Casp8
Gene Detail

Symbol Name ID

Casp8 caspase 8 MGI:1261423

Synonyms

Caspase-8, FLICE, MACH, Mch5

Feature Type

protein coding gene

Genetic Map

Chromosome 1

29.19 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr1:58795374-58847503 bp, + strand From NCBI annotation of GRCm38   52130 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Casp8 and Fadd-like apoptosis regulator/caspase, types 8/10
Gene Tree: Casp8

Human homologs

Human Homolog		CASP8, caspase 8, apoptosis-related cysteine peptidase
NCBI Gene ID		841
neXtProt AC		NX_Q14790
Human Synonyms		ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Human Chr (Location)		2q33-q34; chr2:202098166-202152434 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human CASP8

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygotes for a targeted null mutation exhibit impaired cardiac muscle development, cardiac erythrocyte congestion, low numbers of colony-forming cells, and prenatal lethality. T-cell restricted knockout mice are viable, but immunodeficient.

 
Human Diseases Modeled Using Mouse Casp8 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component	CD95 death-inducing signaling complex, cell body, ...
Function	cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (95)    Tissues (62)    Images (18)
Theiler Stages: 1, 2, 3, 5, 10, 15, 17, 18, 19, 21, 23, 25, 28

Assay Type	Results
RNA in situ	53
Northern blot	23
RT-PCR	14
RNase protection	5

cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(14) cDNA(34) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026029 (Evidence)
Entrez Gene	12370 (Evidence)
UniGene	336851
DFCI	TC1576359, TC1693128
DoTS	DT.101370778, DT.101370779, DT.101400969, DT.87072360
NIA Mouse Gene Index	U000313
EC	3.4.22.61
Consensus CDS Project	CCDS14979.1
International Mouse Knockout Project Status	Casp8

Sequences

Length	Strain/Species
genomic	12370	NCBI Gene Model | MGI Sequence Detail	52130	C57BL/6J
transcript	NM_009812	RefSeq | MGI Sequence Detail	2585	C57BL/6
polypeptide	O89110	UniProt | EBI | MGI Sequence Detail	480	Not Applicable

All sequences(41) RefSeq(6) UniProt(3)

Polymorphisms

PCR(1) : SNPs(119 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001875	Death effector domain
InterPro	IPR011029	Death-like domain
InterPro	IPR011600	Peptidase C14, caspase catalytic
InterPro	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
InterPro	IPR002398	Peptidase C14, caspase precursor p45
InterPro	IPR015917	Peptidase C14, caspase precursor p45, core
InterPro	IPR001309	Peptidase C14, ICE, catalytic subunit p20
InterPro	IPR016129	Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology	PR:000002317	caspase-8

Graphical View of Protein Domain Structure

References

(Earliest) J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
(Latest) J:192616 Kang TB, et al., Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome. Immunity. 2013 Jan 24;38(1):27-40
All references(128)