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Tnfrsf11b
Gene Detail
 Symbol
Name
ID
Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
MGI:109587
Synonyms OCIF, Opg, OPG, osteoclastogenesis inhibitory factor, TR1
Feature Type protein coding gene
Genetic Map
Chromosome 15
21.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:54250619-54278484 bp, - strand
From NCBI annotation of GRCm38

  27866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tumor necrosis factor receptor superfamily member 11B
Gene Tree: Tnfrsf11b

Human
homologs
Human Homolog TNFRSF11B, tumor necrosis factor receptor superfamily, member 11b
NCBI Gene ID 4982
neXtProt AC  NX_O00300
Human Synonyms  OCIF, OPG, TR1
Human Chr (Location)  8q24; chr8:118923557-118952144 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TNFRSF11B
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation. Progressive hearing loss also results due to abnormal remodeling of the otic capsule.
 
Interactions
Tnfrsf11b interacts with 218 markers (Mir19a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process apoptotic process, extracellular matrix organization, ...
Component extracellular region, extracellular space, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (56)    Tissues (45)   
Theiler Stages: 7, 9, 10, 11, 13, 15, 17, 18, 19, 20, 23, 25, 26, 28
Assay TypeResults
RNA in situ 16
Northern blot 23
RT-PCR 17
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(29) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000063727 (Evidence)
Entrez Gene18383 (Evidence)
UniGene15383
DFCITC1581828
DoTSDT.40137867
NIA Mouse Gene IndexU036172
PDB4E4D
Consensus CDS ProjectCCDS27468.1
International Mouse Knockout Project StatusTnfrsf11b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18383 NCBI Gene Model | MGI Sequence Detail 27866 C57BL/6J ±  kb
transcript NM_008764 RefSeq | MGI Sequence Detail 2818 C57BL/6 
polypeptide O08712 UniProt | EBI | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(383 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022323 Tumour necrosis factor receptor 11
InterPro IPR017371 Tumour necrosis factor receptor 11B
Protein Ontology PR:000016480 tumor necrosis factor receptor superfamily member 11B
Graphical View of Protein Domain Structure
References (Earliest) J:39641 Simonet WS, et al., Osteoprotegerin: a novel secreted protein involved in the regulation of bone density [see comments]. Cell. 1997 Apr 18;89(2):309-19
(Latest) J:211351 Shimamura M, et al., OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8191-6
All references(82)
Other
accession IDs
MGD-MRK-39586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory