Ctsc
Gene Detail

Symbol Name ID

Ctsc cathepsin C MGI:109553

Synonyms

dipeptidylpeptidase 1, DPP1, DPPI

Feature Type

protein coding gene

Genetic Map

Chromosome 7

49.11 cM, cytoband D3-E1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:88278085-88310888 bp, + strand From VEGA annotation of GRCm38   32804 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ctsc ± 2 cM)

Gene Tree: Ctsc

Human ortholog

CTSC cathepsin C NCBI Gene ID 1075
Human Synonyms: CPPI, DPP1, DPPI, DPP-I, HMS, JP, JPD, PALS, PDON1, PLS
Human Chr11:88026760-88070941 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CTSC (3)

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygotes for some targeted null mutations exhibit cytotoxic lymphocytes with inactive granzymes A and B which are incapable of granule-mediated apoptosis. Mutant mast cells lack activated chymase activity. Homozygotes for other alleles display a scruffy coat with age and behavioral abnormalities

 
Human Diseases Modeled Using Mouse Ctsc (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	proteolysis, response to organic substance, ...
Component	endoplasmic reticulum, Golgi apparatus, ...
Function	chloride ion binding, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (147)    Tissues (80)    Images (38)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42
In situ reporter (knock in)	67
RT-PCR	38

cDNA source data(276)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(279) Genomic(2) cDNA(276) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031137 (Evidence)
Ensembl Gene Model	ENSMUSG00000030560 (Evidence)
Entrez Gene	13032 (Evidence)
UniGene	322945
DFCI	TC1573181
DoTS	DT.103569591, DT.494458
NIA Mouse Gene Index	U008349
EC	3.4.14.1
Consensus CDS Project	CCDS21438.1
International Mouse Knockout Project Status	Ctsc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031137	VEGA Gene Model | MGI Sequence Detail	32804	C57BL/6J
transcript	OTTMUST00000077133	VEGA | MGI Sequence Detail	2493	Not Applicable
polypeptide	OTTMUSP00000040719	VEGA | MGI Sequence Detail	462	Not Applicable

All sequences(60) RefSeq(2) UniProt(11)

Polymorphisms

SNPs(243 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014882	Cathepsin C exclusion
InterPro	IPR025661	Cysteine peptidase, asparagine active site
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR025660	Cysteine peptidase, histidine active site
InterPro	IPR013128	Peptidase C1A, papain
InterPro	IPR000668	Peptidase C1A, papain C-terminal
Protein Ontology	PR:000006024	dipeptidyl peptidase 1

References

(Earliest) J:47503 Paris A, et al., Molecular cloning and sequence analysis of human preprocathepsin C. FEBS Lett. 1995 Aug 7;369(2-3):326-30
(Latest) J:190231 Kono H, et al., The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C. J Immunol. 2012 Oct 1;189(7):3734-40
All references(57)

Other accession IDs

MGD-MRK-39552, MGI:2141863