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Gene Detail
caspase 8
Synonyms Caspase-8, FLICE, MACH, Mch5
Feature Type protein coding gene
Genetic Map
Chromosome 1
29.19 cM, cytoband B
Detailed Genetic Map ± 1 cM

Mapping data(11)
Sequence Map
Chr1:58795374-58847503 bp, + strand
From VEGA annotation of GRCm38

  52130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:7657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Casp8 and Fadd-like apoptosis regulator/caspase, types 8/10
Gene Tree: Casp8

Human Homolog CASP8, caspase 8, apoptosis-related cysteine peptidase
NCBI Gene ID 841
neXtProt AC  NX_Q14790
Human Synonyms  ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Human Chr (Location)  2q33-q34; chr2:201233443-201287711 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human CASP8
alleles, and
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a targeted null mutation exhibit impaired cardiac muscle development, cardiac erythrocyte congestion, low numbers of colony-forming cells, and prenatal lethality. T-cell restricted knockout mice are viable, but immunodeficient.
Human Diseases Modeled Using Mouse Casp8 (2)    Alleles Annotated to Human Diseases(2)   
Casp8 interacts with 162 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (87 annotations)
Process activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component CD95 death-inducing signaling complex, cell body, ...
Function cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, ...
External Resources: FuncBase
Literature Summary: (24 records)
Data Summary: Results (91)    Tissues (60)    Images (18)
Theiler Stages: 1, 2, 3, 5, 10, 15, 17, 18, 19, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 53
Northern blot 23
RNase protection 5
cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(51) Genomic(14) cDNA(34) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000047216 (Evidence)
Ensembl Gene ModelENSMUSG00000026029 (Evidence)
Entrez Gene12370 (Evidence)
DFCITC1576359, TC1693128
DoTSDT.101370778, DT.101370779, DT.101400969, DT.87072360
NIA Mouse Gene IndexU000313
Consensus CDS ProjectCCDS14979.1
International Mouse Knockout Project StatusCasp8
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047216 VEGA Gene Model | MGI Sequence Detail 52130 C57BL/6J ±  kb
transcript OTTMUST00000122092 VEGA | MGI Sequence Detail 1849 Not Applicable 
polypeptide OTTMUSP00000067070 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(245 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
InterPro IPR001875 Death effector domain
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002317 caspase-8
References (Earliest) J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
(Latest) J:211055 Weng D, et al., Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6
All references(155)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory