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Gene Detail
low density lipoprotein receptor-related protein 5
Synonyms LR3, LRP7
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.33 cM, cytoband B
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr19:3584828-3686564 bp, - strand
From VEGA annotation of GRCm38

  101737 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1746  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: low density lipoprotein receptor-related protein, 5/6 types
Gene Tree: Lrp5

Human Homolog LRP5, low density lipoprotein receptor-related protein 5
NCBI Gene ID 4041
neXtProt AC  NX_O75197
Human Synonyms  BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
Human Chr (Location)  11q13.4; chr11:68312609-68449275 (+)  GRCh38
Disease Associations  (7) Diseases Associated with Human LRP5
alleles, and
All mutations/alleles(24) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.
Human Diseases Modeled Using Mouse Lrp5 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)
Lrp5 interacts with 470 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (82 annotations)
Process adipose tissue development, anatomical structure regression, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function coreceptor activity, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (34 records)
Data Summary: Results (458)    Tissues (345)    Images (32)
Theiler Stages: 1, 2, 3, 5, 10, 18, 19, 20, 22, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 353
Northern blot 12
cDNA source data(83)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(91) Genomic(1) cDNA(83) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000042195 (Evidence)
Ensembl Gene ModelENSMUSG00000024913 (Evidence)
Entrez Gene16973 (Evidence)
DFCITC1577532, TC1617568, TC1677577, TC1724610, TC1771917
DoTSDT.101238699, DT.101734904, DT.110864077, DT.481503, DT.91429993, DT.97369430
NIA Mouse Gene IndexU019112
Consensus CDS ProjectCCDS37881.1
International Mouse Knockout Project StatusLrp5
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042195 VEGA Gene Model | MGI Sequence Detail 101737 C57BL/6J ±  kb
transcript OTTMUST00000110769 VEGA | MGI Sequence Detail 5161 Not Applicable 
polypeptide OTTMUSP00000061850 VEGA | MGI Sequence Detail 1614 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(3) UniProt(6)
Polymorphisms SNPs within 2kb(544 from dbSNP Build 137)
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR017049 Low density lipoprotein receptor-related protein, 5/6
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009925 low-density lipoprotein receptor-related protein 5
References (Earliest) J:49544 Hey PJ, et al., Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998 Aug 17;216(1):103-11
(Latest) J:211171 Salazar VS, et al., Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype. J Cell Sci. 2013 Nov 1;126(Pt 21):4974-84
All references(115)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory