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Symbol
Name
ID 		Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Frontal bossing
Craniofacial hyperostosis
Thickened calvaria
Mandibular pain
Mandibular prognathia
Calvarial osteosclerosis
Microcephaly
Wormian bones
Tibial bowing
Diaphyseal undertubulation
Metatarsal diaphyseal endosteal sclerosis
Abnormal lower limb bone morphology
Abnormal femoral neck/head morphology
Metaphyseal widening
Metacarpal diaphyseal endosteal sclerosis
Retinal calcification
Joint hypermobility
Increased susceptibility to fractures
Pathologic fracture
Recurrent fractures
Crumpled long bones
Thickened cortex of long bones
Abnormal pelvic girdle bone morphology
Clavicular sclerosis
Abnormal rib morphology
Barrel-shaped chest
Abnormality of the vertebral column
Kyphosis
Kyphoscoliosis
Scoliosis
Abnormal form of the vertebral bodies
Biconcave vertebral bodies
Platyspondyly
Severe platyspondyly
Sclerotic vertebral body
Vertebral compression fracture
Back pain
Generalized osteosclerosis
Osteopetrosis
Osteopenia
Osteoporosis
Abnormal cortical bone morphology
Hyperostosis
Disease(s) Associated with LRP5
autosomal dominant osteopetrosis 1
exudative vitreoretinopathy 4
osteoporosis
osteoporosis-pseudoglioma syndrome
polycystic liver disease
Worth syndrome

Mouse Phenotypes
skeleton phenotype
decreased osteoblast proliferation
abnormal osteoblast physiology
thin parietal bone
decreased osteoclast cell number
abnormal phalanx morphology
abnormal femur morphology
decreased diameter of femur
decreased diameter of tibia
abnormal long bone diaphysis morphology
abnormal lumbar vertebrae morphology
abnormal bone structure
decreased bone mineral content
decreased areal bone mineral density
decreased bone mineral density of femur
decreased bone mineral density
increased bone mineral density
decreased bone volume
decreased compact bone mass
decreased osteoblast cell number
abnormal trabecular bone morphology
abnormal bone trabecula morphology
decreased trabecular bone mass
decreased bone mass
osteoporosis
increased bone mass
abnormal bone ossification
abnormal bone mineralization
decreased bone mineralization
decreased bone ossification
delayed bone ossification
increased bone ossification
decreased bone resorption
decreased bone stiffness
decreased bone strength
fragile skeleton
Availability Mouse Genotype
Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Lrp5m1Btlr/Lrp5m1Btlr
Lrp5m3Btlr/Lrp5m3Btlr
Lrp5m4Btlr/Lrp5m4Btlr
Lrp5tm1.1Mawa/Lrp5tm1.1Mawa
Lrp5tm1.2Vari/Lrp5tm1.2Vari *
Lrp5tm1Grw/Lrp5tm1Grw
Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp5tm1Jsak/Lrp5tm1Jsak
Lrp5tm1Kry/Lrp5tm1Kry *
Lrp5tm1Lex/Lrp5tm1Lex
Lrp5tm2.1Mawa/Lrp5tm2.1Mawa
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Lrp5tvrm111B/Lrp5tvrm111B
Lrp5m1Btlr/Lrp5+
Lrp5m2Btlr/Lrp5+
Lrp5tm1.1Mawa/Lrp5+
Lrp5tm1Kry/Lrp5+
Lrp5tm1Lex/Lrp5+
Lrp5tm1Mawa/Lrp5+ *
Lrp5tm2.1Mawa/Lrp5+
Lrp5tm2Mawa/Lrp5+ *
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0  (conditional)		 *
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0  (conditional)		 *
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Dmp1-cre)1Jqfe/0  (conditional)
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Vil1-cre)997Gum/0  (conditional)		 *
Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+  (conditional)		 *
Lrp5tm1Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0  (conditional)
Lrp5tm1Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0  (conditional)		 *
Lrp5tm1Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0  (conditional)
Lrp5tm2Kry/Lrp5+
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm2Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0  (conditional)
Lrp5tm2Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0  (conditional)		 *
Lrp5tm2Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory