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Cfc1
Gene Detail
Symbol

Name
ID
Cfc1
cripto, FRL-1, cryptic family 1
MGI:109448
Synonyms
b2b970Clo, cryptic
Feature Type
protein coding gene
Genetic Map
Chromosome 1
13.34 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:34535648-34544311 bp, + strand
From VEGA annotation of GRCm38

  8664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:50007  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken

Gene Tree: Cfc1

Human
homologs
Human Homolog CFC1, cripto, FRL-1, cryptic family 1
NCBI Gene ID 55997
neXtProt AC  NX_P0CG37
Human Synonyms  CFC1B, CRYPTIC, DTGA2, HTX2
Human Chr (Location)  2q21.1; chr2:130592165-130599575 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CFC1
Human Homolog CFC1B, cripto, FRL-1, cryptic family 1B
NCBI Gene ID 653275
neXtProt AC  NX_P0CG36
Human Chr (Location)  2q21.1; chr2:130521094-130527992 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(2) Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted null mutations of this gene result in left-right laterality defects, including randomization of abdominal situs, asplenia or severe hyposplenia, pulmonary right isomerism, randomized embryo turning and cardiac looping, and postnatal death due to complex cardiac malformations.
 
Human Diseases Modeled Using Mouse Cfc1 (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(41)
Interactions
Cfc1 interacts with 22 markers (Mir125b-2, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (86)    Tissues (27)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
RT-PCR 36
RNase protection 12
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000049475 (Evidence)
Ensembl Gene ModelENSMUSG00000026124 (Evidence)
Entrez Gene12627 (Evidence)
Consensus CDS ProjectCCDS14869.1
International Mouse Knockout Project StatusCfc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049475 VEGA Gene Model | MGI Sequence Detail 8664 C57BL/6J ±  kb
transcript OTTMUST00000126125 VEGA | MGI Sequence Detail 1038 Not Applicable 
polypeptide OTTMUSP00000068257 VEGA | MGI Sequence Detail 202 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)    SNPs within 2kb including multiple locations(138)
Protein-related
information
ResourceIDDescription
InterPro IPR019011 Cryptic/Cripto, CFC domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000005375 cryptic protein
References
(Earliest) J:38387 Shen MM, et al., A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development. 1997 Jan;124(2):429-42
(Latest) J:198687 Nowotschin S, et al., The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013 May 1;27(9):997-1002
All references(54)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-38493, MGI:2138529, MGI:5311344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory