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Pld1 Gene Detail
Summary
  • Symbol
    Pld1
  • Name
    phospholipase D1
  • Synonyms
    Pld1a, Pld1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109585
    NCBI Gene: 18805
  • Gene Overview
    MyGene.info: PLD1
Location & Maps
more
  • Sequence Map
    Chr3:27938695-28133362 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      194668 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 11.15 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PLD1, phospholipase D1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PLD1, phospholipase D1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CVDD
  • Links
    NCBI Gene ID: 5337
    neXtProt AC: NX_Q13393
    UniProt: Q13393

  • Chr Location
    3q26.31; chr3:171600404-171810494 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show reduced tumor growth and angiogenesis. Homozygotes for a second null allele show abnormal hepatic autophagy after food restriction. Homozygotes for a third null allele show altered platelet activation and protection from thrombosis and ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028207 VEGA Gene Model | MGI Sequence Detail 194668 C57BL/6J ±  kb
transcript OTTMUST00000069880 VEGA | MGI Sequence Detail 3732 Not Applicable  
polypeptide OTTMUSP00000035549 VEGA | MGI Sequence Detail 1074 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1611 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 53
    cDNA 52
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-39584, MGI:2139589, MGI:2140090
References
more
  • Summaries
    All 74
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:38674 Hammond SM, et al., Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem. 1997 Feb 7;272(6):3860-8
  • Latest
    J:237995 Kang DW, et al., Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. Cancer Res. 2017 Jan 01;77(1):142-152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory