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Phenotypes Associated with This Genotype
Genotype
MGI:3606731
Allelic
Composition		 Ctsctm1Dgen/Ctsctm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsctm1Dgen mutation (1 available); any Ctsc mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased prepulse inhibition ( J:101679 )
• significantly decreased prepulse inhibition during startle testing

behavior/neurological
increased thermal nociceptive threshold ( J:101679 )
• increased thermal response latency during tail flick testing

integument
disheveled coat ( J:101679 )
• scruffy appearance of coat at 300 days of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
 J:101679

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory