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Nr2e1
Gene Detail
 Symbol
Name
ID
Nr2e1
nuclear receptor subfamily 2, group E, member 1
MGI:1100526
Synonyms Mtll, Nr2e1, tailless, Tlx
Feature Type protein coding gene
Genetic Map
Chromosome 10
22.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:42561963-42583632 bp, - strand
From VEGA annotation of GRCm38

  21670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2e1

Human
homologs
Human Homolog NR2E1, nuclear receptor subfamily 2, group E, member 1
NCBI Gene ID 7101
neXtProt AC  NX_Q9Y466
Human Synonyms  TLL, TLX, XTLL
Human Chr (Location)  6q21; chr6:108166058-108188809 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from APF )
 
Homozygotes have small brains, hypoplasia of cerebrum and olfactory lobes, thin optic layers, reduced retinal vessels and hydrocephaly on some genetic backgrounds. Mutants do poorly in sensorimotor tests, are aggressive and females lack maternal behavior.
 
Interactions
Nr2e1 interacts with 217 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process aggressive behavior, amygdala development, ...
Component nucleus
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (354)    Tissues (178)    Images (67)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 342
RT-PCR 12
cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(1) cDNA(27) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000019463 (Evidence)
Ensembl Gene ModelENSMUSG00000019803 (Evidence)
Entrez Gene21907 (Evidence)
UniGene287100
DFCITC1581851
DoTSDT.110609993, DT.99708574
NIA Mouse Gene IndexU031732
Consensus CDS ProjectCCDS23813.1
International Mouse Knockout Project StatusNr2e1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019463 VEGA Gene Model | MGI Sequence Detail 21670 C57BL/6J ±  kb
transcript OTTMUST00000046480 VEGA | MGI Sequence Detail 3285 Not Applicable 
polypeptide OTTMUSP00000020988 VEGA | MGI Sequence Detail 385 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011402 nuclear receptor subfamily 2 group E member 1
References (Earliest) J:13044 Carter TC, The genetics of luxate mice. III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet. 1953;51(3):443-457
(Latest) J:212097 Murai K, et al., Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9115-20
All references(81)
Other
accession IDs
MGI:1891035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory