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Pld1
Gene Detail
Symbol

Name
ID
Pld1
phospholipase D1
MGI:109585
Synonyms
Pld1a, Pld1b
Feature Type
protein coding gene
Genetic Map
Chromosome 3
11.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:27938695-28133362 bp, + strand
From VEGA annotation of GRCm38

  194668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:116234  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: phospholipase D, eukaryotic type
Gene Tree: Pld1

Human
homologs
Human Homolog PLD1, phospholipase D1, phosphatidylcholine-specific
NCBI Gene ID 5337
neXtProt AC  NX_Q13393
Human Chr (Location)  3q26; chr3:171600405-171810494 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced growth, vascularization and metastasis of implanted tumor cells and decreased neoangiogenesis. Mice homozygous for a different knock-out allele exhibit abnormal autophagy in the liver of food restricted mice.
 
Interactions
Pld1 interacts with 273 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process defense response to Gram-positive bacterium, lipid catabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (143)    Tissues (143)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(51) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000028207 (Evidence)
Ensembl Gene ModelENSMUSG00000027695 (Evidence)
Entrez Gene18805 (Evidence)
UniGene212039
DFCITC1580474, TC1686501
DoTSDT.101373903, DT.103562423, DT.488305, DT.94150013
NIA Mouse Gene IndexU003097
EC3.1.4.4
Consensus CDS ProjectCCDS17275.1
International Mouse Knockout Project StatusPld1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028207 VEGA Gene Model | MGI Sequence Detail 194668 C57BL/6J ±  kb
transcript OTTMUST00000069877 VEGA | MGI Sequence Detail 4849 Not Applicable 
polypeptide OTTMUSP00000035546 VEGA | MGI Sequence Detail 1036 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(10) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(1634 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016555 Phospholipase D, eukaryota
InterPro IPR015679 Phospholipase D family
InterPro IPR025202 Phospholipase D-like domain
InterPro IPR001736 Phospholipase D/Transphosphatidylase
InterPro IPR001683 Phox homologous domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012843 phospholipase D1
References
(Earliest) J:38674 Hammond SM, et al., Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem. 1997 Feb 7;272(6):3860-8
(Latest) J:210378 Wegener JW, et al., Phospholipase D1 is involved in alpha1-adrenergic contraction of murine vascular smooth muscle. FASEB J. 2014 Mar;28(3):1044-8
All references(67)
Other
accession IDs
MGD-MRK-39584, MGI:2139589, MGI:2140090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory