Tnfrsf11b
Gene Detail

Symbol Name ID

Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) MGI:109587

Synonyms

OCIF, Opg, OPG, osteoclastogenesis inhibitory factor, TR1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

21.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:54250619-54278484 bp, - strand From NCBI annotation of GRCm38   27866 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor receptor superfamily member 11B
Gene Tree: Tnfrsf11b

Human homologs

Human Homolog		TNFRSF11B, tumor necrosis factor receptor superfamily, member 11b
NCBI Gene ID		4982
neXtProt AC		NX_O00300
Human Synonyms		OCIF, OPG, TR1
Human Chr (Location)		8q24; chr8:119935796-119964383 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TNFRSF11B

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation. Progressive hearing loss also results due to abnormal remodeling of the otic capsule.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	apoptotic process, extracellular matrix organization, ...
Component	extracellular region, extracellular space, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (56)    Tissues (45)   
Theiler Stages: 7, 9, 10, 11, 13, 15, 17, 18, 19, 20, 23, 25, 26, 28

Assay Type	Results
RNA in situ	16
Northern blot	23
RT-PCR	17

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(29) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000063727 (Evidence)
Entrez Gene	18383 (Evidence)
UniGene	15383
DFCI	TC1581828
DoTS	DT.40137867
NIA Mouse Gene Index	U036172
PDB	4E4D
Consensus CDS Project	CCDS27468.1
International Mouse Knockout Project Status	Tnfrsf11b

Sequences

Length	Strain/Species
genomic	18383	NCBI Gene Model | MGI Sequence Detail	27866	C57BL/6J
transcript	NM_008764	RefSeq | MGI Sequence Detail	2818	C57BL/6
polypeptide	O08712	UniProt | EBI | MGI Sequence Detail	401	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(236 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR022323	Tumour necrosis factor receptor 11
InterPro	IPR017371	Tumour necrosis factor receptor 11B
Protein Ontology	PR:000016480	tumor necrosis factor receptor superfamily member 11B

Graphical View of Protein Domain Structure

References

(Earliest) J:39641 Simonet WS, et al., Osteoprotegerin: a novel secreted protein involved in the regulation of bone density [see comments]. Cell. 1997 Apr 18;89(2):309-19
(Latest) J:194767 Koide M, et al., Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: comparison with RANKL-overexpressing transgenic male mice. Endocrinology. 2013 Feb;154(2):773-82
All references(77)

Other accession IDs

MGD-MRK-39586