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Lrp5 Gene Detail
Summary
  • Symbol
    Lrp5
  • Name
    low density lipoprotein receptor-related protein 5
  • Synonyms
    LR3, LRP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278315
    NCBI Gene: 16973
  • Gene Overview
    MyGene.info: LRP5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:3584828-3686564 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101737 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.33 cM, cytoband B
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LRP5, LDL receptor related protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRP5, LDL receptor related protein 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, PCLD4, VBCH2
  • Links
    NCBI Gene ID: 4041
    neXtProt AC: NX_O75197
    UniProt: O75197

  • Chr Location
    11q13.2; chr11:68298866-68449275 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Lrp5 mouse models; 5 with human LRP5 associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 3 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 19 alleles in 18 genetic backgrounds
    64 phenotypes from multigenic genotypes
    7 images
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042195 VEGA Gene Model | MGI Sequence Detail 101737 C57BL/6J ±  kb
    transcript OTTMUST00000110769 VEGA | MGI Sequence Detail 5161 Not Applicable  
    polypeptide OTTMUSP00000061850 VEGA | MGI Sequence Detail 1614 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      538 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009925 low-density lipoprotein receptor-related protein 5
    • InterPro Domains
      IPR000742 EGF-like domain
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR017049 Low density lipoprotein receptor-related protein 5/6
      IPR011042 Six-bladed beta-propeller, TolB-like
    Molecular
    Reagents
    less
    • All nucleic 94
      Genomic 1
      cDNA 84
      Primer pair 7
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 41
      Diseases 5
      Gene Ontology 28
      Phenotypes 79
    • Earliest
      J:49544 Hey PJ, et al., Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998 Aug 17;216(1):103-11
    • Latest
      J:261495 Swafford D, et al., Canonical Wnt Signaling in CD11c(+) APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon. J Immunol. 2018 May 1;200(9):3259-3268

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory