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Tnfrsf11b Gene Detail
Summary
  • Symbol
    Tnfrsf11b
  • Name
    tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • Synonyms
    OCIF, Opg, OPG, osteoclastogenesis inhibitory factor, TR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109587
    NCBI Gene: 18383
  • Gene Overview
    MyGene.info: TNFRSF11B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54250619-54278484 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 21.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109587
protein coding gene Chr15:54250619-54278484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021846
protein coding gene Chr15:53291391-53323857 (-)
A/J MGP_AJ_G0021806
protein coding gene Chr15:51175610-51203457 (-)
AKR/J MGP_AKRJ_G0021787
protein coding gene Chr15:52618733-52646595 (-)
BALB/cJ MGP_BALBcJ_G0021813
protein coding gene Chr15:51402513-51430364 (-)
C3H/HeJ MGP_C3HHeJ_G0021587
protein coding gene Chr15:52713001-52740871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022252
protein coding gene Chr15:55377557-55406206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019789
protein coding gene Chr15:48454156-48482076 (-)
CAST/EiJ MGP_CASTEiJ_G0021104
protein coding gene Chr15:53278640-53307077 (-)
CBA/J MGP_CBAJ_G0021556
protein coding gene Chr15:57348446-57377768 (-)
DBA/2J MGP_DBA2J_G0021680
protein coding gene Chr15:51064441-51092124 (-)
FVB/NJ MGP_FVBNJ_G0021658
protein coding gene Chr15:50213674-50241470 (-)
LP/J MGP_LPJ_G0021750
protein coding gene Chr15:53100485-53128126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021682
protein coding gene Chr15:62409668-62440678 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022275
protein coding gene Chr15:52966374-52994226 (-)
PWK/PhJ MGP_PWKPhJ_G0020849
protein coding gene Chr15:51135535-51163779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020686
protein coding gene Chr15:52707516-52734766 (-)
WSB/EiJ MGP_WSBEiJ_G0021159
protein coding gene Chr15:52956537-52987377 (-)



Homology
more
  • Human Ortholog
    TNFRSF11B, TNF receptor superfamily member 11b
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFRSF11B, TNF receptor superfamily member 11b
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OCIF, OPG, PDB5, TR1
  • Links
    NCBI Gene ID: 4982
    neXtProt AC: NX_O00300
    UniProt: O00300

  • Chr Location
    8q24.12; chr8:118923557-118952144 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation. Progressive hearing loss also results due to abnormal remodeling of the otic capsule.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18383 NCBI Gene Model | MGI Sequence Detail 27866 C57BL/6J ±  kb
    transcript NM_008764 RefSeq | MGI Sequence Detail 2818 C57BL/6  
    polypeptide O08712 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39586
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 9
      Phenotypes 52
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:258336 Barrott JJ, et al., Paracrine osteoprotegerin and beta-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest. 2018 Jan 2;128(1):207-218

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory