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Casp8
Gene Detail
Symbol

Name
ID
Casp8
caspase 8
MGI:1261423
Synonyms
Caspase-8, FLICE, MACH, Mch5
Feature Type
protein coding gene
Genetic Map
Chromosome 1
29.19 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr1:58795374-58847503 bp, + strand
From VEGA annotation of GRCm38

  52130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CASP8
Protein SuperFamily: Casp8 and Fadd-like apoptosis regulator/caspase, types 8/10
Gene Tree: Casp8

Human
homologs
CASP8, caspase 8, apoptosis-related cysteine peptidase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 841
neXtProt AC: NX_Q14790

Human Synonyms: ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5

Human Chr (Location): 2q33-q34; chr2:201233443-201287711 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human CASP8

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit impaired cardiac muscle development, cardiac erythrocyte congestion, low numbers of colony-forming cells, and prenatal lethality. T-cell restricted knockout mice are viable, but immunodeficient.
 
Human Diseases Modeled in Mice Using Casp8 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Casp8 interacts with 161 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (26 records)
Data Summary: Results (91)    Tissues (60)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
Northern blot 23
RT-PCR 10
RNase protection 5
cDNA source data(33)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495471 ; ZFIN casp8    NEW 
Molecular
reagents
All nucleic(51) Genomic(14) cDNA(34) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000047216 (Evidence)
Ensembl Gene Model ENSMUSG00000026029 (Evidence)
Entrez Gene 12370 (Evidence)
UniGene 336851
DFCI TC1576359, TC1693128
DoTS DT.101370778, DT.101370779, DT.101400969, DT.87072360
NIA Mouse Gene Index U000313
EC 3.4.22.61
Consensus CDS Project CCDS14979.1, CCDS78590.1
International Mouse Phenotyping Consortium Status Casp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047216 VEGA Gene Model | MGI Sequence Detail 52130 C57BL/6J ±  kb
transcript OTTMUST00000122094 VEGA | MGI Sequence Detail 1628 Not Applicable 
polypeptide OTTMUSP00000067072 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(8) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(245 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
Protein-related
information
ResourceIDDescription
InterPro IPR029030 Caspase-like domain
InterPro IPR001875 Death effector domain
InterPro IPR011029 Death-like domain
InterPro IPR015917 Peptidase C14A, caspase precursor p45, core
InterPro IPR011600 Peptidase C14, caspase domain
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002317 caspase-8
References
(Earliest) J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
(Latest) J:223015 Kang S, et al., Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015;6:7515
All references(174)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory