Symbol
Name
ID

Cxcr4
C-X-C motif chemokine receptor 4
MGI:109563

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgG level

Monoclonal immunoglobulin M proteinemia

Polyclonal elevation of IgM

Decreased circulating antibody level

Periorbital edema

Pedal edema

Abnormal circulating lactate dehydrogenase concentration

Increased circulating lactate dehydrogenase concentration

Elevated circulating alkaline phosphatase concentration

Elevated erythrocyte sedimentation rate

Joint swelling

Pleural effusion

Fever

Increased level of L-fucose in urine

Disease(s) Associated with CXCR4

lymphoplasmacytic lymphoma

osteosarcoma

stomach cancer

WHIM syndrome

Mouse Phenotypes		homeostasis/metabolism phenotype	increased susceptibility to diet-induced obesity	impaired adaptive thermogenesis	decreased circulating creatinine level	edema	hydrops fetalis	decreased oxygen consumption	increased physiological sensitivity to xenobiotic
Availability	Mouse Genotype	homeostasis/metabolism phenotype	increased susceptibility to diet-induced obesity	impaired adaptive thermogenesis	decreased circulating creatinine level	edema	hydrops fetalis	decreased oxygen consumption	increased physiological sensitivity to xenobiotic
	Cxcr4^em1(IMPC)Mbp/Cxcr4^em1(IMPC)Mbp
	Cxcr4^tm1Yzo/Cxcr4^tm1Yzo
	Cxcr4^em1(IMPC)Mbp/Cxcr4⁺
	Cxcr4^tm2Yzo/Cxcr4^tm2Yzo Tg(Fabp4-cre)1Rev/0 (conditional)	*
	Cxcr4^tm2Yzo/Cxcr4^tm2Yzo Tg(Myh6-cre)2182Mds/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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