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Lrp5 Gene Detail
Summary
  • Symbol
    Lrp5
  • Name
    low density lipoprotein receptor-related protein 5
  • Synonyms
    LR3, LRP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278315
    NCBI Gene: 16973
  • Gene Overview
    MyGene.info: LRP5
Location & Maps
more
  • Sequence Map
    Chr19:3584828-3686564 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101737 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.33 cM, cytoband B
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LRP5, LDL receptor related protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRP5, LDL receptor related protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
  • Links
    NCBI Gene ID: 4041
    neXtProt AC: NX_O75197

  • Chr Location
    11q13.4; chr11:68298866-68449275 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Lrp5 mouse models; 7 with human LRP5 associations

Human Disease Mouse Models
       Exudative Vitreoretinopathy 4; EVR4   OMIM: 601813 View 1 model
Osteoporosis-Pseudoglioma Syndrome; OPPG   OMIM: 259770 View 3 models
       Endosteal Hyperostosis, Autosomal Dominant   OMIM: 144750
Exudative Vitreoretinopathy 1; EVR1   OMIM: 133780
Osteopetrosis, Autosomal Dominant 1; OPTA1   OMIM: 607634
Osteoporosis   OMIM: 166710
Van Buchem Disease, Type 2   OMIM: 607636
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 18 alleles in 17 genetic backgrounds
    64 phenotypes from multigenic genotypes
    7 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (ENU)
    1
  • Gene trapped
    6
  • Targeted
    17
  • Transgenic
    2
  • Incidental Mutations
Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042195 VEGA Gene Model | MGI Sequence Detail 101737 C57BL/6J ±  kb
transcript OTTMUST00000110769 VEGA | MGI Sequence Detail 5161 Not Applicable  
polypeptide OTTMUSP00000061850 VEGA | MGI Sequence Detail 1614 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    538 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009925 low-density lipoprotein receptor-related protein 5
  • InterPro Domains
    IPR000742 EGF-like domain
    IPR000033 LDLR class B repeat
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR017049 Low density lipoprotein receptor-related protein 5/6
    IPR011042 Six-bladed beta-propeller, TolB-like
Molecular
Reagents
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  • All nucleic 91
    Genomic 1
    cDNA 83
    Primer pair 6
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 132
    Developmental Gene Expression 36
    Diseases 5
    Gene Ontology 27
    Phenotypes 65
  • Earliest
    J:49544 Hey PJ, et al., Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998 Aug 17;216(1):103-11
  • Latest
    J:233071 D'Amico L, et al., Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer. J Exp Med. 2016 May 2;213(5):827-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory