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Symbol Name ID |
Lrp5
low density lipoprotein receptor-related protein 5 MGI:1278315 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Vitreous hemorrhage |
Peripheral retinal avascularization |
Peripheral retinal neovascularization |
Posterior retinal neovascularization |
Absent anterior chamber of the eye |
Corneal opacity |
Cataract |
Subcapsular cataract |
Iris atrophy |
Retinal detachment |
Tractional retinal detachment |
Falciform retinal fold |
Retinal calcification |
Retinal exudate |
Exudative retinopathy |
Large hyperpigmented retinal spots |
Abnormal vitreous humor morphology |
Posterior vitreous detachment |
Vitreoretinopathy |
Exudative vitreoretinopathy |
Blue sclerae |
Uveitis |
Microphthalmia |
Phthisis bulbi |
Abnormal electroretinogram |
Nystagmus |
Congenital nystagmus |
Horizontal pendular nystagmus |
Reduced visual acuity |
Blindness |
Congenital blindness |
Moderately reduced visual acuity |
Severely reduced visual acuity |
Visual acuity light perception with projection |
Angle closure glaucoma |
| Disease(s) Associated with LRP5 | |||||||||||||||||||||||||||||||||||
| exudative vitreoretinopathy 4 | |||||||||||||||||||||||||||||||||||
| neovascular inflammatory vitreoretinopathy | |||||||||||||||||||||||||||||||||||
| osteoporosis-pseudoglioma syndrome | |||||||||||||||||||||||||||||||||||
| Worth syndrome |
| Mouse Phenotypes | vision/eye phenotype |
abnormal retina vasculature morphology |
abnormal retina blood vessel morphology |
retina ganglion cell degeneration |
retina photoreceptor degeneration |
abnormal blood-retina barrier function |
abnormal retina pigment epithelium morphology |
abnormal eye development |
abnormal retina development |
persistence of hyaloid vascular system |
abnormal retina morphology |
abnormal retina layer morphology |
abnormal retina neuronal layer morphology |
disorganized retina inner nuclear layer |
thin retina inner plexiform layer |
abnormal retina nerve fiber layer morphology |
abnormal retina outer nuclear layer morphology |
thin retina outer nuclear layer |
disorganized retina outer nuclear layer |
abnormal retina outer plexiform layer morphology |
disorganized retina outer plexiform layer |
thin retina outer plexiform layer |
increased susceptibility to age-related retinal degeneration |
decreased total retina thickness |
retina fold |
decreased a-wave amplitude |
abnormal b-wave shape |
decreased b-wave amplitude |
abnormal cone electrophysiology |
abnormal vision |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Lrp5em1Xjz/Lrp5em1Xjz | |||||||||||||||||||||||||||||||
| Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex | |||||||||||||||||||||||||||||||
| Lrp5r18/Lrp5r18 | |||||||||||||||||||||||||||||||
| Lrp5tm1Dgen/Lrp5tm1Dgen | |||||||||||||||||||||||||||||||
| Lrp5tm1Kry/Lrp5tm1Kry | |||||||||||||||||||||||||||||||
| Lrp5tm1Lex/Lrp5tm1Lex | |||||||||||||||||||||||||||||||
| Lrp5tvrm111B/Lrp5tvrm111B | |||||||||||||||||||||||||||||||
| Lrp5tm2Kry/Lrp5tm2Kry Tg(Col1a1-cre)1Kry/0 (conditional) |
* | ||||||||||||||||||||||||||||||
| Lrp5tm2Kry/Lrp5tm2Kry Tg(Vil1-cre)20Syr/0 (conditional) |
* | ||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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