Slc7a5
Gene Detail

Symbol Name ID

Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 MGI:1298205

Synonyms

D0H16S474E, LAT1, TA1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

70.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:121881146-121907686 bp, - strand From NCBI annotation of GRCm38   26541 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a5

Human homologs

Human Homolog		SLC7A5, solute carrier family 7 (amino acid transporter light chain, L system), member 5
NCBI Gene ID		8140
neXtProt AC		NX_Q01650
Human Synonyms		4F2LC, CD98, D16S469E, E16, hLAT1, LAT1, MPE16
Human Chr (Location)		16q24.3; chr16:87863629-87903100 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)
 

Mice homozygous for a targeted mutation die prenatally.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	cytoplasm, integral to membrane, ...
Function	amino acid transmembrane transporter activity, L-amino acid transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (46)    Images (23)
Theiler Stages: 1, 2, 3, 4, 5, 11, 15, 19, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	93
RT-PCR	38

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(82) cDNA(78) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000040010 (Evidence)
Entrez Gene	20539 (Evidence)
UniGene	27943
DFCI	TC1575710, TC1592393, TC1748393
DoTS	DT.101222912, DT.110849004, DT.110849022, DT.489652
NIA Mouse Gene Index	U030347
Consensus CDS Project	CCDS22730.1
International Mouse Knockout Project Status	Slc7a5

Sequences

Length	Strain/Species
genomic	20539	NCBI Gene Model | MGI Sequence Detail	26541	C57BL/6J
transcript	NM_011404	RefSeq | MGI Sequence Detail	3513	C57BL/6
polypeptide	Q9Z127	UniProt | EBI | MGI Sequence Detail	512	Not Applicable

All sequences(89) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(299 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002293	Amino acid/polyamine transporter I
InterPro	IPR004760	L-type amino acid transporter
Protein Ontology	PR:000015201	large neutral amino acids transporter small subunit 1

Graphical View of Protein Domain Structure

References

(Earliest) J:48072 Kimura N, et al., Entactin-2: a new member of basement membrane protein with high homology to entactin/ nidogen. Exp Cell Res. 1998 May 25;241(1):36-45
(Latest) J:189202 Abe S, et al., Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes. Endocrinology. 2012 Aug;153(8):4049-58
All references(38)