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Symbol
Name
ID

Casp8
caspase 8
MGI:1261423

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Reduced CD95-induced lymphocyte apoptosis	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine	Defective B cell activation	Decreased T cell activation
Disease(s) Associated with CASP8
autoimmune lymphoproliferative syndrome type 2B

Mouse Phenotypes		myocardium necrosis	increased cardiomyocyte apoptosis	abnormal cell death	decreased T cell apoptosis	decreased apoptosis	increased apoptosis	abnormal macrophage differentiation	decreased B cell proliferation	abnormal T cell proliferation	decreased T cell proliferation
Availability	Mouse Genotype	myocardium necrosis	increased cardiomyocyte apoptosis	abnormal cell death	decreased T cell apoptosis	decreased apoptosis	increased apoptosis	abnormal macrophage differentiation	decreased B cell proliferation	abnormal T cell proliferation	decreased T cell proliferation
	Casp8^em1Hbz/Casp8^em1Hbz
	Casp8^tm1Syon/Casp8^tm1Syon
	Casp8^tm1Yuan/Casp8^tm1Yuan
	Casp8^tm1Hed/Casp8^tm1Hed Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)
	Casp8^tm1Raz/Casp8^tm1Raz Tg(Lck-cre)548Jxm/0 (conditional)
	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Tie1-cre)9Ref/0 (conditional)
	Casp8^tm1Wll/Casp8^tm1.1Yuan Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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