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Cxcr4
Gene Detail
 Symbol
Name
ID
Cxcr4
chemokine (C-X-C motif) receptor 4
MGI:109563
Synonyms b2b220Clo, CD184, Cmkar4, fusin, PB-CKR, Sdf1r
Feature Type protein coding gene
Genetic Map
Chromosome 1
56.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:128588199-128592293 bp, - strand
From VEGA annotation of GRCm38

  4095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr4

Human
homologs
Human Homolog CXCR4, chemokine (C-X-C motif) receptor 4
NCBI Gene ID 7852
neXtProt AC  NX_P61073
Human Synonyms  CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LAP-3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Human Chr (Location)  2q21; chr2:136114349-136118155 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CXCR4
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from APF )
 
Homozygous targeted null mutants affect viability and body size, and result in abnormal lungs, kidneys, immune system, hematopoiesis, myelopoiesis, and anomalies in cerebellar foliation and neuronal cell layer development.
 
Human Diseases Modeled Using Mouse Cxcr4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(29)
Interactions
Cxcr4 interacts with 172 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process ameboidal cell migration, brain development, ...
Component cell-cell junction, cell junction, ...
Function actin binding, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (281)    Tissues (150)    Images (52)
Theiler Stages: 11, 13, 17, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 233
Northern blot 22
Western blot 2
RT-PCR 16
RNase protection 5
cDNA source data(59)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(2) cDNA(59) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020918 (Evidence)
Ensembl Gene ModelENSMUSG00000045382 (Evidence)
Entrez Gene12767 (Evidence)
UniGene1401
DFCITC1578448, TC1598687, TC1647392
DoTSDT.532064
NIA Mouse Gene IndexU021733
Consensus CDS ProjectCCDS15254.1
International Mouse Knockout Project StatusCxcr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020918 VEGA Gene Model | MGI Sequence Detail 4095 C57BL/6J ±  kb
transcript OTTMUST00000049443 VEGA | MGI Sequence Detail 1805 Not Applicable 
polypeptide OTTMUSP00000022912 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001277 CXC chemokine receptor 4
InterPro IPR022726 CXC chemokine receptor 4 N-terminal domain
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001208 C-X-C chemokine receptor type 4
References (Earliest) J:34750 Nagasawa T, et al., Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996 Aug 15;382(6592):635-8
(Latest) J:208337 Bodea GO, et al., Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development. 2014 Feb;141(3):661-73
All references(225)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39562, MGI:5311025

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory