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Nr2e1
Gene Detail
Symbol

Name
ID
Nr2e1
nuclear receptor subfamily 2, group E, member 1
MGI:1100526
Synonyms
Mtll, Nr2e1, tailless, Tlx
Feature Type
protein coding gene
Genetic Map
Chromosome 10
22.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:42561963-42583632 bp, - strand
From VEGA annotation of GRCm38

  21670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR2E1
Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2e1

Human
homologs
NR2E1, nuclear receptor subfamily 2, group E, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7101
neXtProt AC: NX_Q9Y466

Human Synonyms: TLL, TLX, XTLL

Human Chr (Location): 6q21; chr6:108158115-108188809 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Spontaneous(1) Targeted(7)
Incidental mutations (data from APF , CvDC )
 
Homozygotes have small brains, hypoplasia of cerebrum and olfactory lobes, thin optic layers, reduced retinal vessels and hydrocephaly on some genetic backgrounds. Mutants do poorly in sensorimotor tests, are aggressive and females lack maternal behavior.
 
Interactions
Nr2e1 interacts with 217 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process aggressive behavior, amygdala development, ...
Component nucleus
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (354)    Tissues (178)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 342
RT-PCR 12
cDNA source data(27)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NR2E1 ; Xenbase nr2e1 ; ZFIN nr2e1    NEW 
Molecular
reagents
All nucleic(31) Genomic(1) cDNA(27) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000019463 (Evidence)
Ensembl Gene Model ENSMUSG00000019803 (Evidence)
Entrez Gene 21907 (Evidence)
UniGene 287100
DFCI TC1581851
DoTS DT.110609993, DT.99708574
NIA Mouse Gene Index U031732
Consensus CDS Project CCDS23813.1
International Mouse Phenotyping Consortium Status Nr2e1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019463 VEGA Gene Model | MGI Sequence Detail 21670 C57BL/6J ±  kb
transcript OTTMUST00000046480 VEGA | MGI Sequence Detail 3285 Not Applicable 
polypeptide OTTMUSP00000020988 VEGA | MGI Sequence Detail 385 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011402 nuclear receptor subfamily 2 group E member 1
References
(Earliest) J:13044 Carter TC, The genetics of luxate mice. III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet. 1953;51(3):443-457
(Latest) J:222296 Huang Y, et al., Single-cell-level spatial gene expression in the embryonic neural differentiation niche. Genome Res. 2015 Apr;25(4):570-81
All references(81)
Other
accession IDs
MGI:1891035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory