Cfc1
Gene Detail

Symbol Name ID

Cfc1 cripto, FRL-1, cryptic family 1 MGI:109448

Synonyms

b2b970Clo, cryptic

Feature Type

protein coding gene

Genetic Map

Chromosome 1

13.34 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:34535648-34544311 bp, + strand From NCBI annotation of GRCm38   8664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:50007  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken

Gene Tree: Cfc1

Human homologs

Human Homolog		CFC1, cripto, FRL-1, cryptic family 1
NCBI Gene ID		55997
neXtProt AC		NX_P0CG37
Human Synonyms		CFC1B, CRYPTIC, DTGA2, HTX2
Human Chr (Location)		2q21.1; chr2:131349738-131357148 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CFC1
Human Homolog		CFC1B, cripto, FRL-1, cryptic family 1B
NCBI Gene ID		653275
neXtProt AC		NX_P0CG36
Human Chr (Location)		2q21.1; chr2:131278667-131285565 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(5) Chemically induced(1)
 

Targeted null mutations of this gene result in left-right laterality defects, including randomization of abdominal situs, asplenia or severe hyposplenia, pulmonary right isomerism, randomized embryo turning and cardiac looping, and postnatal death due to complex cardiac malformations.

 
Human Diseases Modeled Using Mouse Cfc1 (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(15)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	anatomical structure development, anterior/posterior pattern specification, ...
Component	anchored to membrane, extracellular region, ...
Function	activin receptor binding, nodal binding

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (86)    Tissues (27)    Images (26)
Theiler Stages: 2, 3, 9, 10, 11, 12, 13, 15, 17, 19, 28

Assay Type	Results
RNA in situ	38
RT-PCR	36
RNase protection	12

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(9) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026124 (Evidence)
Entrez Gene	12627 (Evidence)
Consensus CDS Project	CCDS14869.1
International Mouse Knockout Project Status	Cfc1

Sequences

Length	Strain/Species
genomic	12627	NCBI Gene Model | MGI Sequence Detail	8664	C57BL/6J
transcript	NM_007685	RefSeq | MGI Sequence Detail	1038	129/Sv
polypeptide	P97766	UniProt | EBI | MGI Sequence Detail	202	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019011	Cryptic/Cripto, CFC domain
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
Protein Ontology	PR:000005375	cryptic protein

Graphical View of Protein Domain Structure

References

(Earliest) J:38387 Shen MM, et al., A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development. 1997 Jan;124(2):429-42
(Latest) J:189072 Spiller CM, et al., Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. Development. 2012 Nov;139(22):4123-32
All references(52)

Other accession IDs

MGD-MRK-38493, MGI:2138529, MGI:5311344