144 phenotypes from 10 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19tm1(cre)Cgn/Cd19+ Cxcr4tm1Tng/Cxcr4tm2Tng involves: 129P2/OlaHsd * C57BL/6	decreased plasma cell number	J:109147
Cxcr4b2b220Clo/Cxcr4b2b220Clo C57BL/6J-Cxcr4b2b220Clo	aorta stenosis	J:175213
	aortic arch hypoplasia	J:175213
	aortic valve atresia	J:175213
	double aortic arch	J:175213
	duplex kidney	J:175213
	hydronephrosis	J:175213
	muscular ventricular septal defect	J:175213
	perimembraneous ventricular septal defect	J:175213
	polycystic kidney	J:175213
	right aortic arch	J:175213
Cxcr4em1(IMPC)Mbp/Cxcr4+ C57BL/6NCrl-Cxcr4em1(IMPC)Mbp/MbpMmucd	abnormal eyelid morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta size	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	decreased circulating creatinine level	J:211773
	embryonic growth retardation	J:211773
	enlarged kidney	J:211773
	enlarged spleen	J:211773
	enlarged testis	J:211773
	increased leukocyte cell number	J:211773
	increased lymphocyte cell number	J:211773
	increased monocyte cell number	J:211773
	microphthalmia	J:211773
	persistence of hyaloid vascular system	J:211773
Cxcr4em1(IMPC)Mbp/Cxcr4em1(IMPC)Mbp C57BL/6NCrl-Cxcr4em1(IMPC)Mbp/MbpMmucd	abnormal blood vessel morphology	J:211773
	abnormal limb morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta size	J:211773
	edema	J:211773
	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773
Cxcr4tm1.1Bala/Cxcr4+ B6.129S2-Cxcr4tm1.1Bala	abnormal CD4-positive, alpha-beta T cell number	J:186735
	abnormal cell chemotaxis	J:186735
	abnormal immune system cell morphology	J:186735
	abnormal immune system morphology	J:186735
	abnormal immune system organ morphology	J:186735
	abnormal immune system physiology	J:186735
	abnormal lymph node B cell domain morphology	J:186735
	abnormal lymph node morphology	J:186735
	abnormal neutrophil morphology	J:186735
	abnormal NK cell physiology	J:178789
	abnormal spleen morphology	J:186735
	abnormal spleen white pulp morphology	J:186735
	abnormal thymus morphology	J:186735
	decreased B cell apoptosis	J:186735
	decreased B cell number	J:186735
	decreased immature B cell number	J:186735
	decreased leukocyte cell number	J:186735
	decreased NK cell number	J:178789
	decreased spleen weight	J:186735
	decreased T cell number	J:186735
	increased IgG level	J:186735
	increased IgM level	J:186735
	increased immunoglobulin level	J:186735
	increased mature B cell number	J:186735
	increased NK cell number	J:178789
Cxcr4tm1Qma/Cxcr4tm1Qma B6.129X-Cxcr4tm1Qma/J	abnormal muscle precursor cell migration	J:100909
	abnormal myogenesis	J:100909
Cxcr4tm1Qma/Cxcr4tm1Qma involves: 129X1/SvJ	abnormal cerebellum morphology	J:49070
	absent cerebellar foliation	J:49070
	atelectasis	J:49070
	decreased body size	J:49070
	decreased bone marrow cell number	J:49070
	decreased pro-B cell number	J:49070
	ectopic Purkinje cell	J:49070
	impaired myelopoiesis	J:49070
	kidney hemorrhage	J:49070
	kidney vascular congestion	J:49070
	perinatal lethality, incomplete penetrance	J:49070
	thin external granule cell layer	J:49070
Cxcr4tm1Qma/Cxcr4tm1Qma involves: 129X1/SvJ * C57BL/6	abnormal nervous system physiology	J:132342
	decreased susceptibility to Retroviridae infection	J:132342
	increased susceptibility to Retroviridae infection induced morbidity/mortality	J:132342
Cxcr4tm1Tng/Cxcr4tm1Tng B6.Cg-Cxcr4tm1Tng	abnormal primordial germ cell migration	J:83291
	abnormal T cell differentiation	J:82996
	decreased double-positive T cell number	J:82996
Cxcr4tm1Tng/Cxcr4tm1Tng involves: 129P2/OlaHsd	abnormal angiogenesis	J:69256
	abnormal B cell differentiation	J:69256
	abnormal developmental vascular remodeling	J:195048
	abnormal heart morphology	J:178190
	abnormal heart right ventricle outflow tract morphology	J:178190
	abnormal skin vasculature morphology	J:195048
	abnormal vascular smooth muscle morphology	J:195048
	abnormal vasculogenesis	J:178190
	normal cardiovascular system phenotype	J:69256
	normal digestive/alimentary phenotype	J:69256
	normal embryo phenotype	J:69256
	failure of myelopoiesis	J:69256
	neonatal lethality, complete penetrance	J:69256
	normal nervous system phenotype	J:195048
	perimembraneous ventricular septal defect	J:69256
	perinatal lethality, incomplete penetrance	J:69256
	poor arterial differentiation	J:195048
	small intestine hemorrhage	J:69256
	thick mitral valve cusps	J:178190
	ventricular septal defect	J:178190
Cxcr4tm1Tng/Cxcr4tm2Tng Tg(Tek-cre)12Flv/0 involves: 129P2/OlaHsd * C3H * C57BL/6	abnormal developmental vascular remodeling	J:195048
	abnormal skin vasculature morphology	J:195048
	abnormal vascular smooth muscle morphology	J:195048
	normal nervous system phenotype	J:195048
	poor arterial differentiation	J:195048
Cxcr4tm1Yiw/Cxcr4tm1Yiw Tg(Lck-cre)1Jtak/0 involves: 129P2/OlaHsd	abnormal leukocyte migration	J:164872
	decreased susceptibility to induced arthritis	J:164872
	decreased thymocyte number	J:164872
Cxcr4tm1Yzo/Cxcr4tm1Yzo Not Specified	abnormal B cell differentiation	J:167314
	abnormal B cell physiology	J:167314
	abnormal cerebellum external granule cell layer morphology	J:69255
	abnormal cerebellum morphology	J:69255
	abnormal cerebral cortex morphology	J:81783
	abnormal dentate gyrus morphology	J:79852, J:81783
	abnormal interventricular septum morphology	J:69255
	abnormal leukopoiesis	J:69255
	abnormal lymphopoiesis	J:69255
	abnormal primordial germ cell migration	J:84597
	decreased fetal size	J:69255
	decreased primordial germ cell number	J:84597
	hydrops fetalis	J:69255
	impaired myelopoiesis	J:69255
	lethality throughout fetal growth and development, incomplete penetrance	J:69255
	normal nervous system phenotype	J:81783
	perinatal lethality, complete penetrance	J:167314
Cxcr4tm2Yzo/Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+ involves: 129P2/OlaHsd	abnormal B cell differentiation	J:94911
	abnormal Peyer's patch follicle morphology	J:94911
	decreased B-1 B cell number	J:94911
	decreased B-2 B cell number	J:94911
	decreased immunoglobulin level	J:94911
	decreased mature B cell number	J:94911
	decreased plasma cell number	J:94911
Cxcr4tm2Yzo/Cxcr4tm2Yzo Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6	normal adipose tissue phenotype	J:217569
	normal growth/size/body region phenotype	J:217569
	increased lymphocyte cell number	J:217569
	increased monocyte cell number	J:217569
	increased neutrophil cell number	J:217569
Cxcr4tm2Yzo/Cxcr4tm2Yzo Tg(Fabp4-cre)1Rev/0 involves: 129P2/OlaHsd * C57BL/6	abnormal macrophage cell number	J:217569
	decreased B cell number	J:217569
	decreased CD4-positive, alpha-beta T cell number	J:217569
	decreased oxygen consumption	J:217569
	normal growth/size/body region phenotype	J:217569
	normal homeostasis/metabolism phenotype	J:217569
	impaired adaptive thermogenesis	J:217569
	increased brown adipose tissue mass	J:217569
	increased brown fat cell size	J:217569
	increased CD8-positive, alpha-beta T cell number	J:217569
	increased gonadal fat pad weight	J:217569
	increased mesenteric fat pad weight	J:217569
	increased retroperitoneal fat pad weight	J:217569
	increased subcutaneous adipose tissue amount	J:217569
	increased susceptibility to diet-induced obesity	J:217569
	increased total body fat amount	J:217569
	increased white adipose tissue mass	J:217569
	increased white fat cell size	J:217569
Cxcr4tm2Yzo/Cxcr4tm2Yzo Tg(Myh6-cre)2182Mds/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal heart morphology	J:289614
	abnormal myocardial fiber morphology	J:289614
	cardiac hypertrophy	J:289614
	cardiac interstitial fibrosis	J:289614
	cardiomyopathy	J:289614
	congestive heart failure	J:289614
	decreased left ventricle systolic pressure	J:289614
	decreased ventricle muscle contractility	J:289614
	increased heart weight	J:289614
	increased physiological sensitivity to xenobiotic	J:289614
	perivascular fibrosis	J:289614
	premature death	J:289614
Cxcr4tm2Yzo/Cxcr4tm3.1Yzo Cd19tm1(cre)Cgn/Cd19+ involves: 129P2/OlaHsd	abnormal B cell differentiation	J:167314
Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo Not Specified	abnormal B cell physiology	J:167314
	abnormal blood vessel morphology	J:167314
	abnormal cerebellum external granule cell layer morphology	J:167314
	decreased pro-B cell number	J:167314
	impaired myelopoiesis	J:167314
	perinatal lethality, complete penetrance	J:167314