Lrp5
Gene Detail

Symbol Name ID

Lrp5 low density lipoprotein receptor-related protein 5 MGI:1278315

Synonyms

LR3, LRP7

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.33 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:3584828-3686564 bp, - strand From VEGA annotation of GRCm38   101737 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Lrp5 ± 2 cM)

Protein SuperFamily: low density lipoprotein receptor-related protein, 5/6 types
Gene Tree: Lrp5

Human ortholog

LRP5 low density lipoprotein receptor-related protein 5 NCBI Gene ID 4041
Human Synonyms: BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2
Human Chr11:68080108-68216743 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human LRP5 (7)

Alleles and phenotypes

All alleles(24) : Targeted(17) Gene trapped(6) Chemically induced(1)
 

Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.

 
Human Diseases Modeled Using Mouse Lrp5 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (82 annotations)

Process	adipose tissue development, anatomical structure regression, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	coreceptor activity, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (307)    Tissues (197)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 10, 18, 19, 20, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	198
Northern blot	12
RT-PCR	92

cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(89) Genomic(1) cDNA(81) Primer pair(6) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042195 (Evidence)
Ensembl Gene Model	ENSMUSG00000024913 (Evidence)
Entrez Gene	16973 (Evidence)
UniGene	274581
DFCI	TC1577532, TC1617568, TC1677577, TC1724610, TC1771917
DoTS	DT.101238699, DT.101734904, DT.110864077, DT.481503, DT.91429993, DT.97369430
NIA Mouse Gene Index	U019112
Consensus CDS Project	CCDS37881.1
International Mouse Knockout Project Status	Lrp5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042195	VEGA Gene Model | MGI Sequence Detail	101737	C57BL/6J
transcript	OTTMUST00000110769	VEGA | MGI Sequence Detail	5161	Not Applicable
polypeptide	OTTMUSP00000061850	VEGA | MGI Sequence Detail	1614	Not Applicable

All sequences(52) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(417 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR017049	Low density lipoprotein receptor-related protein, 5/6
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000009925	low-density lipoprotein receptor-related protein 5

References

(Earliest) J:49544 Hey PJ, et al., Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998 Aug 17;216(1):103-11
(Latest) J:193007 Goel S, et al., Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J Biol Chem. 2012 May 11;287(20):16454-66
All references(108)