000015201 large neutral amino acids transporter small subunit 1
References
(Earliest) J:48072 Kimura N, et al., Entactin-2: a new member of basement membrane protein with high homology to entactin/ nidogen. Exp Cell Res. 1998 May 25;241(1):36-45
(Latest) J:213820 Poncet N, et al., The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One. 2014;9(2):e89547
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory