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Ctsc
Gene Detail
Symbol

Name
ID
Ctsc
cathepsin C
MGI:109553
Synonyms
dipeptidylpeptidase 1, DPP1, DPPI
Feature Type
protein coding gene
Genetic Map
Chromosome 7
49.11 cM, cytoband D3-E1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:88278085-88310888 bp, + strand
From VEGA annotation of GRCm38

  32804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTSC
Gene Tree: Ctsc

Human
homologs
CTSC, cathepsin C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1075
neXtProt AC: NX_P53634

Human Synonyms: CPPI, DPP1, DPPI, DPP-I, HMS, JP, JPD, PALS, PDON1, PLS

Human Chr (Location): 11q14.2; chr11:88293592-88337773 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CTSC

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for some targeted null mutations exhibit cytotoxic lymphocytes with inactive granzymes A and B which are incapable of granule-mediated apoptosis. Mutant mast cells lack activated chymase activity. Homozygotes for other alleles display a scruffy coat with age and behavioral abnormalities
 
Human Diseases Modeled in Mice Using Ctsc (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ctsc interacts with 194 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (147)    Tissues (80)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 67
RT-PCR 38
cDNA source data(276)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CTSC ; Xenbase ctsc    NEW 
Molecular
reagents
All nucleic(279) Genomic(2) cDNA(276) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031137 (Evidence)
Ensembl Gene Model ENSMUSG00000030560 (Evidence)
Entrez Gene 13032 (Evidence)
UniGene 322945
DFCI TC1693417, TC1573181
DoTS DT.103569591, DT.494458, DT.99582347
NIA Mouse Gene Index U008349
EC 3.4.14.1
Consensus CDS Project CCDS21438.1
International Mouse Phenotyping Consortium Status Ctsc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031137 VEGA Gene Model | MGI Sequence Detail 32804 C57BL/6J ±  kb
transcript OTTMUST00000077133 VEGA | MGI Sequence Detail 2493 Not Applicable 
polypeptide OTTMUSP00000040719 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(11)
Polymorphisms
SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014882 Cathepsin C exclusion
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
Protein Ontology PR:000006024 dipeptidyl peptidase 1
References
(Earliest) J:47503 Paris A, et al., Molecular cloning and sequence analysis of human preprocathepsin C. FEBS Lett. 1995 Aug 7;369(2-3):326-30
(Latest) J:202911 Deu E, et al., Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18244-9
All references(60)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39552, MGI:2141863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory