Nr2e1
Gene Detail

Symbol Name ID

Nr2e1 nuclear receptor subfamily 2, group E, member 1 MGI:1100526

Synonyms

Mtll, Nr2e1, tailless, Tlx

Feature Type

protein coding gene

Genetic Map

Chromosome 10

22.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:42561963-42583632 bp, - strand From VEGA annotation of GRCm38   21670 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37750  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2e1

Human homologs

Human Homolog		NR2E1, nuclear receptor subfamily 2, group E, member 1
NCBI Gene ID		7101
neXtProt AC		NX_Q9Y466
Human Synonyms		TLL, TLX, XTLL
Human Chr (Location)		6q21; chr6:108487215-108510013 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

Homozygotes have small brains, hypoplasia of cerebrum and olfactory lobes, thin optic layers, reduced retinal vessels and hydrocephaly on some genetic backgrounds. Mutants do poorly in sensorimotor tests, are aggressive and females lack maternal behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (67 annotations)

Process	aggressive behavior, amygdala development, ...
Component	nucleus
Function	DNA binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (361)    Tissues (182)    Images (67)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	342
RT-PCR	19

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(1) cDNA(27) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000019463 (Evidence)
Ensembl Gene Model	ENSMUSG00000019803 (Evidence)
Entrez Gene	21907 (Evidence)
UniGene	287100
DFCI	TC1581851
DoTS	DT.110609993, DT.99708574
NIA Mouse Gene Index	U031732
Consensus CDS Project	CCDS23813.1
International Mouse Knockout Project Status	Nr2e1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019463	VEGA Gene Model | MGI Sequence Detail	21670	C57BL/6J
transcript	OTTMUST00000046480	VEGA | MGI Sequence Detail	3285	Not Applicable
polypeptide	OTTMUSP00000020988	VEGA | MGI Sequence Detail	385	Not Applicable

All sequences(36) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(116 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR003068	Transcription factor COUP
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011402	nuclear receptor subfamily 2 group E member 1

References

(Earliest) J:13044 Carter TC, The genetics of luxate mice. III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet. 1953;51(3):443-457
(Latest) J:192734 Zou Y, et al., The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol. 2012 Dec;32(23):4811-20
All references(77)

Other accession IDs

MGI:1891035