About   Help   FAQ
Pld1 Gene Detail
Summary
  • Symbol
    Pld1
  • Name
    phospholipase D1
  • Synonyms
    Pld1a, Pld1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109585
    NCBI Gene: 18805
Location & Maps
more
  • Sequence Map
    Chr3:27938695-28133362 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      194668 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLD1, phospholipase D1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PLD1, phospholipase D1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 5337
    neXtProt AC: NX_Q13393

  • Chr Location
    3q26; chr3:171600405-171810494 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Pld1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced growth, vascularization and metastasis of implanted tumor cells and decreased neoangiogenesis. Mice homozygous for a different knock-out allele exhibit abnormal autophagy in the liver of food restricted mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028207 VEGA Gene Model | MGI Sequence Detail 194668 C57BL/6J ±  kb
transcript OTTMUST00000069880 VEGA | MGI Sequence Detail 3732 Not Applicable  
polypeptide OTTMUSP00000035549 VEGA | MGI Sequence Detail 1074 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1634 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 52
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-39584, MGI:2139589, MGI:2140090
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:38674 Hammond SM, et al., Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem. 1997 Feb 7;272(6):3860-8
  • Latest
    J:226449 Kang DW, et al., Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling beta-catenin signaling in cancer-initiating cells. J Exp Med. 2015 Jul 27;212(8):1219-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory