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Cxcr4
Gene Detail
Symbol

Name
ID
Cxcr4
chemokine (C-X-C motif) receptor 4
MGI:109563
Synonyms
b2b220Clo, CD184, Cmkar4, fusin, PB-CKR, Sdf1r
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:128588199-128592293 bp, - strand
From VEGA annotation of GRCm38

  4095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CXCR4
Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr4

Human
homologs
CXCR4, chemokine (C-X-C motif) receptor 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7852
neXtProt AC: NX_P61073

Human Synonyms: CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LAP-3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS

Human Chr (Location): 2q21; chr2:136114349-136118155 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CXCR4

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from APF , CvDC )
 
Homozygous targeted null mutants affect viability and body size, and result in abnormal lungs, kidneys, immune system, hematopoiesis, myelopoiesis, and anomalies in cerebellar foliation and neuronal cell layer development.
 
Human Diseases Modeled in Mice Using Cxcr4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(29)
Interactions
Cxcr4 interacts with 172 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process ameboidal-type cell migration, brain development, ...
Component cell-cell junction, cell junction, ...
Function actin binding, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (78 records)
Data Summary: Results (292)    Tissues (153)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 233
Northern blot 22
Western blot 2
RT-PCR 22
RNase protection 5
cDNA source data(59)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CXCR4 ; Xenbase cxcr4 ; ZFIN cxcr4a, cxcr4b    NEW 
Molecular
reagents
All nucleic(69) Genomic(2) cDNA(59) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020918 (Evidence)
Ensembl Gene Model ENSMUSG00000045382 (Evidence)
Entrez Gene 12767 (Evidence)
UniGene 1401
DFCI TC1578448, TC1598687, TC1647392
DoTS DT.532064
NIA Mouse Gene Index U021733
Consensus CDS Project CCDS15254.1
International Mouse Phenotyping Consortium Status Cxcr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020918 VEGA Gene Model | MGI Sequence Detail 4095 C57BL/6J ±  kb
transcript OTTMUST00000049443 VEGA | MGI Sequence Detail 1805 Not Applicable 
polypeptide OTTMUSP00000022912 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001277 CXC chemokine receptor 4
InterPro IPR022726 CXC chemokine receptor 4 N-terminal domain
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001208 C-X-C chemokine receptor type 4
References
(Earliest) J:34750 Nagasawa T, et al., Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996 Aug 15;382(6592):635-8
(Latest) J:219886 McDermott DH, et al., Chromothriptic cure of WHIM syndrome. Cell. 2015 Feb 12;160(4):686-99
All references(235)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-39562, MGI:5311025

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory