Cxcr4
Gene Detail

Symbol Name ID

Cxcr4 chemokine (C-X-C motif) receptor 4 MGI:109563

Synonyms

CD184, Cmkar4, fusin, PB-CKR, Sdf1r

Feature Type

protein coding gene

Genetic Map

Chromosome 1

56.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:128588199-128592293 bp, - strand From VEGA annotation of GRCm38   4095 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr4

Human homologs

Human Homolog		CXCR4, chemokine (C-X-C motif) receptor 4
NCBI Gene ID		7852
neXtProt AC		NX_P61073
Human Synonyms		CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Human Chr (Location)		2q21; chr2:136871919-136875725 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CXCR4

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygous targeted null mutants affect viability and body size, and result in abnormal lungs, kidneys, immune system, hematopoiesis, myelopoiesis, and anomalies in cerebellar foliation and neuronal cell layer development.

 
Human Diseases Modeled Using Mouse Cxcr4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	ameboidal cell migration, brain development, ...
Component	cell leading edge, cell surface, ...
Function	actin binding, chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (64 records)
Data Summary: Results (281)    Tissues (150)    Images (52)
Theiler Stages: 11, 13, 17, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	233
Northern blot	22
Western blot	2
RT-PCR	16
RNase protection	5

cDNA source data(59)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(68) Genomic(2) cDNA(59) Primer pair(6) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020918 (Evidence)
Ensembl Gene Model	ENSMUSG00000045382 (Evidence)
Entrez Gene	12767 (Evidence)
UniGene	1401
DFCI	TC1578448, TC1598687, TC1647392
DoTS	DT.532064
NIA Mouse Gene Index	U021733
Consensus CDS Project	CCDS15254.1
International Mouse Knockout Project Status	Cxcr4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020918	VEGA Gene Model | MGI Sequence Detail	4095	C57BL/6J
transcript	OTTMUST00000049443	VEGA | MGI Sequence Detail	1805	Not Applicable
polypeptide	OTTMUSP00000022912	VEGA | MGI Sequence Detail	359	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(48 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000355	Chemokine receptor
InterPro	IPR001277	CXC chemokine receptor, type 4
InterPro	IPR022726	CXC chemokine receptor, type 4, N-terminal
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001208	C-X-C chemokine receptor type 4

References

(Earliest) J:34750 Nagasawa T, et al., Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996 Aug 15;382(6592):635-8
(Latest) J:195048 Li W, et al., Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell. 2013 Feb 25;24(4):359-71
All references(202)

Other accession IDs

MGD-MRK-39562